Why can Sophora japonica charcoal enhance the hemostatic effect?

Stir-frying charcoal is a common processing method of traditional Chinese medicine, and charcoal medicine is also widely used in traditional Chinese medicine clinic. Modern classification is mainly based on the material basis of carbon drugs to stop bleeding. It is considered that the hemostatic effect of traditional Chinese medicine charcoal frying is complex, which is a comprehensive effect of multi-components, multi-links and multi-targets. After charcoal frying, it enhances or produces hemostatic effect. According to the hemostatic components of charcoal medicine, the author discussed the problem of "components to enhance hemostasis after frying charcoal" again, and the report is as follows.

Research status of 1

Study on 1. 1 hemostatic components

1。 1。 Effect of 1 charcoal on hemostasis After high temperature carbonization, Chinese herbal pieces produce a lot of charcoal, which makes the whole charcoal loose and porous, so it has astringent taste. In addition, activated carbon itself has astringency and shows hemostatic effect. Such as raw charcoal and lotus charcoal [1 ~ 3]. This is the unified understanding of Chinese medicine charcoal medicine hemostasis at present.

1。 1。 2 The effect of tannin on hemostasis Tannin is a complex polyphenol compound which is widely distributed in medicinal plants. It can combine with protein to form water-insoluble macromolecular compounds, so it has astringency, can protect the mucosal surface, prevent excessive secretion and inhibit excessive bleeding [4]. For example, after carbonization, the tannin content of Sanguisorba officinalis and Sophora japonica can be increased, and its hemostatic and antidiarrheal effects are also strengthened accordingly [5].

1。 1。 Effect of 3Ca2+ and trace elements on hemostasis Ca2+ belongs to a human coagulation factor. Calcium in plants forms soluble Ca2+ after oral administration, which is involved in blood coagulation. For example, the content of Ca2+ in palm charcoal increased obviously after frying [6]. In addition, trace elements such as zinc, manganese, copper, iron and calcium in some traditional Chinese medicines such as Platycladus orientalis leaves and hawthorn have changed after carbonization, and the hemostatic effect has been enhanced compared with that of raw products [4,7].

1。 According to the location of bleeding, bleeding syndrome can be divided into internal bleeding and external bleeding. Because most Chinese medicines are decocted, they are mainly used to treat internal bleeding syndrome, such as gastrointestinal bleeding and pulmonary tuberculosis hemoptysis, and their hemostasis is multi-component (such as carbon, tannin, Ca2+ and trace elements), multi-link and multi-target. For the treatment of external bleeding syndrome, single Chinese medicine, such as Gan [8], is often used, which mainly has the function of oppressive mechanical hemostasis.