2 Pharmacopoeia Standard of Xiaochaihu Granules 2. 1 Name Xiaochaihu Granules
Xiaochaihu granules
2.2 Prescription Bupleurum 150g, Scutellaria baicalensis Georgi 56g, Jiang Banxia 56g, Codonopsis pilosula 56g, Ginger 56g, Glycyrrhiza uralensis Fisch 56g and Jujube 56g.
2.3 Boil Bupleurum, Scutellaria baicalensis Georgi, Codonopsis pilosula, Glycyrrhiza uralensis Fisch and Jujube in water twice, each time for 65438 0.5 hours, combine decoctions, filter, and concentrate the filtrate to an appropriate amount. Jiang Banxia and ginger were soaked in 70% ethanol for 24 hours, then percolated, and about 600ml of percolate was collected. Recovering ethanol, mixing with the above concentrated solution, concentrating to an appropriate amount, adding appropriate amount of sucrose, granulating, and drying to obtain1000g; Or mixing with proper amount of dextrin, mannitol and other auxiliary materials to make 400g granules; ; Or mixed with proper amount of lactose, and made into 250g granules.
2.4 Characteristics This product is yellow to brown granules; It tastes sweet. Or brownish yellow particles; Light and slightly spicy [specifications (2) and (3)].
2.5 Identification (1) Take 6g[ specification (1)], 2.5g[ specification (2)] or 1.5g[ specification (3)] of this product, crush it, add 20ml of ethanol, ultrasonic for 20min, filter, evaporate the filtrate, and add 20ml of water to dissolve the residue. Take an appropriate amount of baicalin reference substance and add methanol to make a solution containing 1ml as reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia Part I, 20 10), each of the above two solutions 10μl was adsorbed on the same silica gel G thin-layer plate, and the sodium carboxymethyl cellulose solution containing 4% sodium acetate was used as the adhesive. In the test sample chromatography, in ethyl acetate-butanone-formic acid-water (5: 3:/kloc)
(2) Take 65,438+0g of Glycyrrhiza uralensis Fisch, add appropriate amount of water, decoct for 30min, cool, filter, concentrate the filtrate to 20ml, shake and extract with water-saturated n-butanol twice, 20ml each time, combine the n-butanol extractive solutions, wash with n-butanol saturated water twice, 65,438+00ml each time, evaporate the n-butanol solution, and add 65438±0ml methanol to dissolve the residue. According to thin-layer chromatography (Pharmacopoeia 20 10, Appendix ⅵ b). [Identification ]( 1) test solution 10μl and the above-mentioned reference medicinal solution 5 ~ 10μ l were respectively absorbed on the same silica gel G thin-layer plate, and chloroform-methanol-water (40:11) was used as the developing agent. In the chromatogram of the test sample, the spots with the same color appear at the positions corresponding to the chromatogram of the control medicinal materials.
(3) Take 6g[ specification (1)], 2.5g[ specification (2)] or 1.5g[ specification (3)] of this product, add 20ml of water, stir and dissolve, centrifuge, take the supernatant, and add it to polyamide column (100 ~ 2000). In addition, DC Bupleurum 65438±0g g. Add a proper amount of water, decoct for 65438±0.5h, filter, concentrate the filtrate to about 65438±00ml, and put it on a polyamide column (100 ~ 200 mesh, 4g, 2cm in inner diameter, filled by wet method), with water consumption of 65438 000 ml and 50% respectively. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia Part I, 20 10), 2 ~ 10 μ l of test solution and 2μl of control medicinal solution were absorbed on the same silica gel G thin-layer plate, and ethyl acetate-ethanol-water (12: 2: 1) was used as the developing agent. In the chromatogram of the test sample, fluorescent spots with the same color appear at the positions corresponding to the chromatogram of the control medicinal materials.
2.6 The inspection shall comply with the relevant provisions of Granules (Appendix I C of Pharmacopoeia 20 10).
2.7 the content was determined by high performance liquid chromatography (appendix ⅵ D of pharmacopoeia I, 20 10).
2.7. 1 chromatographic conditions and system applicability test, using octadecylsilane bonded silica gel as filler; Using methanol-water-phosphoric acid (47∶53∶0.2) as mobile phase; The detection wavelength is 3 15 nm. The theoretical plate number should be not less than 3000 calculated by baicalin peak.
2.7.2 Preparation of reference substance solution Take a proper amount of baicalin reference substance, weigh it accurately, and add 70% ethanol to make a solution containing 60μg per 1ml.
2.7.3 Preparation of test solution Take different volumes of this product, mix well, take appropriate amount, grind, take about 3g[ specification (1)], 1.3g[ specification (2)] or about 0.8g[ specification (3)], weigh it accurately, and put it in a conical flask with a stopper.
2.7.4 Determination method Accurately absorb 65,438+00μ l of control solution and test solution respectively, inject them into liquid chromatograph, and determine to obtain the product.
Each bag of this product contains baicalin (C 21h18o11), not less than 20.0mg.
2.8 Indications: relieving exterior syndrome, dissipating heat, soothing liver and regulating stomach. Can be used for exogenous shaoyang syndrome, characterized by cold and heat, fullness in chest and hypochondrium, loss of appetite, vexation and vomiting, bitter taste in mouth and dry throat.
2.9 Usage and dosage: Take it with boiled water. 1 ~ 2 bag once, three times a day.
2. 10 specification (1) 10g per bag.
(2) 4g per bag (excluding sucrose)
(3) 2.5g per bag (excluding sucrose)
2. 1 1 storage seal.
2. 12 Edition People's Republic of China (PRC) Pharmacopoeia 20 10 Edition
3. Instructions for Xiaochaihu Granules 3. 1 drug type Chinese traditional medicine
3.2 Drug Name Xiaochaihu Granules
3.3 Chinese Pinyin of Medicines 3.4 English Name of Medicines 3.5 Components 3.6 Traits 3.7 Action Category 3.8 Indications/Functions Indications for relieving exterior syndrome, clearing away heat, soothing the liver and regulating the stomach. Can be used for exogenous shaoyang syndrome, characterized by cold and heat, fullness in chest and hypochondrium, loss of appetite, vexation and vomiting, bitter taste in mouth and dry throat.
3.9 specifications 10g per bag
3. 10 Xiaochaihu Granules Usage: Take it with boiling water. 1 ~ 2 bag once, three times a day.
3. 1 1 contraindications 3. 12 Adverse reactions 3. 13 Precautions 1. Avoid smoking, alcohol and spicy, cold and greasy food.
2. It is not advisable to take nourishing Chinese medicine at the same time during medication.
3. Not suitable for people with colds and colds.
4. Diabetic patients and those suffering from serious chronic diseases such as hypertension, heart disease, liver disease and kidney disease should be taken under the guidance of a doctor.
Children, pregnant women, lactating women and the elderly and infirm should take it under the guidance of a doctor.
6. Patients with fever over 38.5℃ should go to the hospital.
7. If the symptoms are not relieved after taking the medicine for 3 days, you should go to the hospital.
8. It is forbidden for those who are allergic to this product, and should be used with caution for those who are allergic.
9. It is forbidden to use this product when its characteristics change.
10. Children must use it under the supervision of adults.
1 1. Please keep this product out of the reach of children.
12. If you are using other drugs, please consult a doctor or pharmacist before using this product.
3. 14 drug interaction If used with other drugs, drug interaction may occur. Please consult a doctor or pharmacist for details.
3. 15 Pharmacological Effects of Xiaochaihu Granules 3. 16 Remarks: Please read the instructions carefully and use them according to the instructions or purchase them under the guidance of pharmacists.
Xiaochaihu Granule in the ancient book Measles Prescription: Decoction for Cooling Blood and Detoxifying Toxin by Form. A hemp turns purple to red, and the internal heat is extremely hot, but it can moisturize and the particles are sharp. It is necessary to quickly cool down and detoxify, but also to resolve phlegm and relieve asthma, in order to cure the disease. ...
Continued Medical Records: [Volume 27] Treating Wind-heat, Xiong Ji Powder, and Pueraria Decoction. A pimple appears as brocade, with occasional granules, reddish in color, hot and annoying, dry tongue coating, constipation, and this rash at the same time regulates the stomach. ...
Complete Collection of Choosing Doctors: [Volume 31: Acne Rash Department (I)] Give a palm if you break the gold. Form and syndrome determine its density, and position determines its existence. If acne spreads, the granules and their sparseness are fixed; Like a pile of hemp, it's fuzzy and the density can hurt. Close to the cheek ...
"Continued Medical Records": [Volume 26: Acne Syndrome] reported acne and induction pills, once taken, diarrhea in two lines, still strong and hot. Another doctor said typhoid fever, together with Xiaochaihu decoction and Fructus Aurantii, was neither too hot nor too hot, and my mouth was dry. Yu Yue: I was strong from the beginning. ...
Continued medical record: [Volume 16] Phlegm