Contents 1 Pinyin 2 English Reference 3 Overview 4 "Six Books on Febrile Diseases: Killing Car Hammer Method" Volume Three of Zaizao Powder 4.1 Prescription 4.2 Function and Indications 4.3 Usage and Dosage of Zaizao Powder 4.4 Application 4.5 Prescription 4.6 Application 4.7 Modern indications 4.7.1 Colds 4.7.2 Rheumatoid arthritis 4.8 Pharmacological effects of Zaizao Powder 4.8.1 Effects on immune function 4.8.2 Anti-aging, antioxidant, and anti-hypoxia effects 4.8.3 Effects on the heart, circulation, and blood Rheological effect 4.8.4 Anti-pathogenic microorganism effect 4.8.5 Anti-inflammatory and analgesic effect 4.8.6 Antipyretic effect 4.8.7 Effect on nerve and endocrine function 4.8.8 Effect on digestive system function 4.9 Song 4.10 Source 5 "Surgery Dacheng" Volume Sifang Zaizao Powder 5.1 Composition 5.2 Preparation method 5.3 Function and indication 5.4 Usage and dosage of Zaizao Powder 6 References attached: 1 Zaizao Powder in ancient books* Zaizao Powder drug instructions 1 Pinyin
zài zào sǎn 2 English reference
zaizao powder [Traditional Chinese Medicine Terminology Approval Committee. Traditional Chinese Medicine Terminology (2004)]
zaizao san [Traditional Chinese Medicine Terminology Approval Committee. Traditional Chinese Medicine Terminology (2004)] )] 3 Overview
Zaizao San is the name of a prescription, and there are about two prescriptions with the same name. Among them, the "Six Books on Febrile Diseases" method of killing cart hammer is a commonly used prescription, which consists of astragalus, ginseng, cassia twig, licorice, cooked aconite, asarum, Qianghuo, saposhnikovia, Chuanxiong, and simmered ginger [1]. It has the effect of supporting yang, replenishing qi and relieving the external symptoms [2]. It is mainly used to treat patients with Yang deficiency and weak Qi, headache, fever, strong nape and spine, aversion to cold and no sweating, and no sweating after two or three doses of diaphoretic medicine [2]. 4 Zaizao Powder of Three Prescriptions in the "Six Books on Febrile Diseases: Killing the Car Chui Method"
It can be seen from the various functions of this prescription that in the treatment of colds and rheumatoid arthritis in the elderly, traditional Chinese medicine, in addition to the application of antibiotics, In addition to virus and anti-infection treatment as well as anti-inflammatory, antipyretic and other symptomatic treatments, special attention is paid to the quality and characteristics of the elderly, noting the promotion and regulation of their own immune function, and the improvement of heart, circulation and blood rheology functions. The enhancement of anti-aging and anti-oxidative damage resistance to hypoxia, and more importantly, the strengthening of the autoregulatory effect of the nervous and endocrine systems and the promotion of gastrointestinal function, which fundamentally enables the elderly to recover quickly from diseases [3 ]. This is obviously more scientific and advanced than modern medicine’s simple anti-infection, anti-inflammatory, antipyretic and other treatment methods [3].
4.1 Prescription
Astragalus, ginseng, cassia twig, licorice, cooked aconite, asarum, Qianghuo, saposhnikovia, Chuanxiong, and simmered ginger [2].
Astragalus 12g, ginseng 3g, cooked aconite 6g, Ligusticum chuanxiong 6g, saposhnikovia 6g, cassia twig 10g, peony 10g, Qiang Huo 6g, simmered ginger 6g, asarum 3g, licorice 3g, 3 jujubes [4 ]
Astragalus 6g, ginseng 3g, cassia twig 3g, licorice 1.5g, cooked aconite 3g, asarum 2g, qianghuo 3g, fang 3g, chuanxiong 3g, simmered ginger 3g, 1 pinch of jujube peony, 2 jujubes pieces[5].
Astragalus, ginseng, cassia twig, licorice, cooked aconite, asarum, Qianghuo, saposhnikovia, Chuanxiong, simmered ginger [1]. 4.2 Functions and Indications
The functions of Zai Zao Powder in three volumes of "Six Books on Febrile Diseases·Shacha Chui Fa" can help yang, replenish qi and relieve the symptoms [2]. It is mainly used to treat patients with Yang deficiency and weak Qi, headache, fever, strong nape and spine, aversion to cold and no sweating, and no sweating after two or three doses of diaphoretic medicine [2].
The Zaizao Powder from the three volumes of "Six Books on Febrile Diseases·Shacha Chui Fa" has the effect of boosting yang and replenishing qi, relieving external symptoms and dispersing cold [4]. It mainly treats symptoms of weak Yang Qi and feeling of wind and cold [4]. Symptoms include aversion to cold and fever, severe cold and mild heat, headache and strong neck, cold limbs without sweating, fatigue and lethargy, pale complexion, muffled speech, pale tongue with white coating, weak and weak pulse, or floating and weak pulse [4]. 4.3 Usage and Dosage of Zaizao Powder
Add two jujubes, boil in water and reduce to half, add a pinch of fried peony using the hammer method, boil for three times and take it warmly [2].
Add 400 ml of medicinal water, add 2 jujubes, fry until 200 ml, and drink warmly.
Put two cups of water, add two jujubes, and fry until one cup[1]. Mallet method, add a pinch of fried white peony root, fry for three times and boil, take it warmly [1] 4.4 Application
If the heat is very hot in summer, add skullcap and gypsum. 4.5 Prescriptions
The clinical manifestations of Zai Zao Powder Syndrome include body heat, aversion to cold, no sweating and headache. This is caused by exogenous wind and cold, and the evil is located on the surface of the skin [5]. Mild heat and severe cold, cold limbs and a tendency to lie down, tiredness and laziness, and a pale complexion are signs of yang deficiency in the body and exposure to wind and cold. The Yang Qi is weakened, so the pulse is thin and weak [5].
If a large dose of pungent warmth is used to dispel cold, not only will the patient be unable to sweat due to yang deficiency, but the yang will be lost due to sweating due to yang deficiency, the treatment should take into consideration both supporting yang and replenishing qi and relieving the exterior and dispersing cold [5]. This prescription uses astragalus, ginseng, and aconite to replenish qi and support yang. It can not only enhance the potency of the medicine to help the pathogens go out, but also prevent yang from being lost due to sweating [5]. Cinnamomum twig, Asarum, Qianghuo, Ligusticum chuanxiong, Fangfeng can dispel wind and dispel cold, so as to relieve the symptoms and expel evil [5]. Peony and Ying, stir-frying will reduce the cold nature, and control the dryness of Fu, Gui, Qiang, Xin and other pungent drugs; simmering ginger warms the stomach, and jujube nourishes the spleen. Together they can increase the Qi of the spleen and stomach, regulate the Ying and Wei, and resource the source of sweat. [5]. Licorice is sweet and soothing, which prevents excessive sweating. It is also used to calm the body and regulate medicine [5]. Such a compatibility can strengthen the body without retaining evil, and induce sweating without damaging the body. They complement each other and are just right [5]. 4.6 Usage
Zaizao Powder is mainly used clinically to treat those who are usually weak and often feel chilly, cold limbs, drowsy and weak, and also feel wind-cold, which manifests as aversion to cold, fever, severe cold and mild heat, and no sweating in the limbs. Patients with cold, deep and weak pulse, or floating and weak pulse are those with the syndrome of yang deficiency, exogenous wind and cold, as described in traditional Chinese medicine [4].
Addition and subtraction: If you have a cough with phlegm, add almonds, farsia, and platycodon to clear the lungs, relieve cough and resolve phlegm; for those with sore limbs due to wind-cold and dampness, add atractylodes and Duhuo to clear away dampness and unblock meridians. Pain relief[4].
Notes on use: This prescription has relatively warm and dry properties. It should not be used if there is blood deficiency, coldness or the onset of febrile diseases [4]. 4.7 Modern indications
[5]
Zaizao Powder is suitable for treating colds, rheumatoid arthritis and other diseases in the elderly with symptoms of weak Yang Qi and exogenous wind-cold. 4.7.1 Colds
The elderly generally have reduced immune function, poor body defense capabilities, reduced metabolic functions, reduced gastrointestinal digestion and absorption functions, and are often combined with cardiovascular dysfunction. The elderly have reduced tolerance to hypoxia and antioxidant capacity, so once they become ill, their body's compensatory capacity will inevitably be insufficient. 70% to 80% of colds are caused by viruses, most commonly rhinovirus, coronavirus, influenza or parainfluenza virus, respiratory syncytial virus, adenovirus, and echovirus. Bacterial infection can be directly or secondary to viruses. After infection, it is followed by hemolytic Streptococcus, Haemophilus influenzae, Streptococcus pneumoniae, and Staphylococcus aureus. During the onset of the disease, the mucous membranes of the nose, pharynx, tonsils, and larynx are congested, red, swollen, exuded, and epithelial cells are necrotic and shed, resulting in symptoms such as runny nose, cough, and sore throat. 4.7.2 Rheumatoid Arthritis
Rheumatoid arthritis is rare in recent years and is mostly an immune response disease that occurs after infection with Group A beta-hemolytic Streptococcus. First of all, the antigenicity of this bacterium is complex, and various antigen molecular structures have homology with the body's organ antigens. The body's anti-Streptococcus immune response can produce immune cross-reactions with human tissues, leading to organ damage. The capsule is composed of hyaluronic acid. , has the same antigenicity as human joints and synovium. Secondly, streptococcal antigen-simulated autoantigens and anti-streptococcal antibodies form circulating immune complexes that deposit on the synovial membrane of human joints, activating complement components to produce inflammatory lesions. Third, the proliferation response of peripheral blood lymphocytes to streptococcal antigens is enhanced, the leukocyte movement inhibition test induced by streptococcal antigens is enhanced, the killing function of NK cells is enhanced, and the abnormal immune response of human tonsillar monocytes to streptococcal antigens can lead to inflammation. reaction. Fourth, Group A Streptococcus can also produce a variety of exotoxins and enzymes, which are directly toxic to joints and can also cause inflammatory reactions. Others believe that the disease is related to genetic factors. The main pathological changes are serous fluid and a small amount of fibrin exudation in the joint cavity, synovial congestion and edema, mucinous degeneration, fibrinoid degeneration and inflammatory cell infiltration in the subsynovial connective tissue. The exudate is easily absorbed, and generally there is no joint. The main clinical manifestations of deformity are symmetrical, migratory redness, swelling, heat and pain in large joints. The etiology of migraine is unknown and may be related to genetic, endocrine, metabolic, diet, and mental factors. Traditional vascular theorists believe that it is related to abnormal intracranial vasoconstriction function; the neurovascular hypothesis believes that primary brainstem neuronal dysfunction causes Caused by changes in cerebral blood flow; another theory is that it is related to abnormalities in serotonergic neurons, and its main clinical manifestations are pulsating headache on one or both sides. 4.8 Pharmacological effects of Zaizao Powder
[6] 4.8.1 Effect on immune function
The ginsenosides contained in ginseng promote the differentiation and maturation of lymphocytes by increasing cAMP, and then promote lymphatic transfer, which promotes the immune function of the spleen and increases the response of spleen T cells to ConA. Proliferation reaction, promote the production of IL2 and improve the activity of spleen NK cells. Ginseng flower saponins can promote the phagocytosis function of the reticuloendothelial system, and anaxatriol saponins can promote the production of IL1; ginseng polysaccharides can induce tumor necrosis factor in vivo and have anti-tumor necrosis factor. Complement activity. In short, ginsenosides and polysaccharides are the active ingredients of ginseng in regulating immune function. Ginseng can increase serum IgA, IgG, and IgM levels, which can not only promote humoral and cellular immune functions, but also improve non-specific immune functions. Ginseng is not only beneficial to normal animals It also has the effect of improving immune function in animals with low immune function. Aconite, like ginseng, has a significant promoting effect on both cellular immunity and humoral immunity. Aconite injection can significantly promote the increase in the number of antibody-forming cells and the production of serum antibodies in mice caused by sheep red blood cell immunity, and significantly increase the complement content; it can promote T Cellular RE rosette formation and lymphoblastoid transformation.
Astragalus and the astragalus polysaccharide and astragalus saponin A it contains have a wide range of effects on the immune system, mainly immune enhancement and immune regulation. The astragalus polysaccharide contained in astragalus inhibits the function of suppressive T cells, causing other T cell subpopulations such as helper The function of T cells is enhanced, thereby promoting T cell differentiation and maturation, and significantly increasing their activity; Astragalus injection can increase the phenotypes of CD3, CD4, CD8 and other T cells in the blood, and can correct their inhibitory state; Astragalus polysaccharide Through T cell mediation, it can also significantly promote the production of specific antibodies. In particular, the IgA and IgG levels in cold patients are significantly increased. This regulatory effect of humoral immunity has a biphasic effect, that is, astragalus can promote it in those with low responses, and in those with strong responses. Then suppress it. Astragalus also has a significant effect on inducing interferon. Especially after cold patients are treated with astragalus, it can be seen that the ability of peripheral blood WBC to induce interferon from viruses is significantly improved. Therefore, through this effect, astragalus has a certain secondary antiviral effect. Effect; It can also promote the activity of NK cells by inducing interferon, and this activity also has a biphasic regulatory effect; Astragalus can activate the phagocytic and bactericidal functions of surrounding leukocytes, activate macrophages, and enhance their bactericidal ability. Fengfeng can significantly increase the percentage of macrophage phagocytosis and has a significant inhibitory effect on delayed-type hypersensitivity reactions. Peony is also a good immunomodulator. It has a biphasic regulatory effect on humoral immunity, cellular immunity and non-specific immune functions. It also has a biphasic regulatory effect on the phagocytosis of macrophages and leukocytes. It has a biphasic regulatory effect on immune hyperfunction. For those with low immune function, it can be suppressed, and for those with low immune function, it can be enhanced to restore the balance of immune function. Guizhi can inhibit the release of histamine and other mediators from mast cells caused by IgE antibodies, and has anti-allergic effects. Qianghuo can promote the phagocytosis of whole blood WBC, increase the peripheral blood lymphocyte transformation rate and the percentage of red blood cell immune C3b receptor rosettes and immune complex IC rosettes. Ligustrazine can enhance the phagocytic function of monocytes, increase the lymphocyte transformation rate, increase the ANAE percentage, and promote the formation of SRBC antibodies. Asarum has inhibitory effects on both humoral and cellular immunity. Its water extract can reduce the release of allergic mediators in immediate allergic reactions by 40% and has anti-allergic effects. Ginger can improve immune function, increase organ index, increase macrophage phagocytosis rate, and antagonize 5HT. Jujube can significantly improve the function of the monocyte-macrophage system, promote hemolysin and hemolytic plaques, promote lymphocyte transformation, increase the decomposition of peripheral blood lymphocytes, promote lymphocyte proliferation, and at the same time have an antagonistic effect on type I allergic reactions. Licorice not only induces interferon, enhances NK cell activity and anti-allergic effects, but also increases the weight of the spleen and thymus; licorice Lx can reduce the amount of antigens, inhibit antibody production, and has the effect of preventing and treating penicillin allergic shock; glycyrrhizin can Enhance the ability of lymphocytes to secrete IL2 induced by ConA; inhibit the release of histamine from mast cells, inhibit the release of histamine from mast cells induced by IgE and compound 48/80; sodium glycyrrhetinate can increase the lymphocyte ratio; licorice polysaccharide can improve the reticular Endothelial system and monocyte phagocytosis; β-glycyrrhetinic acid is an inhibitor of the human complement classical pathway. In summary, most of the medicinal flavors in this prescription have a positive impact on immune function, restoring or activating non-specific immune function, and biphasically regulating humoral or cellular immunity, enhancing those with low immunity and suppressing those with overly strong immunity. , so that the body can achieve immune balance, which is undoubtedly beneficial to elderly patients. 4.8.2 Anti-aging, antioxidant, and anti-hypoxia effects
Lipid peroxidation is an important factor in human aging. Ginseng contains many substances such as maltol, ginseng polyacetylene, and ginseng ethanol saponins. They all have obvious anti-lipid peroxidation effects. Ginseng has an inhibitory effect on monoamine oxidase in the brainstem, thus preventing aging; ginseng can increase the activity of SOD and GHSPx, scavenge free radicals in the body, and protect biological membranes from free radical damage. , therefore it has the effect of resisting oxidative damage, and can convert non-dividing cells in the aging cell population into dividing cells, and shorten the cell division cycle; ginseng can also promote learning and memory functions, eliminate and protect bone marrow hematopoietic function, Therefore it plays an important role in anti-aging. Aconite can inhibit lipid peroxidation and delay aging. Aconite in aconite has a significant antioxidant effect, can eliminate superoxide anions and inhibit lipid peroxidation; aconite can also promote the respiration of gray and white matter in the brain. , promote cerebral cortex glucose oxidation and other effects. Astragaloside and total flavonoids of Astragalus are the active ingredients of Astragalus' antioxidant effect. They can significantly increase the SOD of red blood cells, so they have obvious anti-free radical damage and anti-lipid peroxidation effects. At the same time, in vitro culture has proven that Astragalus can make human fetal kidney cells grow. The vigorous time is extended, and it can prolong the natural aging process of human fetal lung diploid cells, extending the aging life span from the original 6 generations to 88 to 98 generations, and at the same time, it can promote the growth of blood cells. Qianhuo can selectively increase cerebral blood flow. White peony significantly prolongs the survival time of mice under decompression and hypoxia and reduces oxygen consumption. Total glucosides of white peony and total glucosides of paeony can significantly inhibit RBC damage hemolysis caused by H2O2, and are effective against superoxide anions and hydroxyl radicals. scavenging effect, thereby exerting antioxidant and anti-aging effects. Ginger extract can scavenge oxygen free radicals and hydroxyl free radicals, significantly inhibit hemolysis caused by H2O2, inhibit the production of MDA in liver tissue, and has anti-oxidative damage effects.
In addition to the function of improving cardiovascular function and blood rheology, Chuanxiong contains sodium ferulate, which has a significant elimination effect on superoxide anions and hydroxyl radicals generated in aqueous solution systems, and can directly capture free radicals. Asarum volatile oil has the ability to scavenge superoxide anions and inhibit lipid peroxidation. Jujube polysaccharide can increase blood SOD and CAT activity, reduce LPO levels in plasma, brain, and liver, scavenge free radicals, and has anti-aging effects. Arbutocoumarin A in licorice can scavenge oxygen free radicals, and glycyrrhizone and licoriceurone can inhibit hemolysis caused by H2O2. 4.8.3 Effects on the heart, circulation, and hemorrheology
Ginseng can increase coronary blood flow, dilate coronary arteries, increase myocardial contractility, slow down the heart rate, increase cardiac output, and has a beneficial effect on myocardial insufficiency. It has a protective effect on myocardial damage caused by reperfusion after oxygen; ginseng can also reduce the volume of myocardial infarction and improve myocardial ischemia caused by pituitary hormone; ginseng has a biphasic regulating effect on blood pressure, which can improve the blood pressure of patients with hypertension. It can also increase blood pressure in patients with hypotension and shock. Small doses of ginseng can increase blood pressure, while large doses can lower blood pressure and have anti-shock effects. At the same time, ginseng can inhibit platelet aggregation, inhibit atherosclerosis and thrombosis. Aconite has obvious cardiotonic effects on both normal and failing hearts, and can increase myocardial contractility, cardiac output and heart rate; Aconite n-butanol extract and water extract also have It has anti-arrhythmic effects. The aconite contained in it can dilate coronary arteries and increase nutritional blood flow in myocardium, and can significantly resist myocardial ischemia caused by pituitary hormone. Aconite has anti-arrhythmic effects on cardiogenic shock and endotoxin. Shock caused by various causes such as sexual shock has an antagonistic effect, which can enhance myocardial contractility, increase blood pressure, and improve circulation. At the same time, aconite can also dilate blood vessels, increase blood flow, improve blood circulation and resist shock, inhibit coagulation function, and have anti-thrombotic effects. Astragalus has a positive inotropic effect similar to that of digitalis, which increases the amplitude of cardiac contraction and output, which is more obvious for poisoned and fatigued hearts. It also strengthens the energy metabolism of myocardial cells and resists myocardial ischemia caused by pituitaryin. , resists myocardial hypoxia and arrhythmia, and has a protective effect on myocardium; it can dilate peripheral blood vessels, directly dilate cerebral blood vessels, peripheral blood vessels, coronary arteries, and superior mesenteric arteries, improve microcirculation, and also has a biphasic regulatory effect on blood pressure, reducing low blood pressure. It can increase the blood pressure of patients with blood pressure and shock, and can reduce the blood pressure of patients with hypertension to normal levels; Astragalus inhibits platelet adhesion and aggregation, inhibits thrombosis, reduces the specific viscosity of whole blood, shortens the electrophoresis time of red blood cells, and improves blood rheology. Guizhi decoction can increase coronary blood flow, increase myocardial nutritional blood flow, increase myocardial SOD activity, reduce LPO production, reduce the incidence of ischemia-reperfusion ventricular fibrillation, expand peripheral blood vessels, improve microcirculation, and reduce plasma fibrinogen content. , reduce blood viscosity, inhibit platelet aggregation, and have anti-thrombin effect. White peony root can dilate blood vessels, increase myocardial nutritional blood flow, inhibit platelet aggregation, reduce the wet weight of platelet thrombus, and inhibit thrombosis. Asarum not only has positive inotropic and positive frequency effects, but also increases coronary blood flow and has a protective effect on hypoxic myocardial injury; asarum can increase the mean arterial pressure and left ventricular arterial pressure of animals in shock, and reduce the central Arterial pressure; Asarum volatile oil has antihypertensive effects. Qianghuo also has the effect of dilating coronary arteries, increasing coronary nutritional blood flow, improving myocardial ischemia, and also has anti-arrhythmic effects; Qianghuo water decoction and alcohol precipitate can significantly reduce the viscosity of whole blood, inhibit platelet aggregation, and inhibit platelet aggregation. The formation of thrombus and fibrin thrombus, thus has a good effect on improving blood rheology. Ligusticum chuanxiong is a new type of calcium ion antagonist. It not only has the effects of significantly enhancing myocardial contractility, dilating coronary arteries, increasing coronary blood flow, and reducing myocardial oxygen consumption, but also has a protective effect on myocardial ischemia-reperfusion injury. It can inhibit ischemic pulmonary vasoconstriction and right heart hypertrophy, and has a therapeutic effect on pulmonary hypertension. At the same time, it can expand small arteries, improve microcirculation, protect vascular endothelial cells, inhibit atherosclerosis, inhibit platelet aggregation, and prevent thrombosis. The gingerol contained in ginger is a cardiotonic, which can increase myocardial contractility and produce three-phase effects on blood pressure: transient reduction, significant increase, and sustained increase in blood pressure. Licorice flavonoids have antagonistic effects on arrhythmias caused by various causes. Glycyrrhetinic acid has angiotensin II AT1 receptor agonist-like effects. Sodium glycyrrhetinate can reduce the scope of myocardial infarction. Glycyrrhizin has anticoagulant and antithrombotic properties. , inhibiting platelet aggregation. In summary, this prescription can significantly improve heart function, circulatory function, and blood rheology. 4.8.4 Anti-pathogenic microorganisms
Astragalus has broad-spectrum and effective antiviral capabilities by inducing interferon, especially against influenza virus, herpes simplex virus, coxsackie B2 virus, and Newcastle disease virus. It has obvious inhibitory effects on many viruses; by promoting NK cell activity, it can enhance the bactericidal function of the spleen. Cinnamon twig alcohol extract has a certain inhibitory effect on Staphylococcus aureus, pneumococcus, Escherichia coli, Proteus, Shigella dysenteriae, and typhoid bacilli; cinnamon twig decoction has an inhibitory effect on influenza viruses and orphan viruses.
Peony decoction also has direct antiviral effect, strong antibacterial effect and broad antibacterial spectrum, and is effective against Shigella dysenteriae, hemolytic Streptococcus, viridans Streptococcus, Bordetella pertussis, Vibrio cholerae, Streptococcus pneumoniae, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and some fungi such as Trichophyton viruliferous, Flavophyton xanthophyton, Epidermophyton rubrum, etc. have inhibitory effects. In addition to its inhibitory effect on the above-mentioned bacteria, asarum also has antibacterial effects on 16 species of fungi such as Aspergillus flavus. It also has inhibitory effects on most Gram-positive bacteria and Bacillus subtilis; Inhibits the proliferation of cellular viruses. In addition to their inhibitory effects on most of the above-mentioned bacteria, Ligusticum Chuanxiong and Qianhuo also have certain inhibitory effects on Brucella, Bacillus subtilis, and Bacillus cereus. Fengfeng has an inhibitory effect on some of the above-mentioned bacteria and fungi, and Ligusticum chuanxiong has a significant inhibitory effect on Pseudomonas aeruginosa, Paratyphi, Vibrio cholerae, and Gram-negative bacilli. Fengfeng has an inhibitory effect on Colombian SK virus. In addition to its inhibitory effect on most of the above-mentioned bacteria, ginger also has varying degrees of inhibitory effects on Vibrio cholerae, Salmonella, Staphylococcus albus, Trichophyton rubrum, Trichophyton violarum and other fungi, and Trichomonas trichomonas. Killing effect. In addition to the inhibitory effect on some of the above-mentioned bacteria, licorice has an inhibitory effect on Helicobacter pylori, it also has an inhibitory effect on amoeba and trichomoniasis, and it has an insecticidal effect on Clonorchis sinensis; at the same time, it has an inhibitory effect on a variety of viruses. The direct effect of particles and the indirect effect of inducing interferon, increasing the activity of NK cells and macrophages, activating the host immune function, and exerting a broad-spectrum antiviral effect; glycyrrhizinic acid monoamine can inactivate HIV; glycyrrhizinic acid has a broad-spectrum antiviral effect on coxsackie Viruses, adenovirus, and syncytial virus have strong inhibitory effects; licorice polysaccharide can inhibit vesicular stomatitis virus, type I herpes simplex virus, and vaccinia virus; glycyrrhizin, in addition to inhibiting the above viruses, also has an inhibitory effect on hepatitis Viruses are suppressed. It can be seen that this prescription can play an anti-infective effect on colds, whether it is common cold or influenza. 4.8.5 Anti-inflammatory and analgesic effects
Ginsenoside R0 has a significant inhibitory effect on both acute and chronic inflammation, and can significantly eliminate edema and reduce the concentration of hydroxyproline in inflammatory tissues. Aconite has a significant anti-inflammatory effect, and has a significant inhibitory effect on the hyperpermeability of capillaries, edema, exudation, and granulation tissue hyperplasia of inflammation. It also has an analgesic effect; Astragalus polysaccharide has significant anti-inflammatory and analgesic effects. Sedative effect; astragalus saponin can significantly inhibit capillary permeability, increase inflammatory exudation, inhibit WBC swimming, reduce the 1L8 content in the exudate, reduce the NO content in the exudate, reduce the generation of oxygen free radicals, and reduce PGE2 content in inflammatory tissue. Total glycosides of paeony have a significant inhibitory effect on both specific inflammation and non-specific inflammation, and have varying degrees of inhibitory effects on multiple aspects of inflammation such as capillary permeability, edema, and hyperplasia. It also has a significant inhibitory effect. Pain and sedation. The cinnamaldehyde contained in cinnamon twig has obvious analgesic and sedative effects; cinnamon twig has an inhibitory effect on multiple links of inflammation, and has a significant inhibitory effect on inflammatory exudation, edema, and granulation tissue hyperplasia. In addition to enhancing the function of the adrenal cortex, the volatile oil of Asarum also inhibits the release of inflammatory mediators, connective tissue proliferation and other aspects of the inflammation process. It has anti-inflammatory mediators, anti-oxidation, and free radical scavenging effects. It also inhibits superoxide anions. The induced depolymerization of hyaluronic acid and aminopolysaccharides in synovial fluid has a protective effect and also has a central analgesic effect. Qianghuo volatile oil and water extract can significantly inhibit capillary permeability and increased exudation, inhibit granulation tissue proliferation, and inhibit inflammation in delayed-type allergic reactions. At the same time, it can increase the pain threshold and exert an analgesic effect. The volatile oil of Ligusticum chuanxiong has a sedative effect, while Ligustrazine has a significant analgesic effect. Parsnip has anticonvulsant properties. Ginger has anti-inflammatory and analgesic effects. Ginger has a significant inhibitory effect on the early and late stages of inflammation, and it also has analgesic effects. Jujube has a sedative effect. Licorice has hydrocortisone-like anti-inflammatory effects, inhibiting the I, II, and III stages of inflammation, inhibiting inflammatory exudation, edema, and granulation tissue hyperplasia, and also inhibiting immune inflammation; licorice FM100 also has sedative and analgesic effects, as well as anti-allergic effects and inhibits allergic inflammation. It can be seen that this prescription can exert an inhibitory effect on various stages and links of inflammation. 4.8.6 Antipyretic effect
Guizhi decoction and the cinnamic aldehyde, asarum volatile oil, nodule volatile oil, and windproof decoction contained in it have obvious antipyretic and cooling effects. Ginger also has significant antipyretic properties. Human body surface area calculator BMI index calculation and evaluation Female safe period calculator Pregnancy date calculator Normal weight gain during pregnancy Safety classification of medication during pregnancy (FDA) Five elements and eight characters Adult blood pressure evaluation Body temperature level evaluation Diabetes diet recommendations Common clinical biochemistry units Conversion to basal metabolic rate Calculate sodium supplementation calculator Iron supplementation calculator Commonly used Latin abbreviations for prescription Quick check Common symbols for pharmacokinetics Quick check Effective plasma osmolarity calculator Ethanol intake calculator
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In addition to its antipyretic, sedative, and analgesic effects, this prescription also has a positive impact on the brain and endocrine functions.
Among them, ginseng can promote the synthesis of RNA and protein in the brain; promote the synthesis and release of the neurotransmitter Ach in the brain, increase the content of DA and NA in the brain; promote the development of nerve cells, increase brain weight and cerebral cortex thickness, and increase the CA3 area of ??the hippocampus. The number of synapses in the upper layer of pyramidal cells improves the function of neurons in the hippocampus; it protects nerve cells and reduces the death rate of nerve cells; it increases blood and oxygen supply to the brain and improves energy metabolism, thus improving the brain's memory and learning abilities and improving brain nerves. The ability to regulate excitement and inhibition can balance inhibition and excitement, restore disordered neural activity to normal, improve the flexibility of neural activity, and improve mental work efficiency; ginseng can excite the hypothalamus-pituitary-adrenocortical system, promote ACTH secretion, and make The synthesis and secretion of adrenocortical hormones increases, preventing the failure of adrenocortical function under stress; at the same time, ginseng can also stimulate the hypothalamus-pituitary-gonad axis, increase thyroid function, promote insulin release, and promote the metabolism of the three major substances. Many functions of astragalus are similar to ginseng. It also benefits intelligence, enhances memory and learning functions, promotes adrenal cortex function, expands cerebral blood vessels, increases cerebral blood flow, and promotes brain cell development. Aconite can increase cerebral blood flow, and can excite the hypothalamus-pituitary-adrenocortical system, causing a dose-dependent increase in the content of adrenocorticotropin-releasing hormone in the hypothalamus. Aconite itself also has corticosteroid-like effects. Asarum has ACTH-like effects and can enhance the function of the adrenocortical system. Qianhuo not only selectively increases cerebral blood flow, but also exerts anti-inflammatory effects by stimulating the pituitary-adrenocortical system. Ligustrazine contained in Ligusticum chuanxiong can dilate cerebral blood vessels, improve brain and meningeal circulation, increase cerebral blood flow, protect the activity of Ca2+Mg2+ATPase in brain cell membranes, reduce Ca2+ overload in brain cells, and improve mitochondrial membrane flow in ischemic brain. It has a preventive and therapeutic effect on brain damage. It can also reduce MDA content, increase the activity of SOD and GHSPx in the brain, and has antioxidant effects. Ligusticum chuanxiong volatile oil has an exciting effect on the vasomotor center, respiratory center and spinal cord reflex center of the brain oblongata. Total glycosides of paeony are functionally dependent on the hypothalamus-pituitary-adrenal axis. It can have a biphasic regulatory effect on the pituitary-adrenal axis depending on temperature and other conditions, and further exert a biphasic regulatory effect on immune function and inflammation. Ginger can promote the release of catecholamines from the adrenal medulla. Total flavonoids of licorice have a protective effect on cerebral ischemia-reperfusion injury; glycyrrhizic acid can increase the activity of brain ATPase and lactate dehydrogenase and reduce brain edema. At the same time, licorice can also stimulate the hypothalamus-pituitary-adrenocortical axis to produce adrenocortical hormones. Similar effects, and licorice can promote the synthesis of corticosteroids; glycyrrhetinic acid is structurally similar to corticosteroids. It not only has direct corticosteroid-like effects, but also competitively inhibits the metabolic inactivation of corticosteroids in the liver, thereby increasing blood corticosteroids. concentration.
It can be seen that all 12 herbs in this prescription have effects on the nervous and endocrine systems, and 8 of them have stimulating effects on the hypothalamus-pituitary-adrenal axis, which not only promotes antipyretic, anti-inflammatory, and The functions of water, salt and substance metabolism, and more importantly, the "allowing" effect of adrenocortical hormones restore the balance of the nervous and endocrine regulatory functions of the whole body. 4.8.8 Effect on digestive system function
Both ginsenoside R0 and oleanolic acid can inhibit liver cell damage, and ginseng polysaccharide has an inhibitory effect on a variety of experimental gastric ulcers. Astragalus decoction can inhibit the reduction of liver glycogen, promote liver protein synthesis, and restore immune function disorders caused by chronic hepatitis; Astragalus can significantly inhibit gastric mucosal damage and has anti-ulcer effects. Aconite has bile-like, histamine-like and anti-adrenergic effects, which significantly stimulates spontaneous intestinal contraction but inhibits gastric emptying. Cinnamaldehyde contained in cassia twig can promote gastrointestinal smooth muscle peristalsis and enhance digestive function; cinnamic acid also has a choleretic effect. Asarum volatile oil excites intestinal smooth muscle in small doses and inhibits it in large doses. The aqueous extract of white peony root can reduce the degree of degeneration and necrosis of liver cells, reduce ALT, and has a hepatoprotective effect. It also has anti-ulcer effects, promotes the increase of mucus secretion in the large intestine, and promotes the propulsive movement of the large intestine and small intestine. Ginger can promote the synthesis and release of endogenous PG in the gastric mucosa, and has a protective effect on gastric mucosal damage. Ginger decoction can promote gastric juice secretion, increase gastric acidity and discharge, and prevent stress ulcers. Ginger also has antiemetic, choleretic, and hepatoprotective effects. Jujube also has the effect of inhibiting liver damage. Licorice can inhibit liver damage, inhibit hepatic steatosis and liver fibrosis, protect liver cell membranes and improve liver function; licorice can directly inhibit HBV, inhibit gastric acid and gastric juice secretion, directly absorb and reduce gastric acidity, and increase gastric mucosal cell secretion. The sugar amine component protects the gastric mucosa and promotes the regeneration of gastrointestinal epithelial cells. *** The gastric mucosal cells synthesize and release endogenous PG with mucosal protection, so it has anti-ulcer effect; at the same time, licorice FM100 also has poppy-like antispasmodic properties. It can significantly inhibit intestinal spasm caused by BaCl2, histamine and acetylcholine.
It can be seen that this prescription has liver protection, choleretic, anti-ulcer effects, and regulates gastrointestinal function. 4.9 Song Jue
Zai Zao Powder uses Ginseng Fuqi, Gui Gan Qiang Fang Xiong Qi, and boils it with Asarum, Ginger and Date, which is most suitable for yang deficiency and cold syndrome [4].
4.10 Source
"Six Books on Febrile Diseases: The Method of Killing Car Hammers", Volume 3, Volume 5, "Surgery Dacheng", Volume 4, Zaizao Powder 5.1, Composition
Two halves of Sophora flavescens 8 (fried in oil), 1 tael of dry lacquer, 5 qian of licorice, and 2 taels of Chuanshanjia (fried). 5.2 Preparation method
Apply the medicine to the powder. 5.3 Function and Indications
"Surgery Encyclopedia" Volume Sifang's Zaofang Powder can treat leprosy, eyebrows, feet, and soles.
5.4 Usage and dosage of Zaizao Powder