As early as Huangdi Neijing, there were records related to febrile diseases. Baihu decoction and Chengqi decoction in Treatise on Febrile Diseases are the basis of treating typhoid fever in later generations. However, in a long historical period, febrile diseases could not get rid of the shackles of the theoretical system of mild typhoid fever.
Liu Hejian in the Jin Dynasty advocated the method of relieving exterior syndrome by pungent and cool, and founded the school of cold and cool. In the Ming Dynasty, Lv Wang further distinguished typhoid fever from fever. Wu Youke thinks that the etiology of epidemic febrile diseases is hostile, which marks the establishment of the theory of epidemic febrile diseases.
Ye founded the dialectical theory of harmony in Qing Dynasty, which clarified the law of occurrence and development of epidemic febrile diseases and promoted the maturity of epidemic febrile diseases.
The differentiation of Wei-qi and Ying-blood was founded by Ye, and the pathological process of epidemic febrile diseases was divided into four stages: Wei-fen, Qi-fen, Ying-fen and Blood-fen. Wei-fen syndrome is the onset of epidemic febrile disease, which belongs to the exterior and the condition is mild; The syndrome of qi differentiation is that warm pathogens enter from the exterior to the interior, and pathogenic potential erupts; Syndrome differentiation of nourishing blood is the key stage of pathogenic heat deepening, yin blood exhaustion and mental injury.
Using the principles and prescriptions of epidemic febrile diseases, modern medical diseases such as Japanese encephalitis, epidemic hemorrhagic fever, leptospirosis, intestinal typhoid fever, pneumonia, measles, etc., have achieved good results.