The earliest recorded epidemic in China can be traced back to cholera in 674 BC, and there were no fewer than 500 epidemics in the Opium War. In the long-term struggle against infectious diseases, Chinese medicine has been continuously developed and improved, forming its own theoretical system for understanding epidemics and accumulating valuable experience in disease prevention and treatment.
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The oldest existing cholera record occurred around 300 BC. Later, China in the 7th century and Java in 17th century also recorded vicious plagues that were considered as cholera, and the worldwide epidemic began at 18 17. At present, it is generally believed that the birthplace of cholera is in the lower reaches of Ganges River in Bangladesh, India and its border with Bangladesh. Cholera broke out in Kolkata on 18 17 and spread throughout Asia and Africa until 1823.