2 English reference induced resuscitation drugs
3 English translation orifice opened medicine
A medicine with fragrant taste and resuscitation effect is used for the emergency treatment of delayed unconsciousness/syndrome.
All drugs whose main function is to awaken consciousness are called resuscitation drugs, which are suitable for the syndrome of blindness caused by pathogenic factors. The main manifestations of the syndrome are coma, gnashing teeth and clenching fists. Because of the different symptoms at the same time, it can be divided into heat closure and cold closure. Heat closure has symptoms such as high fever, delirium, rapid pulse and convulsion; Common in some serious systemic infections such as epidemic cerebrospinal meningitis, high fever coma caused by Japanese encephalitis, some cerebrovascular accidents, epilepsy, hepatic coma, heatstroke and so on. Treatment should be combined with resuscitation drugs and heat-clearing and detoxification drugs, which is the so-called cold-opening method. Cold syndrome is accompanied by symptoms such as blue face, delayed pulse and white fur, which are more common in coma caused by stroke and poisoning. It is advisable to warm and enlighten the mind, and use pungent and warm drugs to promote qi. Faint mind, slight cold pulse in limbs and dripping with cold sweat are symptoms of detachment, and resuscitation drugs are not suitable.
Resuscitation drugs are used for first aid, and further treatment should be done according to different causes after waking up.
5 Pharmacological effects of resuscitation drugs Commonly used resuscitation drugs include musk, borneol, storax, camphor, Acorus gramineus and so on. Its resuscitation effect may be related to the following pharmacological effects.
5. The effect of1on the central nervous system The main manifestation of strangulation syndrome is coma, and the purpose of using resuscitation drugs is to wake up patients. The existing data show that its effect on the central nervous system is different from that of resuscitation drugs in modern pharmacology. Except camphor excites the respiratory center and the vascular movement center, the central excitatory effect of other drugs is still difficult to determine. Angong Niuhuang Pill, Niuhuang Xingnao Injection and Acorus gramineus aqueous solution can reduce spontaneous activity of mice, prolong sleep time of barbiturates and show sedative effect. Angong Niuhuang Pill and Acorus gramineus aqueous solution can also resist the sports excitability of amphetamine, delay the seizure of pentylenetetrazol in mice and reduce the death rate of convulsion. Muscone, the effective component of musk, can reduce the spontaneous activity of mice in large doses. The effect of musk on central stimulants varies from drug to drug, but it has no effect on pentylenetetrazol and nikethamide when it works synergistically with strychnine. Repeated administration of musk and muscone can shorten the sleep time of rats caused by pentobarbital sodium, which is thought to be caused by drug-induced liver drug enzymes, thus reducing the concentration of pentobarbital sodium in blood and brain, rather than directly exciting the center. In a word, resuscitation drugs have different effects on the central nervous system, and the essence of their resuscitation effects needs further discussion. It is also reported that the absorption, distribution and excretion process of 3H borneol in the body confirmed that 3H borneol can be rapidly absorbed through intestinal mucosa, and can penetrate the blood-brain barrier within 5 minutes after administration. The accumulation time in the central nervous system is longer than that in other brain tissues, and the accumulation amount is higher, suggesting that the recovery mechanism of borneol may be related to this. Niuhuang Xingnao injection, storax and borneol can improve the hypoxia tolerance of mice, and the volatile oil of Acorus gramineus has a cooling effect, which may contribute to the improvement of central nervous system function.
Niushesan (artificial bezoar, musk, antelope horn, calamus, clove and saffron) was used to rescue hepatic encephalopathy and high fever coma, and Acorus gramineus injection was used to treat pulmonary encephalopathy, which achieved good results and could improve patients' consciousness disorder and mental and neurological symptoms. α-Asarone extracted from Acorus gramineus also has a good therapeutic effect on grand mal, reducing the number of attacks and improving EEG.
5.2 Anti-inflammatory and Antibacterial Effects Most resuscitation drugs also have the function of detumescence and pain relief, and are often used to treat sores and swelling. This effect may be related to its anti-inflammatory, antibacterial and local * * * effects. The anti-inflammatory effect of musk is clear. In the early stage of inflammation, it can inhibit the increase of vascular permeability and the migration of white blood cells and reduce edema. In the late stage of inflammation, the proliferation of granulation tissue was inhibited. Musk, borneol, storax and Acorus gramineus all have different antibacterial effects. Styrax, Borneolum Syntheticum and Camphor can slightly sense nerve endings and have analgesic and antipruritic effects. Liushen Pill and Bingpeng Powder are commonly used to treat sore throat and oral ulcer.
5.3 The experimental results of anti-angina animal show that Su Bing Dripping Pills (Styrax, Borneolum Syntheticum) can prolong the hypoxia tolerance time of mice, increase the coronary sinus blood flow of dogs with myocardial infarction, slow down the heart rate, reduce the arterial and venous blood oxygen difference, and reduce the myocardial oxygen consumption. The compound can also protect the ultrastructural changes of experimental myocardial ischemia in mice, and can resist the decrease of myocardial nutritional blood flow caused by pituitrin, thus improving the uptake rate of 86Rb in mice myocardium. Musk ether extract can reduce blood pressure and slow down heart rate in anesthetized dogs, and can resist the increase of heart rate caused by isoproterenol. The ice-increasing solution can also directly resist the contraction of isolated rabbit thoracic aorta caused by norepinephrine. The above data provide an experimental basis for the treatment of angina pectoris with some resuscitation drugs with the effects of promoting qi circulation and removing blood stasis, warming pain and dispelling cold. According to clinical observation, artificial muscone preparation and Subing dropping pills have certain curative effect on relieving angina pectoris and chest tightness.
The resuscitation drugs in the ancient book "Revision of Popular Treatise on Febrile Diseases": [Chapter 1 Essentials of Typhoid Febrile Diseases, Section 8] Acute heatstroke syndrome caused by three summer drugs. He has a dirty face and cold limbs. God fainted. Emergency use of aromatic resuscitation drugs. Such as marching troops and Zi Xue, are the most effective. It is advisable to distinguish between God and Su, and combine them according to the symptoms. ...
Key cholera is interesting: After going to the toilet, I suddenly felt cold and sweaty, and my lips were low, thinking it was a rash, and I wanted to take medicine to enlighten me. At the age of seventeen, I grabbed his arm for diagnosis, and my pulse was heartbroken by Microsoft. ...
Interpretation of Ophthalmology: [Volume II: Hengji Senile Eye Diseases] Enlighten and explain (Ma Hualong's note) The treatment of senile eye diseases should be a nourishing medicine. This side does not need to be nourished, but it must be enlightened first. Why? My young lady has been suffering from eye diseases for a long time, and she has a lot of pathogenic heat and phlegm. ...
Jian Yao: Gleditsia sinensis can draw poison away, ventilate and guide phlegm, remove swelling, and sneeze when sniffling. Now I know Xie is 1368 1644. ...
Medical knowledge: Fuzi Lizhong decoction