Why is Guizhou in a backward position in the country for a long time?

Judging from the location conditions, Guizhou is not near the sea, with undulating terrain and inconvenient transportation; There is no plain support in the territory, the land is barren, and agricultural production is backward for a long time. From the perspective of science and technology culture, Guizhou developed late, with underdeveloped science and technology culture and backward education. In terms of population, Guizhou has a high population density, with a registered population of more than 40 million, much more than Xinjiang, Inner Mongolia, Qinghai, Tibet and other big provinces, with less per capita resources and limited development. In addition, it is not attractive to talents and lacks talents; Underdeveloped education, low population quality and a large number of human resources outflow are also important reasons for Guizhou's backward development.