2 English reference Stephania tetrandra [Xiangya Medical Dictionary]
Sinomenine [Xiangya Medical Dictionary]
Terminology review committee of traditional Chinese medicine. Terminology of Traditional Chinese Medicine (2004)]
Ji Fang Root Powder [Chinese Medicine Terminology Committee]. Terminology of Traditional Chinese Medicine (2004)]
3. Overview Ji Fang is the name of traditional Chinese medicine, which comes from Shennong Herbal Classic [1]. Also known as "Korean self-defense" [2]. Dry roots of Stephania tetrandra [2].
Pharmacopoeia of People's Republic of China (PRC) (20 10 edition) records the pharmacopoeia standard of this Chinese medicine.
4 Latin name Stephania tetrandra (La) (Chinese medicine terminology (2004))
5 English name mealy Ji Fang [root] (TCM terminology (2004))
6 Ji Fang is also known as Hanfangji, Aquilaria Resinatum and Gongdi [1].
7 Source and place of origin: the root of Stephania tetrandra [1]. Location: Zhejiang, Anhui, Jiangxi and Hubei [1].
8 Sexual taste is bitter, pungent and cold [1]. Enter bladder meridian, lung meridian and spleen meridian [1].
Function 9 is mainly used for diuresis and detumescence, expelling wind and removing dampness, and dispersing carbuncle and detumescence [1].
1. Treat edema, beriberi, dyspnea caused by drinking water, dysuria, rheumatoid arthritis and hypertension [1]. Decocting: 6 ~ 10g [1].
2. Treat eczema, leg ulcer, carbuncle and furuncle [1]. Fried or pounded fresh products [1].
Stephania tetrandra is often used in ophthalmology to remove rheumatism, which has the effects of expelling wind and removing dampness, relieving pain, diuresis and detumescence.
1) is used for eye diseases caused by rheumatic fever, such as boils, pupil contraction, limb pain, etc. It is often combined with heat-clearing and dehumidifying herbs such as Coix seed, talc and silkworm excrement.
2) Used for eyelid edema, black eye edema, optometry and macular edema caused by various reasons. It can be combined with Poria, Atractylodis Macrocephala, Radix Astragali, etc.
10 chemical composition this product contains a variety of alkaloids, mainly tetrandrine (tetrandrine), tetrandrine (tetrandrine), berbamine and cyclic alkaloids [1]. It also contains flavonoid glycosides, phenols, organic acids and volatile oil [1].
Pharmacological action 1 1 tetrandrine has nonspecific calcium antagonism, which can block L calcium channel and T calcium channel [1]. It has the effects of lowering blood pressure, dilating coronary vessels and resisting arrhythmia, and has been applied in clinic [1]. It also has analgesic and anti-inflammatory effects [1]. It has antibacterial (including Mycobacterium tuberculosis) and antitumor activities [1]. Similar alkaloids have similar effects [1]. Tripterine alkaloid can relax striated muscle and block ganglion [1].
12 Ji Fang poisoned Ji Fang, also known as Stephania tetrandra, Zaijunxing, Shijie, Stephania tetrandra, Aquilaria Resinatum, Toad Potato, Pig Intestine, Ground Arch, Mountain Turtle, etc. It belongs to drugs for expelling wind, removing dampness and stopping arthralgia [3]. It is the root of Stephania tetrandra, Stephania tetrandra, Stephania tetrandra and Aristolochia, and contains tetrandrine [3]. Pharmacological effects include anti-cerebral ischemia, antipyretic, analgesic, anti-inflammatory, coronary artery dilating, blood pressure lowering, antiallergic, antiasthmatic, antiviral, antifungal, antibacterial, antitumor, anti-myocardial ischemia, anti-arrhythmia and anti-platelet aggregation [3].
Small dose of tetrandrine can excite respiratory center, while medium dose can cause clonic convulsion and dyspnea.
12. 1 mechanism of adverse reactions: Low dose can excite respiratory center, while middle dose can cause clonic convulsion and dyspnea [3]. It can inhibit the heart, slow down the heart rate, dilate peripheral blood vessels and lower blood pressure [3]. Small dose can increase the urine flow of kidney, but large dose can inhibit it, and most of them die because of respiratory system inhibition [3].
The clinical manifestations of 12.2 poisoning are pallor, vomiting, cold sweat, palpitation, weakness of lower limbs, quadriplegia or even paralysis, * * ataxia, increased muscle tone, respiratory depression, convulsion, tonic spasm, stupor and unconsciousness, and finally death due to respiratory paralysis, asphyxia and myocardial injury [3].
12.3 treatment point 1. Keep the patient in a quiet and warm environment [3]. Immediately after poisoning, gastric lavage was performed with 1: 2000 potassium permanganate solution or 2% tannic acid, and diarrhea was induced by oral magnesium sulfate [3].
2. Symptomatic treatment: if acute renal failure occurs, it should be treated as acute renal failure; If respiratory depression occurs, oxygen inhalation and respiratory center stimulants are given, and artificial respiration is given when necessary; In case of convulsion, phenobarbital sodium or diazepam should be injected intravenously immediately; People with lower limb weakness use physostigmine to resist muscle relaxation [3].
13 standard of Stephania tetrandra Pharmacopoeia 13. 1 named Stephania tetrandra.
Ji Fang
Stephania tetrandra
13.2 source this product is the dried root of Stephania tetrandra, a plant of Stephania of Menispermaceae. Dig in autumn, wash, remove rough skin, dry in the sun until semi-dry, cut into sections, and cut the big ones vertically.
13.3 characteristics this product is irregular cylindrical, semi-cylindrical or blocky, multi-curved, with a length of 5 ~ 10 cm and a diameter of 1 ~ 5 cm. The surface is grayish yellow and often falls into the transverse groove at the bend, forming a nodular tumor. Heavy, solid, flat section, gray-white, rich in powder, with sparse radial texture. Slight breathing and bitterness.
13.4 Identification (1) Cross section of this product: cork layer sometimes remains. There are scattered stone cell groups in the inner layer of suppository, which are often arranged tangentially. The phloem is wider. Form a layer, form a ring. Xylem is the majority, with a wide radiation area; Catheters are rare and arranged radially; There are wood fibers beside the catheter. The parenchyma cells are filled with starch granules, and fine rod-shaped calcium oxalate crystals can be seen.
(2) Take 65438+0g of this product powder, add 65438±05ml of ethanol, heat and reflux for 65438+0h, cool, filter, evaporate the filtrate, and dissolve the residue with 5ml of ethanol as the test solution. In addition, tetrandrine reference substance and tetrandrine reference substance were taken, and chloroform was added to make a mixed solution containing 1ml as a force reference solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia Part I, 20 10), absorb the above two solutions, each 5μ 1, and spot them on the same silica gel G thin-layer plate, with chloroform-acetone-methanol 5% concentrated ammonia solution (6: 1: 0. 1) as the development. In the chromatogram of the test sample, spots with the same color appear in the position corresponding to the chromatogram of the control sample.
The water content of 13.5.1shall not exceed 12.0% (the first method in appendix ⅸ h of Pharmacopoeia 20 10).
13.5.2 The total ash content shall not exceed 4.0% (Appendix ⅸ k of Pharmacopoeia 20 10).
13.6 the extract shall be determined by the hot dip method under the Determination of Alcohol-Soluble Extracts (Appendix ⅹ a of Pharmacopoeia I, 20 10), with methanol as the solvent, and the content shall not be less than 5.0%.
The content of 13.7 was determined by high performance liquid chromatography (appendix ⅵ D of Pharmacopoeia I, 20 10 edition).
13.7. 1 chromatographic conditions and system applicability test: octadecylsilane bonded silica gel is used as filler; The mobile phase was acetonitrile-methanol-water-glacial acetic acid (40: 30: 30:1) (0.41g sodium dodecyl sulfonate/100 ml); The detection wavelength is 280 nm. According to the peak of tetrandrine, the theoretical plate number should be not less than 4000.
13.7.2 preparation of reference solution take a proper amount of tetrandrine reference substance and tetrandrine reference substance, weigh them accurately, and add methanol to make a mixed solution containing tetrandrine 0. 1mg and tetrandrine 0.05mg per 1ml respectively.
13.7.3 preparation of test solution take about 0.5g of this product powder (pass through No.3 sieve), weigh it accurately, add 25ml of 2% methanol hydrochloric acid solution, weigh it, heat and reflux for 30min, let it cool, weigh it again, make up the weight loss with 2% ethanol hydrochloric acid solution, shake it evenly, filter it, and weigh 5ml of filtrate accurately.
13.7.4 determination method Accurately suck the control solution and the test solution 10μl respectively, inject them into the liquid chromatograph, and determine to obtain the product.
The total amount of tetrandrine (C38H42N206) and tetrandrine (C37H40N206) in this product shall not be less than 65438 0.6%.
13.8 Fangji decoction pieces 13.8. 1 Processing to remove impurities, microbubble, washing, fully wetting, cutting into thick slices and drying.
This product is a round or semi-circular thick tablet. The skin is grayish yellow. The section is grayish white, powdery and sparse in radial structure. Slight breathing and bitterness.
13.8.2 The total amount of tetrandrine (C38H42N206) and tetrandrine (C37H40N206) shall not be less than 1.4%.
13.8.3 Identification of the same medicinal materials (except cross section).
13.8.4 Check the same medicinal materials.
13.8.5 The extract is the same as the medicinal material.
13.8.6: Bitter taste and cold. It belongs to bladder meridian and lung meridian.
13.8.7 Functions and indications: expelling wind and relieving pain, promoting diuresis and reducing swelling. For rheumatism, edema, beriberi, dysuria, eczema and sores.
13.8.8 Usage and dosage 5~ 10g.
13.8.9 Store in a dry place to prevent mildew and moth.
13.9 Source