Does lymphatic factor play a role in the proliferation and differentiation of B cells into plasma cells and memory cells?

The activation, proliferation and differentiation of B cells need two signals: antigen signal and activated T cell signal. Antigen signal: the antigen recognition receptor on the surface of B cell recognizes antigen as the first signal to produce B cell activation. Some people say that B cells combine with antigen-sensitized B cells. Activated T cell signal: Activated T cells refer to helper T cells, which are provided by other molecular signals instead of presenting antigens, and refer to cytokines secreted by T cells.

It is also clearly pointed out in General Biology that when the two arms of antigen recognition receptor molecules on the surface of B cells meet the corresponding antigens and lock in the binding site, this B cell is sensitized and ready to start dividing. But it needs other suitable signals to divide, and these signals come from an activated helper T cell. Activated T cells secrete interleukin -2, which promotes the division of sensitized B cells.

It is now clear that T cells cannot transmit antigens, and the differentiation and proliferation of B cells must be lymphatic factor.