1. Shennong Herbal Classic: "It tastes sour and flat. Cold and heat control the heart, accumulation of pathogenic factors, soreness of limbs and dampness. I have served An Musashi for a long time. "
2. Compendium of Materia Medica: "Sweet and sour, nourishing the liver and gallbladder. Stir-fried, sour, warm and fragrant, and can also wake up the spleen. Help Yin Qi, strengthen bones and muscles, solve troubles, quench thirst and sweat. "
3. "Records of Famous Doctors": "The main worry is that I can't sleep, my umbilicus aches up and down, my blood turns to drain for a long time, I sweat out my thirst, tonify the middle energizer, benefit the liver qi, strengthen my bones and muscles, help Yin Qi, and make people fat and healthy."
4. "Materia Medica Reading": "Enter the liver to hide the soul, and use it to cure timidity and insomnia; If you are worried, you will be able to treat sweating due to excessive fluid retention. Sex is quite smooth and tastes sweet. "
5. "The Theory of Medicinal Properties": the main bone and muscle wind, the soup is served at the end of frying.
6. "Herbal semi-elegant": "Acid and nontoxic. Cold and heat dominate the heart, pathogenic factors accumulate, limbs are sore and wet. Take the five internal organs for a long time. "
7. Supplement to Materia Medica: "Sleep more, don't sleep and fry."
8. "Compendium of Materia Medica": "The taste is sweet, sour and moist. At first, it is less yin and less yang, mainly to soothe the nerves, and ginseng and poria cocos are used to treat night sweats; Take cinnabar and frankincense to treat insomnia due to gallbladder deficiency. "
9. "Materia Medica Yan Hui": "Gathering qi to soothe the nerves, nourishing tendons and replenishing marrow, harmonizing the stomach and transporting the spleen."
10. "New edition of Materia Medica": "Ziziphus jujuba seeds are sour, flat and non-toxic. Into the heart, liver, gallbladder and collaterals. Calm the heart, soothe the nerves, benefit the liver and gallbladder, replenish the middle energizer, astringe the sweating, remove the annoyance and quench the thirst, soothe the five internal organs, stop the pain of hands and feet, strengthen the bones and muscles, and prolong life after long service. "
1 1. "Herbal rejuvenation": "calming the liver and regulating qi, moistening the lungs and nourishing yin, warming the middle warmer and promoting diuresis, astringing qi to stop sweating, benefiting the mind, being alert and improving eyesight."
12. Readable materia medica: "Acid, pungent, nontoxic. Drugs for foot Jue Yin, shaoyang and hand and foot Shao Yin are also used. Warming gallbladder and benefiting liver, stopping sweating and quenching thirst. Eliminate fatigue and insomnia, open cold and heat to block qi, strengthen bones and muscles, and stop hand and foot pain. For a long time, dampness and stagnation, nourishing yin and replenishing qi and replenishing the palace. "
13. "Ben Feng Jingyuan": "Ziziphus jujuba seeds are sweet and moist. Body fluid will converge after cooking, so it can treat insomnia, polydipsia and hyperhidrosis due to gallbladder deficiency. Life leads to deficiency heat, so treat the symptoms of gallbladder heat, good sleep, drowsiness and burnout; This medicine of foot jueyin shaoyang enters the spleen meridian of foot Taiyin. "
14. "deserved materia medica": "acid, flat. Entering the foot Jue Yin, starting from the blood division of Shaoyin Meridian. Collect the liquid of liver and spleen, nourish and replenish qi. Gather your heart and gallbladder to quench your thirst. Reinforce fire and produce stomach soil, strengthen bones and muscles and remove soreness. Take ginseng and poria cocos to treat night sweats. Take Rehmannia glutinosa, Schisandra chinensis and sweat. Combined with cinnabar and frankincense, it can treat insomnia due to gallbladder deficiency. Combined with Rehmannia glutinosa and japonica rice, it can cure shelling and insomnia. Stir-fried, cure gallbladder heat insomnia. It is used for relieving polydipsia and sweating. Stir-fried with vinegar, wake up the spleen. "
15. "Description of the nature of Leigong's processed drugs": "It tastes sour, flat, non-toxic, and enters the heart, spleen, liver and gallbladder. Main muscles and bones are sour and cold, night is restless, sweating is excessive and thirsty, calming the five internal organs and greatly nourishing the heart and spleen. Stir-fried peeled tips are used for research, and the living can cure lies. Evil is self-defense. "
16. Jian Yao: "It is flat, sweet and sour, and nontoxic. It can level the five internal organs and greatly tonify the heart and spleen. Therefore, blood does not belong to the spleen, and people who sleep uneasily should use it more. "
17. "medicinal use": "sweet and sour, into the heart, spleen, liver and gallbladder. Raw acid, benefiting the liver and gallbladder, calming the nerves and sweating; Cooked and sour, wake up and calm your nerves. "
18. "Gu Songyuan's Medical Mirror": "Stop convulsions and stop sweating, except for being upset and treating insomnia. Do not use excessive heat of liver, gallbladder and spleen, which will converge. "
19. Introduction to Medicine: "Semen Ziziphi Spinosae can relieve polydipsia, draw blood to move spleen to rest, tonify umbilical pain, soothe the heart and gallbladder, and remove spleen."
20. "Changsha Yaojie": "The ups and downs begin with less yin and less yang. It is best to have the courage to get rid of troubles and get sleepy. "
2 1. The newly revised "Materia Medica": "This classic treats insomnia with reality, but does not show benevolence. Today, using benevolence, nourishing the liver, strengthening the bones and muscles, and helping the yang are all the merits of Zizyphus jujuba. "
22. "Materia Medica is new": "Sweet and sour, sour, specially for the liver and gallbladder, sour, warm and fragrant, but also can wake up the spleen."
23. "Dictionary of Chinese Medicine": "Nourish the liver, calm the heart, soothe the nerves and stop sweating. Treat fatigue, insomnia, palpitation, polydipsia and hyperhidrosis. "
24. "Chinese Materia Medica": "Ningxin Anshen; Nourishing the liver; Sweating. The Lord is bored and sleepless; Panic and palpitation; Physical weakness, sweating and night sweats. "
Second, modern research.
1. Ingredients: mainly contains Ziziphus jujuba saponins A and B, nuciferine, rhamnose, protonase, norsoline, D- Hengzhou Linderae, etc. It also contains sugar, protein, volatile oil and organic acids.
2. Action: This product has sedative, analgesic, hypnotic, anticonvulsant and antiarrhythmic effects, and can cooperate with the central inhibitory effect of barbiturates. In addition, it has the functions of lowering body temperature, lowering blood pressure, reducing blood fat, resisting hypoxia, resisting tumor, inhibiting platelet aggregation, improving myocardial ischemia, enhancing immune function and so on.
3. Pharmacology:
1) Suanzaoren Decoction showed sedation and lethargy when given orally or intraperitoneally to rats. Ziziphus jujuba seeds can show the above effects no matter day or night, normal state or excited state caused by coffee. There is no difference in the sedative effect of raw jujube kernel and fried jujube kernel, but the sedative effect of raw jujube kernel is weak, and it will be ineffective if fried with oil for a long time. Some people think that its sedative active ingredients may be related to oil, while others think it is related to water-soluble parts.
2) It is proved by hot plate method that 5 g/kg Suanzaoren decoction has analgesic effect when injected into abdominal cavity of mice, and it has cooling effect on mice regardless of injection or oral administration, but it cannot antagonize experimental electric shock.
3) Semen Ziziphi Spinosae can cause continuous blood pressure drop and heart block. In hypertensive rats induced by kidney capsule, Ziziphus jujuba seed (20.30g/kg/ day) was given before or the next day after operation, which had obvious antihypertensive effect. The rats ate Ziziphus jujuba seeds, leaving a thin skin, and no sedation was found.
4) Semen Ziziphi Spinosae alone or in combination with Fructus Schisandrae Chinensis can improve the survival rate of scalded mice, prolong the survival time, delay the occurrence of burn shock in rats and prolong the survival time, and reduce the edema of burned parts in mice.