How long does it take to cook Radix Aconiti before use to effectively reduce toxicity?

It is the dry mother root of Aconitum. Ranunculaceae Location: Sichuan, Yunnan, Shaanxi, Hunan and other places. Digging from late June to early August, removing roots, fibrous roots and sediment, and drying in the sun. Used raw or made for later use. This medicine is pungent, bitter and hot. There is a big poison. Meridian of heart, liver, kidney and spleen.

Has the effects of expelling pathogenic wind and dampness, warming channels and relieving pain.

App application

1. Cold-dampness arthralgia. This product is pungent, hot, ascending, dispersing bitterness and dryness, and it is good at dispelling wind and removing dampness, warming meridians and dispersing cold, and has obvious analgesic effect. It is a good product for treating wind-cold-dampness arthralgia, especially wind-cold-dampness arthralgia. For those who can't bend or stretch due to cold and dampness, they are often combined with Herba Ephedrae, Radix Paeoniae and Radix Glycyrrhizae, such as Aconitum Decoction (Synopsis of the Golden Chamber). If it is combined with Aconitum kusnezoffii, Pheretima and Olibanum, it can be used to treat cold, dampness, stagnation of meridians, muscle and vein contracture pain of limbs, and unfavorable joint flexion and extension, such as Huoluo Dan (Heji Fang Ju).

2. Cold pain in the heart, cold hernia pain. This product has the effect of dispelling cold and relieving pain, so it is often used to treat heart cold pain caused by yin cold, and is often combined with halloysitum rubrum, dried ginger and pepper. , such as red aconite pill (synopsis of the golden chamber). For cold hernia, abdominal pain around umbilicus, cold hands and feet, etc., it is often decocted with honey, such as Dawu Decoction in synopsis of golden chamber.

3. Trauma, anesthesia and pain relief. The analgesic effect of this product can be used to treat traumatic injury, fracture, blood stasis and swelling and pain. It is often combined with native copper, earthworm and linden, such as Hui Sheng Xu Mingdan. In ancient prescriptions, this product is often used for anesthesia and pain relief, and is often combined with raw aconite root, konjac and turmeric for oral administration, such as "Orthopedic Anesthesia Prescription" ("Medical Zong Jin Jing"); Topical preparations, such as Mayaofang, are prepared from Rhizoma Arisaematis and Venenum Bufonis.

Usage and dosage: decocted,1.5 ~ 3g; It is advisable to fry first and then for a long time. External use, moderate amount.

Pay attention to the use of pregnant women; Not suitable for use with Fritillaria, Pinellia ternata, Bletilla striata, Ampelopsis, Trichosanthis Radix and Fructus Trichosanthis; Oral administration should generally be processed, and raw products should be used with caution; Soaking in wine and decocting is easy to poison, so use it with caution.

Ancient book abstracts

1. Shennong's Herbal Classic: "Treat apoplexy and evil wind, wash sweat, dispel cold and dampness, relieve cough and resist qi, and break the accumulation of cold and heat."

2. "Changsha Yaoxie": "Aconitum is warm and dry, and it is quick to benefit, and it is very effective in expelling cold and removing dampness. There are good deeds in various diseases such as beriberi, cold hernia, cold accumulation and chest pain. "

3. "Materia Medica Justice": "Aconitum is the main indication, warming meridians and dispelling cold. Although it is similar to aconite, it is not as effective as warming in the middle. And it aims to dispel the sound of external wind and external cold. "

Modern research

1. Chemical composition: This product contains many alkaloids, such as aconitine, aconitine, racemic noraconitine, ester aconitine, ester aconitine, 3- deoxyaconitine, aconitine, neoaconitine, chuanfuning, aconitine, sembunin A, B and aconitine.

2. Pharmacological effect: Radix Aconiti has obvious anti-inflammatory, analgesic and cardiotonic effects, but the increase of dose will cause arrhythmia and eventually cardiac inhibition; Aconitine can cause arrhythmia and increase blood pressure, and also enhance the toxic effect of echinacoside G on myocardium, which has obvious local anesthesia effect. Aconitum polysaccharide can significantly reduce normal blood sugar; Injection has inhibitory effect on gastric cancer cells.

3. Clinical study: Radix Aconiti has a good effect on arthritis, fibrositis, lumbar muscle strain, sciatica and calcaneal spur, and is used for mucosal surface anesthesia. In addition, 46 patients with gastric cancer after palliative surgery were given Aconitum injection 0.8mg/2ml, 1 ~ 2 times a day, and the effective rate was 80%. 22 cases of advanced primary liver cancer were treated, and the effective rate was 54.54% (Jinan Medicine,1983,4:1). 87 cases of scabies were decocted with 35g of Radix Aconiti and 35g of Radix Aconiti Kusnezoffii respectively, and all of them were cured (Fujian Traditional Chinese Medicine,1992,4:12); 18 intravenous injection of Compound Sansheng Injection (Radix Aconiti Lateralis Preparata, Radix Aconiti Lateralis Preparata, Rhizoma Arisaematis) 10ml in the treatment of chronic bronchitis, with marked effect in 18 cases and effective in 6 cases (Journal of Yunnan College of Traditional Chinese Medicine, 1986, 1:40). In addition, external use of Radix Aconiti is effective in treating chorea, myasthenia gravis, malaria, impotence in children and alopecia areata.

4. Adverse reactions: Improper use of aconite drugs can cause poisoning, with symptoms such as numbness of mouth, limbs and whole body, salivation, nausea, vomiting, diarrhea, dizziness, dry mouth, slow pulse, dyspnea, convulsion, unconsciousness, incontinence, blood pressure and body temperature drop, arrhythmia, ventricular premature beats and sinus arrest. A severely poisoned person may die of circulatory and respiratory failure and severe arrhythmia. Poisoning is mostly caused by mistake, overdose, unripe raw products, taking raw medicinal liquor and improper compatibility. The general treatment of poisoning is: early vomiting, catharsis, or high enema, rehydration and atropine injection. In severe cases, increase the dosage and shorten the interval, or take honeysuckle, licorice, mung bean, ginger, black bean, etc. at the same time. If frequent premature beats or paroxysmal ventricular tachycardia occur, lidocaine and procaine can be used. For patients with mild poisoning, 60g of mung bean, 6g of coptis chinensis, 0/5g of licorice, 0/5g of ginger and 0/5g of brown sugar can be decocted in water and then fed by nose or orally. You can also use honey 50 ~ 120 g and take it with cold boiled water; Arrhythmia can be decocted with Sophora flavescens 30g.

Kusnezoff monkshood

It is the dried root of kusnezoff monkshood. Ranunculaceae Location: Northeast China and North China. When the stems and leaves wither in autumn, remove fibrous roots and sediment and dry them. The performance, efficacy, application, usage, dosage and precautions are the same as those of Radix Aconiti, but the toxicity is stronger.