Contents 1 Pinyin 2 English Reference 3 National Essential Medicines 4 Overview 5 Efficacy and Indications of Huodan Pills 6 Pharmacopoeia Standards of Huodan Pills 6.1 Product Name 6.2 Prescription 6.3 Preparation Method 6.4 Properties 6.5 Identification 6.6 Inspection 6.7 Content Determination 6.7.1 Chromatographic conditions and system suitability test 6.7.2 Preparation of reference solution 6.7.3 Preparation of test solution 6.7.4 Determination method 6.8 Function and indication 6.9 Usage and dosage 6.10 Storage 6.11 Version 7 Huodan Pills Drug Instructions 7.1 Drug name 7.2 Drug Chinese Pinyin 7.3 Dosage form 7.4 Properties 7.5 Main ingredients of Huodan Pills 7.6 Functions and indications of Huodan Pills 7.7 Usage and dosage of Huodan Pills 7.8 Contraindications of Huodan Pills 7.9 Precautions 7.10 Interaction between Huodan Pills and other drugs Function 7.11 Remarks 8 References attached: 1 Huodan pills in ancient books* Other versions of drug instructions related to Huodan pills 1 Pinyin
huò dǎn wán 2 English reference
huodan pills [TCM] Pharmaceutical Terminology Approval Committee. Traditional Chinese Medicine Terminology (2004)]
huodan wan [Traditional Chinese Medicine Terminology Approval Committee. Traditional Chinese Medicine Terminology (2004)] 3 National Essential Medicines
and Huodan Pills Relevant national essential drug retail guideline price information serial number essential drug
Catalog serial number drug name dosage form specifications unit retail guide
guideline price category remarks 1065 93 Huodan Pills Water Pills 36g Bottle 7.2 Chinese Patent Medicine Part* 1066 93 Huodan Pills Water Pills 6g Bag 1.4 Chinese Patent Medicine Part 1067 93 Huodan Pills Water Pills 48g Bottle 9.4 Chinese Patent Medicine Part 1068 93 Huodan Pills Water Pills 60g Bottle 11.6 Chinese Patent Medicine Part
Note:
1. The dosage forms and specifications marked with “*” in the remarks column in the table are representative products.
2. The dosage form specifications marked with “△” in the remarks column of the table and other specifications of the same dosage form are provisional prices.
3. The dosage form specification indicates the usage and dosage in the remarks column. The prices of other specifications in this dosage form are based on the same usage and dosage and are calculated according to the "Drug Price Difference Rules".
4. The "Mi Wan" marked in the dosage form column in the table includes Xiao Mi Wan and Dami Wan. 4 Overview
Huodan Pill is a Chinese patent medicine whose main ingredients are patchouli leaves and pig gall powder[1]. It has the effects of aromaticizing turbidity, clearing away heat and clearing the orifices. It is used for nasal congestion, runny or turbid nasal discharge, and forehead headache caused by dampness and turbidity, gallbladder meridian stagnation and fire.
"The Pharmacopoeia of the People's Republic of China" (2010 edition) records the pharmacopoeial standards of Huodan Pills. 5 Effects and Indications of Huodan Pills
Huodan Pills have the effect of clearing away heat and resolving turbidity, and clearing the nose orifices. It is mainly used to treat nasal congestion and nasal congestion caused by wind-cold heat, gallbladder fire, and nasal congestion. [2].
Huodan Pills have the effects of aromatic and turbid, clearing away heat and clearing the orifices. It is used for nasal congestion, runny or turbid nasal discharge, and forehead headache caused by dampness and turbidity, gallbladder meridian stagnation and fire. 6 Pharmacopoeia standards for Huodan Wan 6.1 Product name
Huodan Wan
Huodan Wan 6.2 Prescription
4000g patchouli leaves, 315g pig gall powder 6.3 Preparation method
Take the patchouli leaves and crush them into fine powder, sieve; take the pig gall powder, heat it with ethanol and reflux it, filter it, recover the ethanol from the filtrate, dry it under reduced pressure, grind it into fine powder, and mix it with the patchouli leaves. Mix fine powder, pan-pellet with water, dry, coat with talcum powder and black iron oxide (1:1), dry, and get it. 6.4 Properties
This product is a black coated water pill. After removing the coating, it appears gray-brown to tan. It has a peculiar odor and a bitter taste. 6.5 Identification
(1) Take 4g of this product, grind it into coarse powder, place it in a stoppered Erlenmeyer flask, add 20ml of ether [3], shake, leave it overnight, filter, and evaporate the ether from the filtrate , add 1 ml of ethyl acetate to the residue to dissolve it, and use it as the test solution. Take another 1g of patchouli patchouli as reference medicinal material, add 20ml of ether, and prepare a reference medicinal material solution in the same way. Then take the Centaurea alcohol reference substance [3], add ethyl acetate to make a solution containing 1mg per 1ml, and use it as the reference substance solution.
According to the thin layer chromatography method (Appendix VI B of Pharmacopoeia 2010 edition), take 1~2ul each of the test solution and the reference solution, and 5ul of the control medicinal solution [3], and place them on the same silica gel G thin layer plate. Use petroleum ether (30~60℃) ethyl acetate-glacial acetic acid (95:5:0.2) as the developing agent, unfold, take out, dry, spray with 5% ferric chloride ethanol solution, and heat until the spots become clear. . In the chromatogram of the test product, spots of the same color appear at the positions corresponding to the chromatogram of the control medicinal material and the reference substance [3].
(2) [3] Take porodeoxycholic acid reference substance and chenodeoxycholic acid reference substance, add absolute ethanol to make a mixed solution containing 1mg per 1ml, as the reference solution. According to the thin layer chromatography (Appendix VI B of Pharmacopoeia 2010 Edition) test, take 2 μl each of the reference solution and the test solution under [Content Determination] [3], and place them on the same silica gel G thin layer plate respectively. Use the upper solution of n-hexane-ethyl acetate-methanol acetic acid (20:25:3:2) as the developing agent, unfold, take out, dry, spray with 10% sulfuric acid ethanol solution, and heat at 105°C until the spots are clearly colored. . In the chromatogram of the test product, spots of the same color appear at the positions corresponding to the chromatogram of the reference substance; when viewed under an ultraviolet light (365nm), fluorescent spots of the same color appear. 6.6 Inspection
It should comply with the relevant regulations under pills (Appendix I A of the 2010 edition of the Pharmacopoeia). 6.7 Content determination
Determine according to high performance liquid chromatography (Appendix VID of Pharmacopoeia 2010 edition). 6.7.1 Chromatographic conditions and system suitability test
Use octadecylsilane bonded silica gel as the filler; use acetonitrile 0.1% glacial acetic acid solution (50:50) as the mobile phase; evaporative light scattering detection device detection. The number of theoretical plates should not be less than 4000 based on the hyodeoxycholic acid peak. 6.7.2 Preparation of reference substance solution
Take appropriate amounts of porodeoxycholic acid reference substance and chenodeoxycholic acid reference substance, weigh them accurately, and add methanol to prepare a mixed solution containing 0.2mg per 1ml. That’s it. 6.7.3 Preparation of test solution
Take an appropriate amount of this product, grind it finely, take about 0.6g, weigh it accurately, put it in an Erlenmeyer flask, add 25ml of 10% sodium hydroxide solution, and shake well , seal tightly with a rubber stopper, saponify in an autoclave at 120°C for 5 hours, cool, transfer to a 50ml measuring flask, add water to wash the container several times and dilute to the mark, shake well, and filter. Precisely measure 25ml of the continued filtrate, adjust the pH value to 1 with hydrochloric acid, shake and extract with methylene chloride 4 times (40ml, 40ml, 30ml, 30ml). The extracts are all filtered through the same absorbent cotton layered with a small amount of anhydrous sodium sulfate. , wash anhydrous sodium sulfate and the filter with 20ml of methylene chloride in batches, merge the washing liquid into the filtrate, recover the methylene chloride until dry, add methanol to the residue to dissolve and transfer to a 10ml measuring bottle, add methanol to the mark, shake well, and filter After passing, take the continued filtrate to get it. 6.7.4 Determination method
Precisely absorb 10ul and 20ul of the reference solution and 10-20ul of the test solution, inject them into the liquid chromatograph, measure, and calculate using the external standard two-point logarithmic equation. That’s it.
Each 1g of this product contains pig bile powder, calculated as the total amount of hyodeoxycholic acid (C24H40O4) and chenodeoxycholic acid (C24H40O4), which shall not be less than 12.0mg. [3] 6.8 Functions and Indications
Aromatherapy to resolve turbidity, clear away heat and clear away the orifices. It is used for nasal congestion, runny or turbid nasal discharge, and forehead headache caused by dampness and turbidity, gallbladder meridian stagnation and fire. 6.9 Usage and dosage
Take orally. 3~6g at a time, 2 times a day. 6.10 Storage
Seal. 6.11 version
"Chinese Pharmacopoeia" 2010 Edition 7 Huodan Pills Drug Instructions 7.1 Drug Name
Huodan Pills 7.2 Drug Chinese Pinyin
Huodan Wan 7.3 Dosage Form
36g per bottle 7.4 Properties
Huodan Wan Pills are black coated water pills. After removing the coating, they appear grayish-brown to tan. They have a peculiar odor and a bitter taste. . 7.5 The main ingredients of Huodan Pills
Patchouli leaves and pig gall powder. 7.6 Functions and Indications of Huodan Pills
Aromatherapy to resolve turbidity, clear away heat and clear away the orifices. It is used for nasal congestion, runny or turbid nasal discharge, and forehead headache caused by dampness and turbidity, gallbladder meridian stagnation and fire. 7.7 Usage and dosage of Huodan Pills
Take orally. 3~6g at a time, 2 times a day. 7.8 Contraindications of Huodan Pills
It should not be used by those with spleen deficiency and clear and thin nasal discharge, and those who do not have the syndrome of gallbladder meridian depression and heat. 7.9 Precautions
1. Avoid tobacco, alcohol, spicy and fishy food.
2. It is not advisable to take nourishing Chinese medicine at the same time while taking the medicine.
3. People with serious chronic diseases such as high blood pressure, heart disease, liver disease, diabetes, and kidney disease should take it under the guidance of a physician.
4. Children, pregnant women, lactating women, the elderly and infirm, and those with spleen deficiency and loose stools should take it under the guidance of a physician.
5. If the symptoms are not relieved after taking the medicine for 3 days, you should go to the hospital for treatment.
6. It is forbidden for those who are allergic to Huodan Pills, and it should be used with caution by those with allergies.
7. It is forbidden to use Huodan Pills when their properties change.
8. Children must use it under adult supervision.
9. Please keep Huodan Pills out of reach of children.
10. If you are using other drugs, please consult your physician or pharmacist before using Huodan Pills. 7.10 Drug interactions
Drug interactions may occur if used together with other drugs. Please consult your physician or pharmacist for details.
7.11 Remarks