First of all, Nagato has a great advantage in intelligence. As we all know, the information about eye-rolling ability was not made public until Naruto fought Payne, and Shalingan's information from Kaleidoscope was recorded not only in some ancient books, but also in the families who fought against Uchibo, and it was leaked a lot in the tasks organized by Xiao. Nagato may not only know the sky photos of skunks and Harle, but also guess that skunks will attack Suksuke. Moreover, Nagato is not afraid of the masked man suspected of Uchihiro Madara, which also shows that he is not afraid of the ultimate power of the legendary Uchihiro clan. On the other hand, Uchiha Itachi not only didn't know Payne's six abilities, but maybe he didn't even know there was an ontological Nagato. So Uchiha Itachi is very backward in intelligence.
Of course, with Uchiha Itachi's strength not lost to Jiraiya and better intelligence IQ than Kakashi's in Jiraiya, it is certainly no problem to collect Payne's intelligence in the battle. But getting rid of Payne's Six Principles will inevitably consume a lot of energy and chakra.
Secondly, the level of round eyes is higher than that of kaleidoscope sharingan. Although Nagato can't develop the ability of round eyes, Uchiha Itachi, who didn't turn on the eternal kaleidoscope sharingan, can hardly use the pupil operation of the kaleidoscope sharingan at will, and the basic pupil force competition is obviously much stronger than that of the kaleidoscope sharingan.
Again, fighting ferrets is also a disadvantage. If the weasel knows the information of Nagato's ontology in the battle, if he wants to deal with Nagato with ten punches, he must solve Payne's six ways and find the position of Nagato's ontology. On the contrary, Nagato can not only restore chakra while the ferret is looking for his position, but also release the exploding star to seal the ferret directly. I'm afraid the ferret's attack alone may not be able to break through the earth-shattering star core. If the weasel doesn't know the intelligence of Dojo Gate, it's not to mention that it may not only reveal the intelligence of Ten Fists, but may even blow it up with a star seal without seeing Nagato's ontology. Therefore, although both skunks and Nagato have the ability to kill each other, Nagato has great advantages in attacking ground blasting stars on a large scale.
Finally, Nagato's endurance is much stronger than ferrets. Although both of them are physically ill, they are different. Nagato couldn't move because his leg was blown off by a detonator, and his ability to forcibly use the magical image of a psychic heretic lost many lives. In fact, its own state does not have much influence, otherwise it is impossible to control the consumption of eyes. But ferrets have an incurable disease, which greatly affects their physical condition. Therefore, the swordsman thinks that Nagato, whose life expectancy is shortened and his legs are disabled, can't move in the battle, but the ferret is likely to suffer from physical illness, which has a great influence in top-level battles.
To sum up, although both ferrets and Nagato have the ability to kill each other, judging from their living conditions, Nagato has a much higher chance of winning than ferrets. Of course, if it is in a filthy state of metempsychosis, Nagato, which lacks mobility without bijuu and chakra, may be easily solved by ferrets. what do you think?