2 national essential drugs and Guipi mixture related national essential drugs retail guidance price information
Essential drug serial number
DirectoryNo. Drug name, dosage form and specification Retail unit refers to
Remarks on price category 424 35 Guipi Mixture 10ml branch 1.6 Chinese patent medicine part * 425 35 Guipi Mixture 100ml bottle 13.5 Chinese patent medicine part Note:
1. The dosage form specifications marked with "*" in the remarks column in the table are representative products.
2. Specifications of dosage forms with "△" in the remarks column in the table, and other specifications of the same dosage form are tentative prices.
3. The dosage form specifications are indicated in the remarks column. The prices of other specifications in this dosage form are based on the same usage and dosage, and are calculated according to the drug price comparison rules.
4. The "honey pills" marked in the column of dosage form in the form include small honey pills and big honey pills.
3 Guipi Mixture Pharmacopoeia Standard 3. 1 Name Guipi Mixture
Gui pi he Ji
3.2 Prescription of Radix Codonopsis 68g, fried atractylodes 136g, Radix Astragali preparata 68g, Radix Glycyrrhizae preparata 34g, Poria 136g, Radix Polygalae preparata 136g, Semen Ziziphi Spinosae 68g, Arillus longan 136g, Radix Angelicae Sinensis 136g, and Radix Aucklandiae.
3.3 Prepare the above twelve medicinal materials, and distill and extract the volatile oil from Atractylodes macrocephala, Radix Aucklandiae and Radix Angelicae Sinensis respectively; Percolating the residue of Radix Angelicae Sinensis with 50% ethanol as solvent, collecting percolate, and recovering ethanol; Decocting Rhizoma Atractylodis Macrocephalae, Radix Aucklandiae residue and other nine Radix Codonopsis in water for three times, the first time is 2 hours, the second time is 65438 0.5 hours, and the third time is 65438 0 hours, mixing decoctions, filtering, concentrating the filtrate to a proper amount, mixing with the percolate, standing, filtering, concentrating the filtrate to about 65438±0000ml, adding 3g sodium benzoate, cooling, and cooling.
3.4 Characteristics This product is reddish brown to brownish black liquid; The smell is fragrant, and the taste is slightly sweet and bitter.
3.5 Identification (1) Take the test solution under 【 Content Determination 】 as the test solution. In addition, take 0.5g of Codonopsis pilosula reference medicinal material, add 50ml of methanol, heat and reflux for 2h, filter, evaporate the filtrate to dryness, add 65438 00 ml of water to dissolve the residue, shake and extract with water saturated n-butanol for three times, 40ml each time, combine n-butanol solutions, wash with 40ml of ammonia test solution, evaporate the n-butanol solution to dryness, and add 65438 00 ml of methanol to dissolve the residue. As a control, the medicinal solution was tested by thin-layer chromatography (appendix ⅵ b of Pharmacopoeia I, 20 10), and the above two solutions 1μl were absorbed, respectively, on the same silica gel G thin-layer plate, with n-butanol-ethanol-water (7: 2: 1) as the developing agent, developed, taken out, dried and sprayed. In the chromatogram of the test sample, the spots with the same color appear at the positions corresponding to the chromatogram of the control medicinal materials.
(2) Take 20ml of this product, shake and extract it with water-saturated n-butanol for 2 times, 30ml each time, combine the n-butanol extractive solutions, evaporate to dryness, add 20 ml of anhydrous ethanol solution of hydrochloric acid (10 → 100) to the residue, heat and reflux for 30 minutes, cool, filter, add 30ml of water to the filtrate, shake and extract it with chloroform for 2 times. In addition, take polygala tenuifolia 1g, and prepare the control medicinal solution by the same method from "adding 20 ml of hydrochloric acid absolute ethanol solution (10 →100)". According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia Part I, 20 10), absorb 5μl of the above two solutions, respectively spot them on the same silica gel G thin-layer plate, develop with n-hexane-chloroform-acetone (0.2: 8: 3) as the developing agent, take them out, dry them, spray them with 2% vanillin sulfuric acid solution, and spray them on/KLOC-. In the chromatogram of the test sample, the spots with the same color appear at the positions corresponding to the chromatogram of the control medicinal materials.
(3) Take 20ml of this product, shake it well, extract it with ether twice, 25ml each time, combine the ether extracts, evaporate, and dissolve the residue with 1ml methanol as the test solution. In addition, 65438 0 g of Angelica sinensis was taken, 65438±00ml of methanol was added, and ultrasound was performed for 65438±05min, and the filtrate was used as the control medicinal solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia Part I, 20 10), respectively absorb the above two solutions 10μl on the same silica gel G thin-layer plate, use cyclohexane-ethyl acetate (9: 1) as the developing agent, unfold, take out, dry and examine under ultraviolet light (365nm). In the chromatogram of the test sample, fluorescent spots with the same color appear at the positions corresponding to the chromatogram of the control medicinal materials.
(4) Take this product and test it according to the method under 【 Content Determination 】. The chromatographic peak corresponding to the retention time of the chromatographic peak of astragaloside IV reference substance should appear in the chromatographic sample.
3.6 Check that the relative density of 3.6. 1 shall not be lower than 1.08 (Appendix VII A of Pharmacopoeia 20 10).
3.6.2 The pH value should be 3.5 ~ 5.5 (Appendix VII G of Pharmacopoeia 20 10).
3.6.3 Others shall comply with relevant regulations under mixture (Appendix I J of Pharmacopoeia I, 20 10 edition).
3.7 The content was determined by high performance liquid chromatography (Appendix ⅵ D of China Pharmacopoeia I, 20 10).
3.7. 1 chromatographic conditions and system applicability test, using octadecylsilane bonded silica gel as filler; Acetonitrile-water (32: 68) was used as the mobile phase; Detected by evaporative light scattering detector. According to the peak calculation of astragaloside IV, the theoretical plate number should be not less than 5000.
3.7.2 Preparation of reference solution Take appropriate amount of astragaloside IV reference substance, weigh it accurately, and add methanol to make a solution containing 0.2mg per kloc-0/ml.
3.7.3 Preparation of test solution Accurately measure 25ml of this product, put it in a separatory funnel, shake and extract it with water-saturated n-butanol for 4 times (gently shake for the first time), 25ml each time, combine the n-butanol extract, wash it with 25ml ammonia test solution for 3 times, evaporate the n-butanol solution, dissolve the residue with methanol, transfer it to a 5ml volumetric flask, add methanol to the scale, shake well, filter and take a continuous filtrate.
3.7.4 Determination Method Accurately absorb 10μl and 20μl of control solution and 20μl of test solution, inject them into liquid chromatograph, determine them, and calculate them with two-point logarithmic equation of external standard method.
Every 65438±0ml of this product contains Radix Astragali Preparata, calculated by astragaloside IV (C4 1H68O 14), which shall not be less than 65438±05μg g. ..
3.8 Functional indications: invigorating qi and spleen, nourishing blood and calming the nerves. Used for deficiency of both heart and spleen, shortness of breath, palpitation, insomnia, dreaminess, dizziness, weakness of limbs, anorexia, metrorrhagia and hematochezia.
3.9 Oral administration and dosage. 10 ~ 20ml once, three times a day; Shake well when using.
3. 10 specification (1) per box 10ml? (2) per bottle 100ml? (3) each bottle120ml
3. 1 1 Store in a cool place and keep it sealed.
3. The second supplement to the 20 10 edition of People's Republic of China (PRC) Pharmacopoeia.
4. Standard issued by the Ministry of Traditional Chinese Medicine 4. 1 Guipi Mixture with Pinyin Name
4.2 standard number WS3B 152293
4.3 Prescription Codonopsis pilosula 68g Atractylodis Macrocephala (stir-fried) 136g Radix Astragali (honey-fried) 68g Radix Glycyrrhizae (honey-fried) 34g Poria 136g Radix Polygalae (prepared) 136g Semen Ziziphi Spinosae 68g Polyporus 136g Radix Angelicae Sinensis 136g Radix Aucklandiae 34g Jujube.
4.4 Prepare the above twelve medicinal materials, and distill Atractylodes macrocephala, Mudexiang and Angelica to extract volatile oil respectively; The residue of Angelica sinensis was percolated according to the percolation method under fluid extract and extract (Appendix 17), and the solvent was 50% ethanol. Recovering ethanol from leachate; Decocting Atractylodis Rhizoma, Radix Aucklandiae residue and other nine kinds of Radix Codonopsis in water for three times, mixing decoctions, filtering, concentrating the filtrate to an appropriate amount, mixing with percolate, standing, filtering, concentrating to about 65,438 0,000 ml, adding an appropriate amount of preservative, cooling, adding volatile oil, adding water to 65,438 0,000 ml, and stirring.
4.5 Characteristics This product is a brown-black clear liquid; The smell is fragrant, and the taste is slightly sweet and bitter.
4.6 Check that the relative density should not be less than 1.08 (Appendix 34). Others shall comply with the relevant regulations under the mixture (Appendix 65438+ Page 5).
4.7 Functions and indications: invigorating qi and spleen, nourishing blood and calming the nerves. It can be used for deficiency of both heart and spleen, shortness of breath, dreaminess in palpitation and insomnia, dizziness, weakness of limbs, anorexia, metrorrhagia and hematochezia.
4.8 Administration and dosage: orally, 10 ~ 20ml once. 3 times a day; Shake well when using.
4.9 Store in a cool and airtight place.
5. Instructions for Guipi Mixture 5. 1 Type of traditional Chinese medicine
5.2 Drug Name Guipi Mixture
5.3 Chinese Pinyin for Drugs and Spleen-Replenishing Agents
5.4 Ingredients: Radix Codonopsis, fried atractylodes, Radix Astragali Preparata, Radix Glycyrrhizae Preparata, Poria, Cortex et Radix Polygalae preparata, Semen Ziziphi Spinosae preparata, Arillus Longan, Radix Angelicae Sinensis, Radix Aucklandiae, Fructus Jujubae (removed) and Rhizoma Zingiberis Recens.
5.5 Character Guipi Decoction is reddish brown to brownish black liquid; The smell is fragrant, and the taste is slightly sweet and bitter.
5.6 Guipi Mixture has the functions of invigorating qi and spleen, nourishing blood and calming the nerves. Used for deficiency of both heart and spleen, shortness of breath, palpitation, insomnia, dreaminess, dizziness, weakness of limbs, and loss of appetite.
5.7 Usage and dosage of Guipi mixture: 10 ~ 20ml once. 3 times a day; Shake well when using.
5.8 Precautions 1. Avoid greasy food.
2. Exogenous or excess heat should not be taken.
3. Guipi decoction should be taken before meals.
4. Take according to usage and dosage. Children, pregnant women, patients with hypertension and diabetes should take it under the guidance of a doctor.
5. If the symptoms do not improve obviously after taking the medicine for two weeks, or the symptoms get worse, you should stop taking the medicine immediately and go to the hospital.
6. It is forbidden for those who are allergic to Guipi Decoction, and should be used with caution for those who are allergic.
7. When the nature of Guipi Decoction changes, it is forbidden to use Guipi Decoction.
8. Children must use it under the supervision of adults.
9. Please put Guipi decoction out of the reach of children.
10. If you are using other drugs, please consult a doctor or pharmacist before using Guipi Decoction.
5.9 Drug Interaction If used together with other drugs, drug interaction may occur. Please consult a doctor or pharmacist for details.
5. 10 Remarks: Please read the instructions carefully and use them according to the instructions or purchase them under the guidance of pharmacists.
Zhang Yitong, a miscellaneous book of ancient books and ghosts: [Volume 7] Lintong. Small intestine occlusion. Ginseng and licorice are added into Wuling powder. Next spring, Zetang. The most mixed. The elderly with qi deficiency have heavy stranguria. Buzhong Yiqi plus Akebia stem and Alisma orientalis. Yisheng ...
"Treatment of Syndrome": [Volume 2] To treat sweating, it is necessary to have deficiency of both qi and blood, and spontaneous sweating will not subside. Buzhong Yiqi decoction plus Chuanfu, or Guipi decoction. If the stool is dry, spontaneous sweating and fever persists, it belongs to yin blood. Liuwei Dihuang Decoction can dredge the pulse. ...
Zhang Yitong: [Volume 9 Miscellaneous] Sweater. Yin and Yang are not harmonious. Half exterior and half interior syndrome. Xiaochaihu, Xiaoyao powder. So are all mixtures. It is related to wind evil and phlegm-dampness. There are also many. Sweating like a pig. Or for the sake of ...
Gynecological Jade Ruler: [Volume V] Prescription for metrorrhagia and metrorrhagia: Qin Huanglian and Huang Baishan tourniquet (one yuan each). The mixture of Siwu decoction and Huanglian Jiedu decoction can also be used. Prepare gold powder to treat bloody collapse. Cyperus rotundus (four Liang) returns to the tail (two Liang Qian) ...
Zhang Yitong: [Volume IV] Subgastric Cough.