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traditional Chinese medicine
Compatibility taboo refers to the fact that some drugs are banned or unsuitable for use in compound prescription. As early as "Ben Jing? In the preface, there is a sentence in the "Seven Emotions": "Don't use opposites and opposites", which is also the basic basis for later compatibility taboos. But the consequences of opposition are different. Oppositional compatibility only reduces some properties of drugs, and some drugs can reduce or eliminate their side effects by reducing some properties, which is more beneficial to diseases. It is also an available compatibility relationship, so it is not an absolute taboo. On the contrary, compatibility may endanger the health and even life of patients. So in principle, it is forbidden to use the opposite drugs together. When Han Baosheng of Shu revised Shu Materia Medica after the Five Dynasties, he first counted the number of seven emotions and mentioned that "there are 78 kinds of people who are afraid of each other, 60 kinds of evil people and 18 kinds of opponents". The so-called "eighteen objections" in later generations actually originated from this. The meaning of mutual fear in the "seven emotions" of traditional Chinese medicine has been mentioned in the previous section. However, since the Song Dynasty, some medical books have been confused in the use of names of fear, evil and anti-fear, which is different from the original meaning of "fear" in "Seven Emotions" in Benjing. As a taboo of compatibility, Nineteen Fears was put forward in this situation. At present, there are mainly "eighteen evils" and "nineteen fears" in the medical field.
Eighteen opposites: licorice, spurge, seaweed and Daphne genkwa; Bulbus Fritillariae Cirrhosae, Fructus Trichosanthis, Rhizoma Pinelliae, Radix Ampelopsis and Rhizoma Bletillae; Veratrum nigrum, Radix Adenophorae, Radix Salviae Miltiorrhizae, Radix Scrophulariae, Radix Sophorae Flavescentis, Asari and Radix Paeoniae.
Attachment: eighteen anti-songs:
Materia Medica clearly states eighteen opposites, half attacking shellfish and attacking Ukraine.
Algae halberd is against grass, and five ginseng herbs are against veratrum.
Nineteen fears: sulfur is afraid of mirabilite, mercury is afraid of arsenic, stellera chamaejasme is afraid of lithargyrum, croton is afraid of Petunia, clove is afraid of turmeric, Sichuan aconite and kusnezoff monkshood are afraid of rhinoceros horn, tooth nitrate is afraid of triangular prism, official Guiwei is afraid of lithopone, and ginseng is afraid of trogopterori.
Attachment: nineteen fears of songs:
Sulfur is the essence of fire, and when you see it, it fights with nitrate.
Mercury can't meet arsenic, and wolfsbane is most afraid of monks.
Croton is the strongest and not suitable for Petunia.
Clove and turmeric can't be seen, and saltpeter and thorns can't be combined.
Kusnezoff monkshood is not suitable for rhinoceros, and ginseng is most afraid of trogopterori.
Guan Gui is good at regulating qi, but he deceives others when he meets stone grease.
Too often, the repair depends on the order, and the guns [zhk8] are closely related to each other.
The number of eighteen evils and nineteen fears listed above is based on the popular tunes and prescriptions since Jin and Yuan Dynasties, so it is followed by most doctors, but it is not the only number of anti-drugs and fears in herbal literature. Generally, eighteen opposites exceed this number, and nineteen may be less than this number.
For eighteen opposites and nineteen fears as compatibility taboos, doctors in past dynasties followed the letter; There are many opponents. Some people think that eighteen evils and nineteen fears are not absolute taboos; Some scholars even think that the combination of opposite drugs can complement each other and have a powerful effect. For chronic diseases, as long as they are used properly, they can often achieve miraculous results.
In recent years, some pharmacological experiments have been carried out on the compatibility of eighteen evils and nineteen fears. However, there are many problems involved in eighteen evils and nineteen fears, and the experimental results are quite different because of the differences in experimental conditions and methods of researchers. Some people use toxicity tests to produce contradictory or negative results. Early research results tend to be completely negative; In recent years, the observation has gradually deepened, and the voice of "not easy to deny" is getting higher and higher. In addition, experiments have proved that the toxic and side effects of eighteen evils and nineteen evils are related to the absolute and relative doses of drugs.
Generally speaking, the drugs of eighteen evils and nineteen fears need further observation and research. If you don't have enough foundation and application experience, don't use them together.
Western medicine:
Serial number drug 1 drug 2 compatibility results
1 penicillin ofloxacin turbidity
2 penicillin aminophylline penicillin inactivation, the curative effect decreased.
3 Penicillin sodium bicarbonate inactivates penicillin and the efficiency decreases.
Penicillin and glucose decompose quickly.
5 Penicillin alamin has a chemical reaction.
Penicillin reacts with neofolin.
7 penicillin gentamicin gentamicin inactivation is invalid.
8. Inactivation of penicillin amikacin and decline of amikacin.
9 Penicillin macrolides have incompatibility.
10 penicillin vitamin c penicillin decomposes quickly.
1 1 penicillin hydrocortisone penicillin is invalid.
12 penicillin Huang Cen injection precipitation.
13 penicillin Huanglian injection precipitation
14 ampicillin-sulbactam 10%GS or 5%GNS is unqualified, and room temperature 1h is unqualified.
15 ampicillin-sulbactam 5% sodium bicarbonate is invalid, and its appearance is milky white.
16 azlocillin vitamin B6 precipitation
17 azlocillin aminobenzoic acid precipitation
18 the ph value of azlocillin vitamin c changes more than 0.2, so it is better to mix less.
19 the pH value of azlocillin and amikacin changed more than 0.2, which should be due to poor compatibility.
The pH change of 20 azlocillin micronomicin is greater than 0.2, so it is advisable to mix less.
The pH value of 2 1 azlocillin gentamicin changed more than 0.2, which should be due to poor compatibility.
The change of pH value of 22- azlocillin cefazolin is greater than 0.2, which should be due to poor compatibility.
23 the pH value of azlocillin and dexamethasone changes more than 0.2, so it is advisable to mix them less.
24 The pH value of azlocillin inosine changes more than 0.2, so it is advisable to mix less.
25 Azlocillin Nojia precipitate
26 ampicillin sodium 0.5% metronidazole discoloration, precipitation
The precipitation and decomposition of ampicillin sodium aminophylline failed.
Ampicillin sodium and gentamicin are incompatible.
29.5% or 10% GS solution was ineffective for ampicillin sodium.
30 ampicillin sodium aminophylline precipitation decomposition failed.
3 1 carbenicillin sodium and 0.5% metronidazole reduced the efficacy.
32 carbenicillin sodium and micronomicin reduce the curative effect.
33 turbidity of mezlocillin sodium ciprofloxacin
34 turbidity of mezlocillin sodium and diammonium glycyrrhizinate
35 Amoxicillin sodium 5% or 10%GS discolors and reduces efficacy (proportional to temperature and time).
36 Amoxicillin Sodium 5%GNS as above.
The precipitation and decomposition of amoxicillin sodium aminophylline failed.
38. Cefotaxime sodium bicarbonate red compatibility taboo, mutual toxicity.
39 Cefotaxime sodium metronidazole 4 hours later, there were a few bubbles at the bottom of the bottle, and the color of the solution became darker.
40 cefotaxime sodium fluconazole delayed turbidity and discoloration.
4 1 cefotaxime sodium 5%GS white turbidity
42 ceftriaxone sodium compound sodium chloride milky white turbidity
43. The PH value of ceftriaxone sodium aminophylline changes and decreases.
Ceftriaxone sodium and fluconazole precipitation
Ceftriaxone sodium vancomycin precipitation
46. Ceftriaxone sodium, zedoary turmeric oil and glucose solution turn brown.
47 Ceftriaxone Sodium Aminoglycosides Turbidity
48 ceftriaxone sodium furosemide turbidity
49 turbidity of ceftriaxone sodium calcium gluconate
50 ceftazidime vitamin C content decreased.
5 1 ceftazidime fluconazole precipitation
52 ceftazidime 5% sodium bicarbonate reduces the curative effect.
53 cefradine hemostasis turbidity
54 cefradine zedoary turmeric oil glucose solution turns brown.
Decomposition of 55 cefradine aminophylline failed.
56. Cefazolin sodium sulbactam sodium pefloxacin white turbidity.
57 Cefpiram nabafloxacin is a white turbid precipitate.
58. Cefuroxime sodium aminoglycosides are physically and chemically incompatible.
59 cefoperazone sodium 5% sodium bicarbonate changed color and precipitated after 4 hours.
60 cefoperazone sodium and 0.5% metronidazole changed color and precipitated after 4 hours.
Discoloration and precipitation of 6 1 cefoperazone sodium perphenazine
Discoloration and precipitation of cefoperazone sodium and pethidine
63 cefoperazone sodium ciprofloxacin milky white turbidity
Cefoperazone sodium and cimetidine are turbid.
Discoloration and precipitation of 65 cefoperazone labetalol sodium
66. Sedimentation or reduction of aminoglycosides in cefoperazone sodium
67 Cefoperazone Sodium Hemostatic Turbidity
68 cefoperazone sodium norfloxacin milky white turbidity
69 Turbidity of Cefoperazone Sodium Calcium Gluconate
70 cefoperazone sodium ofloxacin white turbidity
7 1 cefoperazone sodium zedoary turmeric oil glucose solution turns brown.
72 cefoperazone sodium pefloxacin is a white turbid precipitate.
73. Sedimentation or decrement of cefoperazone sodium and sulbactam sodium and amikacin.
74. Cefoperazone sodium and sulbactam sodium are white and turbid.
75 amikacin total intravenous nutrient solution 1h showed demulsification of fat emulsion.
76 Amikacin platinum compound has increased nephrotoxicity.
Amikacin and lincomycin increase drug toxicity.
Amikacin amphotericin B increases nephrotoxicity.
Amikacin polymyxin increases nephrotoxicity.
80 amikacin furosemide increased toxicity.
8 1 amikacin Qingkailing turbidity
The toxicity of dextran of micronomicin 82 is enhanced.
83. The ototoxicity of minocycline, a powerful diuretic, increased.
84 netilmicin vitamin C reduced this effect.
Increased nephrotoxicity of 85 netilmicin and furosemide
86 ciprofloxacin penicillin G sodium formed a large number of precipitates within 65438±0h hours.
87 ciprofloxacin aminophylline precipitation
88 ciprofloxacin lincomycin precipitation
89 incompatibility between ciprofloxacin and heparin
90 ciprofloxacin ampicillin sodium milky white flocculent precipitation
9 1 ciprofloxacin compound Danshen immediately produced yellow precipitate.
92 ciprofloxacin erythromycin precipitation
Ciprofloxacin furosemide turbidity
94 ciprofloxacin and fosfomycin were opalescent and turbid.
95 ciprofloxacin sodium bicarbonate white turbidity
Discoloration and precipitation of 96 ciprofloxacin amikacin
97 norfloxacin ampicillin precipitate
98 Norfloxacin Oxacillin Precipitation
99 Pefloxacin penicillin G sodium precipitated in 1h, which reduced the effect.
100 pefloxacin compound salvia miltiorrhiza turbidity
10 1 fleroxacin aminophylline serious adverse reaction (which reaction data is not specified)
102 ofloxacin compound salvia miltiorrhiza is fuzzy caked into blocks.
103 turbidity of ofloxacin and furosemide
104 the pH value of levofloxacin increased, and the microstructure spectrum of vitamin c changed.
105 levofloxacin adenosine triphosphate changes obviously, so it is incompatible.
106 levofloxacin compound Danshen is opaque
107 turbidity of levofloxacin furosemide
108 increased the toxicity of micronomicin dextran.
109 minocycline diuretic increased ototoxicity.
1 10 minocycline Qingkailing turbidity
1 165438+
1 12 turbidity of fosfomycin compound salvia miltiorrhiza
1 13 fosfomycin calcium gluconate precipitation
1 14 erythromycin vitamin c reduces the curative effect.
1 15 erythromycin physiological saline precipitation, crystallization, precipitation.
1 16 antagonism and cross-resistance of erythromycin and lincomycin
1 17 The insoluble substance of epirubicin glucoside or compound sodium chloride floats in red.
1 18 5% epirubicin or 10%GS solution decreased the curative effect.
1 19 epirubicin 17- amino acid is invalid.
120 epirubicin and metronidazole decreased the curative effect.
12 1 acyclovir 5% or 10%GS solution changes color.
122 ACV 5%GNS solution becomes discolored.
123 white flocculent precipitation of potassium magnesium radon in acyclovir gate
124 discoloration of acyclovir low molecular dextran
125 fluconazole amphotericin b delayed turbid precipitation.
126 fluconazole and ampicillin sodium delayed turbidity and precipitation.
127 fluconazole calcium gluconate delayed turbid precipitation.
128 fluconazole and cefuroxime sodium precipitation
129 fluconazole amber chloramphenicol gas generator
130 fluconazole clindamycin precipitation
13 1 fluconazole erythromycin precipitation
132 fluconazole and piperacillin sodium as colloid.
133 delayed precipitation of fluconazole and furosemide
134 fluconazole diazepam precipitation
135 Shuanghuanglian powder injection amikacin precipitation
136 Shuanghuanglian powder injection ampicillin color deepened.
137 turbidity of tobramycin for Shuanghuanglian powder injection
138 Shuanghuanglian powder injection contains bleomycin turbidity.
139 turbidity of azithromycin for Shuanghuanglian powder injection
140 turbidity of Shuanghuanglian powder injection
14 1 sodium dehydroandrographolide succinate
142 yanhuning vitamin B6 jelly
143 Yanhuning fleroxacin is white and turbid.
144 chuanhuning baimycin is milky white and turbid.
145 chuanhuning vitamin B6 is milky white and turbid.
146 Ning Chuan amikacin precipitation
147 chuanhuning ofloxacin precipitation
148 chuanhuning sisomicin precipitation
149 Ning Chuan tobramycin precipitation
150 Ning Chuan gentamicin turbidity.
15 1 Ning Chuan ciprofloxacin precipitation
152 penehyclidine pefloxacin precipitation
153 chuanhuning mucosolvan is white and turbid.
154 turbidity of potassium dehydroandrographolide gluconate
155 turbidity of compound Danshen potassium chloride
156 turbidity of compound Danshen injection
157 turbidity of compound Danshen azithromycin
158 compound salvia miltiorrhiza vitamin B6 turbidity
159 compound salvia miltiorrhiza anticancer drug promotes the metastasis of malignant tumor.
160 compound salvia miltiorrhiza cytochrome c becomes dark, turbid and ineffective.
16 1 compound Danshen pefloxacin turbidity
162 eggplant turbidity
163 opaque
164 opal furosemide turbidity
165 Oubei Compound Danshen Turbid
166 opal 5- fluorouracil turbidity
167 lactoinosine turbidity
168 turbidity of furosemide lomefloxacin
169 furosemide milrinone precipitate
170 furosemide metronidazole precipitation
17 1 inosine mucosolvan turbidity
172 5% nabafloxacin bicarbonate is white and turbid.
173 5% sodium bicarbonate cimetidine turbidity
174 dexamethasone, phenamine, white turbidity
175 dexamethasone propafenone turbidity
176 vitamin K 1 vitamin c vitamin K 1 unqualified.
177 vitamin K 1 grey goose down yellow turbidity
Turbidity of 178 losec compound amino acids
179 FDP alkaline solution or calcium salt may be physically and chemically incompatible.
180 urokinase alkaline drug precipitation
18 1 morphine chlorpromazine respiratory depression
Antagonism of 182 metoclopramide atropine
183 lincomycin sulfadiazine sodium precipitation
184 adrenaline digitalis is easy to be poisoned.
185 calcium gluconate digitalis increased toxicity.
186 precipitation of aminophylline acids.
187 gentamicin heparin sodium precipitation
188 bupivacaine alkaline drug precipitation
189 incompatibility of Tylenol solution containing sodium lactate.
190 turbidity of astragalus vitamin B6