2 English reference Da Zhu [2 1 Century Bilingual Dictionary of Science and Technology]
Daqufeng Decoction [Xiangya Medical Dictionary]
Da feng feng Zhu wan [Chinese medicine terminology Committee] Terminology of Traditional Chinese Medicine (2004)]
The third volume of Treatise on Febrile Diseases records Dading Fengzhu, which consists of two black-bone chickens, donkey-hide gelatin 9g, raw white peony root 18g, raw tortoise plastron 12g, dried rehmannia root 18g, fructus Cannabis 6g, Schisandra chinensis 6g, raw oyster 12g and Ophiopogon japonicus/kloc. Indications are yin deficiency and wind-driven syndrome. This prescription is a commonly used representative prescription for treating yin deficiency and wind-moving syndrome in the late stage of epidemic febrile disease. Modern medicine is often used to treat convulsion, zinc deficiency, acute renal failure, tongue atrophy after radiotherapy, etc. [ 1]
Dading Zhu Feng is the name of this prescription, which comes from the second volume of Treatise on Epidemic Febrile Diseases [2].
This prescription has a certain therapeutic effect on "weak pulse and always want to get rid of it" in the late stage of epidemic febrile disease by regulating nerve, endocrine, metabolism, immunity and cardiovascular functions. From the point of view of modern medicine, it should have a certain therapeutic effect on various severe infectious diseases complicated with brain dysfunction, heart and circulation dysfunction, especially dehydration and electrolyte disorder, and various shocks. However, all kinds of fever are serious in the later period, which requires the combination of modern medical methods, especially cardiotonic, anti-shock, correcting dehydration acidosis, correcting electrolyte disorder and supplementing heat. This prescription should also be combined with effective antibiotics and antiviral drugs. [3]
4. 2 black-bone chickens, 9 grams of colla corii asini, 8 grams of radix paeoniae alba 12, tortoise plastron 18, radix rehmanniae 18, 6 grams of fructus cannabis, 6 grams of Schisandra chinensis, 6 grams of oyster 12, 0/8 grams of Ophiopogon japonicus, and turtle shell.
Radix Paeoniae Alba 18g, Colla Corii Asini 9g, Carapax et Plastrum Testudinis 12g, Radix Rehmanniae 18g, Fructus Cannabis 6g, Fructus Schisandrae 6g, Oyster 12g, Radix Ophiopogonis (Lian Xin) 18g, Radix Glycyrrhizae Preparata 12g.
Radix Paeoniae Alba, Radix Rehmanniae and Radix Ophiopogonis (Lian Xin) in 6 yuan, Colla Corii Asini in San Qian, Carapax et Plastrum Testudinis in 4 yuan, Radix Glycyrrhizae Preparata and Carapax Trionycis in, Fructus Cannabis and Fructus Schisandrae Chinensis in 2 yuan, and two raw black-bone chickens [2].
Six dollars for raw white peony root, four dollars for raw donkey-hide gelatin San Qian, four dollars for raw tortoise plastron, six dollars for raw rehmannia root, two dollars for hemp seed, two dollars for Schisandra fruit, four dollars for raw oysters, six dollars for Ophiopogon japonicus (Lian Xin), four dollars for roasted licorice, two dollars for black-bone chicken (raw) and four dollars for turtle shell (raw) [5].
Usage: Take eight glasses of water, boil three cups, remove me, the donkey-hide gelatin melts, then go to black-bone chicken, stir and take it, and take it three times. [ 1]
Decoct with water to remove residue, add black-bone chicken, and take it in three times [2].
Decoct that above raw materials in wat, removing impurities, adding colla Corii Asini and Mel, mix, and taking silky fowl for 3 times, daily 1 dose. [4]
Eight cups of water, three cups of boiling water, go to my place, re-enter the black-bone chicken, mix it up and take it three times [5].
6. Dading Zhu Feng is mainly used to treat three aspects of Treatise on Febrile Diseases, which has the effects of nourishing yin and calming wind, nourishing yin and promoting fluid production, and softening the liver and calming wind. Indications are yin deficiency and wind-driven syndrome. In the late stage of epidemic febrile disease, the symptoms are mental fatigue, carbuncle swelling, weak pulse, less red tongue coating, and sometimes a tendency to take off. [ 1]
The two large wind beads in Syndrome Differentiation of Epidemic Febrile Diseases have the function of nourishing body fluid and calming wind. If the heat pathogen is treated for a long time, it will burn the true yin, or it will cause carbuncle, weak pulse, red tongue and little fur due to the misuse of sweat, diarrhea, heavy vaginal fluid and fatigue. It is often used in the late stage of Japanese encephalitis, and tremor paralysis belongs to the syndrome of yin deficiency and wind movement [2].
Indications: the syndrome of hyperactivity of liver wind due to sudden blindness tends to be due to yin deficiency [6].
Fang Jie Da Ding Feng is mainly used for wind-driven syndrome of yin deficiency caused by long-term treatment of fever and pathogenic heat burning true yin, or wind-driven syndrome of yin deficiency caused by accidental sweating, rash attack and serious damage of vaginal fluid. It is advisable to nourish yin and extinguish wind. In the prescription, black-bone chicken and donkey-hide gelatin are the monarch, nourishing yin and calming the wind. Reuse Radix Paeoniae Alba, Radix Rehmanniae, and Radix Ophiopogonis to nourish yin and soften liver, and strong water contains wood; Carapax et Plastrum Testudinis and Carapax Trionycis are both minister drugs for nourishing yin and suppressing yang. Horse people moisten dryness and fat, nourish yin and moisten dryness; Oysters are salty and cold, calming the liver and suppressing yang; Schisandra chinensis tastes sour and good, and it is compatible with various yin-nourishing drugs, but it converges to true yin, and it also has the function of sour and sweet yin when combined with roasted licorice. The above drugs strengthen the function of nourishing yin and calming wind, supplemented by * * *. Glycyrrhiza uralensis Fisch is also a medicine for harmonizing various medicines. [ 1]
Dading wind beads are mainly donkey-hide gelatin and black-bone chicken, which nourish yin and extinguish wind; Radix Paeoniae Alba, Fructus Schisandrae Chinensis and Glycyrrhizic acid are sweet to yin, nourishing yin and softening liver; Rehmannia glutinosa, Ophiopogon japonicus and Fructus Cannabis nourish yin, nourish blood and moisten dryness; Tortoise shell, turtle shell and oyster nourish yin and suppress yang, and the whole prescription focuses on nourishing yin and suppressing yang and calming wind [6].
In Dading Zhu Feng Formula, the nourishing yin and nourishing liquid of black-bone chicken and donkey-hide gelatin is mainly composed of calming wind; Rehmannia glutinosa, Ophiopogon japonicus, Radix Paeoniae Alba, Carapax et Plastrum Testudinis, Carapax Trionycis, and Concha Ostreae nourish yin and suppress yang, while Radix Glycyrrhizae Preparata and Fructus Schisandrae acidify yin to prevent the dissipation of qi and yin, and Fructus Cannabis nourish yin and moisten dryness. The above herbs have synergistic effects, which have the effects of nourishing body fluid and nourishing yin, softening liver and calming wind [2].
This prescription is caused by fever due to long illness, pathogenic heat burning true yin, or accidental sweating, rash attack and serious injury of vaginal fluid. Due to deficiency of true yin, mental fatigue, weak pulse, red tongue with little fur, sometimes it tends to take off. Yin deficiency means that water does not contain wood, which makes deficiency wind move internally, but carbuncle of hands and feet. At this time, the pathogenic factors have reached 89, and only one or two true yin are left. Therefore, it is appropriate to treat nourishing drugs, nourish yin and promote fluid production, replenish deficiency and exhaust true yin, and calm down the deficiency wind of internal movement. [4]
8 Use 1. This prescription is a commonly used representative prescription for treating yin deficiency and wind-moving syndrome in the late stage of epidemic febrile disease. The key points of syndrome differentiation and treatment are deficiency of true yin, deficiency of internal wind, fatigue and carbuncle, weak pulse and less crimson fur [1].
2. Add and subtract: asthma, ginseng; Spontaneous sweating plus Os Draconis, Ginseng Radix and Wheat; Poria cocos, ginseng and wheat are also added. Asthma, spontaneous sweating and palpitation are all syndromes of qi deficiency, so ginseng is used to replenish qi and promote fluid production, and keel and wheat are added respectively to stop sweating and soothe the nerves and calm palpitation [1].
3. Precautions for use: It is not suitable for those with vaginal fluid deficiency and excessive pathogenic heat [1].
9 modern indications [4]
Indications: Late stage of fever.
9. 1 Epidemic febrile diseases Most of the so-called epidemic febrile diseases refer to serious diseases such as mumps, epidemic cerebrospinal meningitis, Japanese encephalitis, epidemic hemorrhagic fever, plague, cholera, infectious mononucleosis, polio, infectious viral hepatitis, scarlet fever, septicemia and typhoid fever. Clinically, most of these diseases are critical. When they enter the late stage, some of them are in a state of dying, and some of them are free from death and enter the recovery period. Clinically, there are many organ dysfunction, including brain, heart, liver, kidney, lung, circulation and blood failure, and even mild organ dysfunction, especially the immune function of virus-infected people is seriously damaged, nutrition and energy are lacking, fat and protein are disordered, water, salt and electrolyte are lacking, and acid-base balance is unbalanced. The so-called carbuncle is spasm and convulsion, which are mostly caused by brain dysfunction. It can also be caused by electrolyte disorder, water-salt imbalance, acid-base imbalance and trace element deficiency. The so-called "weak pulse, always want to take off" is an endangered state such as severe dehydration, shock or serious failure of other organs such as heart and brain. Because epidemic febrile diseases involve a wide range, they can't correspond to modern medical diseases one by one, and the etiology and pathogenesis are hard to describe. This theory is for reference only.
10 pharmacological action of dading Zhu Feng [7]
10. 1 Effect on metabolic function The yolk contained in the royal medicine egg yolk can be used to extract lecithin. Lecithin is an essential substance to maintain the stability of colloidal solution in vivo, which can promote the combination of cholesterol and protein, reduce plasma cholesterol and reduce the infiltration of fat into blood vessel wall. It also contains calcium, phosphorus, iron, vitamin A, thiamine, riboflavin, nicotinic acid, a lot of fatty substances, various protein and amino acids. Colla Corii Asini contains a large number of essential amino acids, as well as more than 20 kinds of macro and trace elements such as potassium, sodium, calcium, magnesium, iron, copper, aluminum, manganese, zinc, chromium, platinum, lead, nickel, silver, nickel, strontium, barium, titanium and zirconium. Tortoise shell also contains a large number of essential amino acids and trace elements such as chromium, manganese, copper, zinc, phosphorus, magnesium, iron, potassium, calcium, aluminum, sodium and strontium, among which strontium, zinc and copper are the highest. Carapax Trionycis contains a large amount of collagen, Trionyx sinensis sugar and 17 kinds of essential amino acids, as well as many trace elements such as calcium, sodium, potassium, copper, aluminum, manganese, zinc, phosphorus and magnesium. Concha Ostreae, an auxiliary material, contains a lot of the above amino acids, fatty acids, macro and trace elements, as well as silicon, nickel, iodine, selenium, cobalt and molybdenum, and also contains a lot of vitamin A, vitamin B 1, vitamin B2, vitamin B6, vitamin D and vitamin E, etc. Rehmannia glutinosa also contains more than 20 trace elements. These substances play a vital role in maintaining human metabolism, among which potassium, sodium, calcium, magnesium, iron, copper, zinc, cobalt, manganese, selenium, chromium, aluminum, barium, phosphorus, titanium and strontium are the most concentrated. There are also a lot of vitamin A, vitamin B, vitamin C, vitamin E and various amino acids. Among them, calcium, magnesium, sodium and potassium maintain the excitability of neuromuscular. Calcium is not only involved in the process of osteogenesis and blood coagulation, but more importantly, it is an agonist of many enzymes and a messenger to regulate cell function. Intracellular calcium, as the second messenger, plays an important role in regulating muscle excitation-contraction coupling factor, hormone and neurotransmitter secretion coupling factor and body temperature central set point. Magnesium is an auxiliary factor and agonist of many enzymes, which can start more than 300 kinds of enzymes. In addition to participating in important metabolic processes in the body, magnesium is closely related to almost all aspects of life, such as the generation and transmission of nerve impulses and muscle contraction. In particular, magnesium regulates intracellular potassium. Magnesium deficiency can lead to intracellular potassium escape and induce hypocalcemia. At this time, there are many symptoms of central nervous system dysfunction such as insanity and lethargy, and cardiovascular symptoms such as arrhythmia. Iron is the main component of hemoglobin, myoglobin, cytochrome system, the main complex of electron transfer chain, peroxidase and so on. At the same time, it is an important element for catecholamine to synthesize rate-limiting enzyme. When iron is deficient, not only anemia will appear, but also nervous system symptoms such as irritability and inattention will appear. Zinc is related to the activities of more than 80 enzymes in the body, such as carbonic anhydrase, DNA and RNA polymerase. Many protein, such as trans-acting factors, steroid hormones and thyroid hormone receptors, all have zinc finger structures, which play an important role in transcription regulation, so zinc deficiency will inevitably lead to metabolic disorders; At the same time, zinc also participates in the synthesis of growth hormone and promotes immune function. More importantly, zinc deficiency will seriously affect brain function and aggravate mental depression. Copper is an auxiliary group of many enzymes in the body, such as cytochrome oxidase. Copper ion is indispensable in the process of electron transfer to oxygen. In addition, monoamine oxidase and SOD are also copper-containing enzymes. Copper deficiency will affect the activity of some enzymes, show nervous system symptoms, cause anemia, cause myocardial damage and metabolic disorder, and make neutrophils and lymphocytes function low. Selenium is the active center of glutathione peroxidase (GSHPx), and each enzyme molecule can combine with four selenium atoms. GSHPx can use H2O2 to reduce toxic peroxide to nontoxic hydroxide, thus protecting cell membrane. At the same time, selenium can strengthen the antioxidant effect of vitamin E, and vitamin E can transform oxygen free radicals and hydroxyl free radicals (ROO) into nontoxic reproductive quinone, which has antioxidant effect. At the same time, selenium is also involved in the synthesis of coenzyme Q and coenzyme A. Selenium deficiency can often induce dilated heart disease and increase the incidence of cancer. When chromium is deficient, the biological activity of insulin decreases, leading to atherosclerosis and growth and development stagnation. Manganese is a component and activator of many enzymes, such as RNA polymerase and SOD. Manganese deficiency can directly affect brain function, make nervous system function disorder, affect reproductive function, and reduce the number of insulin and pancreatic β cells. Cobalt is an important component of vitamin B 12, which has a direct impact on nerve function. At the same time, cobalt and manganese are both essential elements for thyroxine synthesis. Cadmium can detoxify lead.
Vitamin A can promote the absorption of body fat, protein in food, bile salts and vitamin E, and promote the growth of bones, skin and mucous membranes. Vitamin D can promote the absorption and metabolism of calcium and phosphorus, and promote bone growth. Vitamin B 1 is an essential substance for glucose metabolism. When vitamin B 1 is deficient, glucose oxidation is blocked and neurovascular symptoms appear in clinic. Vitamin B _ 2 is a component of the auxiliary group of xanthase in the body, which affects the biological oxidation of the body and causes metabolic disorder when lacking. Vitamin E is a free radical scavenger, which directly participates in lipid metabolism and promotes the secretion of reproductive hormones. Vitamin B6 is a coenzyme of amino acid transferase, dehydrogenase and racemase, and directly participates in the metabolism of many amino acids.
At the same time, most of the herbs in the prescription are rich in nutrition, especially various amino acids and essential amino acids are the basic substances for the synthesis of protein and various enzymes in the body, and various sugars and fats are beneficial to the synthesis and metabolism of substances needed in the body.
Total glucosides of Paeonia lactiflora can regulate blood lipid, MDA and TC/LDL, and increase HDL at high dose. The phenylethanoid glycosides contained in Rehmannia glutinosa and Rehmannia glutinosa can inhibit enzyme activity, and aldose reductase inhibitors are used to treat diabetic syndrome and lower blood sugar. Ophiopogon japonicus and its polysaccharides have obvious hypoglycemic effect and can promote the functional recovery of islet cells. Tortoise shell can increase serum alkaline phosphatase activity, increase bone calcium and magnesium content and bone mineral density. Hemp seed oil can reduce serum total cholesterol, triacylglycerol, low density lipoprotein cholesterol and increase serum high density lipoprotein cholesterol. Oysters can also reduce serum total cholesterol, triglycerides and low-density lipoprotein. Schisandra chinensis can promote the synthesis of DNA, RNA and protein in brain, promote the production of hepatic glycogen, and increase the content of cAMP in plasma and liver tissue. Glycyrrhiza uralensis Fisch also has the function of reducing blood lipid.
It can be seen that this recipe can promote and regulate protein metabolism, fat metabolism, glucose metabolism and the activities of various enzymes in vivo.
Effects of 10.2 on nervous and endocrine functions; Black-bone chicken, the monarch medicine, has the function of strengthening the brain and body. The official drug Paeonia lactiflora and its total glucosides can obviously inhibit EEG activity, reduce the contents of calcium, sodium and water in the brain, thus alleviating brain edema; At the same time, Paeonia lactiflora has sedative, hypnotic, analgesic and anticonvulsant effects, which can promote brain learning and short-term memory; More importantly, TGP can regulate the hypothalamus-pituitary-adrenocortical axis biphasic according to the functional state of the body, thus coordinating various functions of the nervous and endocrine systems and restoring the balance of the body. Total glucosides of paeony can also improve the brain's hypoxia tolerance. Rehmannia glutinosa not only has the central sedative effect, but also can reduce the effect of glucocorticoid on the function and morphology of pituitary-adrenal cortex system and increase the plasma corticosterone concentration. Maidong decoction has sedative effect, has synergistic effect on the sedative and hypnotic effects of pentobarbital sodium and chlorpromazine, and antagonizes the exciting effect of coffee. Ophiopogon japonicus can enhance the function of pituitary-adrenal cortex system and improve the adaptability of the body. Tortoise shell can promote the proliferation of neural stem cells after focal cerebral ischemia, relieve the symptoms of nerve injury, effectively reduce the thyroid function of hyperthyroidism patients, reduce the contents of T3 and T4 in serum, restore the growth of atrophic thyroid, and reduce the thyroid function of hyperthyroidism patients. More importantly, Biejiajian Pill can restore the growth of adrenal cortex, thicken the globular zone of cortex, increase the cell body of fasciculate zone, enrich the cytoplasm and increase the weight of adrenal gland, thus reducing the function of adrenal cortex in hyperthyroidism patients. The auxiliary material hemp seed has analgesic effect. Schisandra chinensis has an exciting effect on all levels of the central nervous system, and has an influence on the exciting and inhibiting process of the cerebral cortex, making it tend to be balanced. Therefore, it can regulate the function of nervous system, stimulate spinal cord reflex, strengthen the excitation and inhibition of conditioned reflex, make the two processes tend to be balanced, improve the regulation of cerebral cortex, thus improving work efficiency and producing anti-fatigue effect; The ethanol of Schisandra chinensis seeds also has obvious sedative effect, which can resist the central excitatory effect of amphetamine and has synergistic effect on the sedative and hypnotic effects of pentobarbital sodium and chlorpromazine. Pentanol also has anticonvulsant effect. Intravenous drip of glycyrrhizic acid can improve the activities of mitochondrial ATPase and lactate dehydrogenase after global cerebral ischemia-reperfusion and alleviate brain edema. At the same time, licorice FM 100 has sedative, analgesic and anticonvulsant effects. More importantly, it can stimulate hypothalamus-pituitary-adrenal cortex axis and enhance cortisol secretion.
It can be seen that this prescription not only has sedative and analgesic effects on the central nervous system, but also can alleviate brain edema, protect brain cells and alleviate brain damage caused by ischemia/reperfusion. More importantly, four kinds of Chinese herbs and 1 Chinese herbs have the same exciting and protective effects on hypothalamus-pituitary-adrenocortical axis, which increases the secretion and release of glucocorticoid and mineralocorticoid by pituitary and the release of various endocrine hormones, thus further regulating water and salt metabolism, fat, protein and adrenocortical axis. More importantly, the "permission" function of glucocorticoid can coordinate other nerve and endocrine hormones in the whole body to play a role and restore the balance of various skills of the body. Mineralocorticoid can regulate the metabolism of water and salt in the whole body, restore the effective circulation balance and reduce the loss, thus improving the syndrome of "pulse deficiency, always wanting to get rid of".
10.3 effect on immune function: Ejiao can promote lymphocyte transformation, promote NK cell function, increase phagocytosis percentage and phagocytosis index of macrophages, resist the inhibition of hydrocortisone on immune function, and increase the specific rosette rate of the body; At the same time, Ejiao can significantly improve the body's cold resistance, with anti-fatigue and anti-radiation effects. Paeonia lactiflora, a minister medicine, has a biphasic regulation effect on humoral immunity, cellular immunity and nonspecific immunity according to the state of the body, that is, those with enhanced immunity are inhibited and those with decreased immunity are enhanced. Rehmannia glutinosa and its polysaccharides have obvious immune enhancement effect, and protect the immune function of the body by blocking some links of dexamethasone and cyclophosphamide. At the same time, Rehmannia glutinosa can obviously enhance the DNA synthesis of lymphocytes and the production of protein and IL-2 induced by ConA. Ophiopogon japonicus can significantly increase the weight of spleen, enhance the phagocytosis of reticuloendothelial system, increase peripheral white blood cells, improve immune function, and antagonize the decline of white blood cells caused by cyclophosphamide and 60Co irradiation. * * * Lysin production in serum. Tortoise shell can enhance humoral immune function and cellular immune function, and its decoction can improve lymphocyte transformation rate and antibody IgG in blood, enhance phagocytosis of macrophages, and antagonize the damage and inhibition of immune organ function. Trionyx sinensis can significantly improve cellular immune function, promote lymphocyte transformation and improve phagocytosis of macrophages. Adjuvant oyster can significantly improve immune function, and oyster water extract can significantly improve macrophage phagocytosis and lymphocyte transformation rate; Oyster hot water extract can significantly increase the number of spleen antibody-producing cells and antibodies. Schisandra chinensis has similar adaptability to ginseng, which can enhance the body's defense ability against nonspecific * * * *; The crude polysaccharide of Schisandra chinensis can improve the nonspecific immune function and increase the number of white blood cells in peripheral blood. Schisandra chinensis oil emulsion can promote cellular immune function and promote DNA synthesis of lymphocytes; Pentanol can inhibit immune function, humoral immune function and cellular immune rejection. Glycyrrhizic acid contained in Glycyrrhiza uralensis Fisch can enhance the activity of NK cells, induce interferon, enhance the activity of reticuloendothelial system, and promote the weight gain of spleen and thymus. Glycyrrhiza polysaccharide can improve the function of reticuloendothelial system and monocytes; Glycyrrhizin can enhance IL-2 secretion of lymphocytes induced by ConA, inhibit mast cell degranulation, and inhibit histamine release induced by IgE and ConA compound 48/80. Licorice Lx can reduce the amount of antigen, thus having anti-allergic effect. Glycyrrhetinic acid can increase the lymphocyte ratio, β glycyrrhetinic acid is an inhibitor of the classical pathway of human complement, and monoamine glycyrrhizinate can increase the level of INFα.
To sum up, all kinds of traditional Chinese medicines in this prescription have the same promotion and regulation effects on immune function, which is a very important treatment measure for hypoimmunity and inhibition in the late stage of various epidemic febrile diseases.
Effects of 10.4 on heart, circulation and blood function; The monarch drug Ejiao can increase the permeability of disease-resistant blood vessels, reduce plasma exudation, maintain effective circulation to a certain extent, help microcirculation blood perfusion return to normal, improve hemodynamics, and make blood pressure quickly return to normal for hemorrhagic shock, anaphylactic shock and endotoxic shock; Ejiao can promote hematopoietic function and make hemoglobin, red blood cells and white blood cells of anemia patients return to normal quickly; Collagen is contained in Ejiao, which is sticky and can adhere to the surface of capillaries, shortening the time of blood coagulation and hemostasis. Paeonia lactiflora and its total glycosides can increase myocardial nutritional blood flow, antagonize myocardial ischemia caused by pituitrin, dilate blood vessels and lower blood pressure; The extract of Paeonia lactiflora has inhibitory effects on enkephalin receptor, α adrenergic receptor, angiotensin Ⅱ receptor, β hydroxyβ methylglutaric acid coenzyme A, etc. It can also inhibit platelet aggregation induced by ADP and arachidonic acid to varying degrees, reduce the wet weight of platelets and inhibit thrombosis. Rehmannia glutinosa has the effect of strengthening the heart, especially for people with weak heart. At the same time, it can dilate renal blood vessels and has diuretic effect. Rehmannia glutinosa can reduce blood pressure by increasing cAMP and reducing cGMP/cAMP ratio; Rehmannia glutinosa and Rehmannia glutinosa polysaccharide can promote bone marrow hematopoiesis, obviously increase the colony forming unit rate of granulocyte progenitor cells, and promote the recovery of granulocyte progenitor cells caused by cyclophosphamide and radiation. Ophiopogon japonicus and its saponins can obviously enhance myocardial contractility and cardiac output, and increase coronary blood flow, but it has inhibitory effect at high dose. Ophiopogon japonicus injection can improve left ventricular function and anti-shock, reverse the inhibitory effect of hemorrhagic shock on cardiac function, improve circulation and raise blood pressure. Ophiopogon japonicus injection can obviously alleviate the hypoxia injury of myocardial cells, narrow the necrosis range of myocardial infarction, increase the nutritional blood flow of myocardial infarction, quickly repair and protect ischemic and hypoxic myocardial cells, and has anti-arrhythmia effect. Ophiopogon japonicus saponins can also act on sodium-calcium channels of myocardial cells, reduce the influx of Na+ and Ca2+ outside myocardial cells, reduce the self-discipline of myocardial cells, slow down conduction, help unidirectional block to become bidirectional block, and eliminate reentry excitation. Tortoise shell can increase coronary blood flow, improve myocardial hypoxia tolerance and have anti-arteriosclerosis effect. Carapax Trionycis can significantly increase hemoglobin and promote hematopoietic function. Hemp seed tincture can reduce blood pressure after removing ethanol and making emulsion. Oyster extract has anti-atherosclerosis effect. The water extract of Schisandra chinensis can block myocardial β 1 receptor, weaken myocardial contractility, slow down heart rate, increase the activities of RNA and metabolic enzymes in myocardial cells, and strengthen and regulate energy metabolism of cells. Improve myocardial nutritional function; At the same time, Schisandra chinensis can improve coronary blood flow and relax vascular smooth muscle. Therefore, licorice flavonoids contained in medicinal licorice have anti-arrhythmia effect; Glycyrrhetinic acid has angiotensin Ⅱ AT1receptor agonist-like effect, which can narrow the range of myocardial infarction. Glycyrrhizin can cause reactive blood pressure increase, and licorice has anti-atherosclerosis effect.
It can be seen from the above that all the traditional Chinese medicines in this prescription have the functions of improving myocardial function, promoting circulation and hematopoiesis, which is particularly important for treating severe anemia and cardiac insufficiency in the late stage of epidemic febrile disease.
10.5 Anti-inflammatory and antioxidant effects Total glucosides of Paeonia lactiflora, the official drug, can inhibit the excessive secretion of IL 1, TNF and PGE2. Paeonia lactiflora has obvious anti-inflammatory effect on various experimental nonspecific inflammation and immune inflammation, and has different degrees of inhibition on the increase of capillary permeability, exudation, edema and proliferation of inflammation. Total glucosides of Paeonia lactiflora and Paeonia suffruticosa can significantly inhibit the oxidative hemolysis of erythrocytes caused by H2O2, scavenge oxygen free radicals and hydroxyl free radicals, and inhibit the formation of LPO. Rehmannia glutinosa has anti-inflammatory and detumescence effects, and it can also enhance GSHPx activity and reduce LPO content. Maimendong decoction can significantly improve the activity of SOD in red blood cells, the total antioxidant capacity of serum, the activity of GSHPx and the content of MDA in serum, and has a strong scavenging effect on active oxygen free radicals. Copper is the catalyst of redox system. Guiban decoction can resist the increase of serum copper in patients with hyperthyroidism and yin deficiency, so it has antioxidant effect. Adjuvant hemp seed also has anti-inflammatory effect, which can inhibit the increase of vascular permeability of inflammation. Schisandra chinensis and its components have protective effects on the damage caused by oxygen free radicals. Schisandrin A can directly scavenge oxygen free radicals, significantly inhibit the decrease of myocardial mitochondrial membrane fluidity caused by adriamycin, significantly inhibit the production of malondialdehyde caused by adriamycin in the presence of Fe2+, inhibit erythrocyte hemolysis and membrane lipid peroxidation caused by hydrogen peroxide, significantly increase the activities of SOD and GSHPx in serum, and reduce the contents of LPO and MDA. Glycyrrhiza uralensis Fisch has the same anti-inflammatory effect as that of hydrocortisone, and has inhibitory effects on stage ⅰ, ⅱ and ⅲ inflammation and immune inflammation. Glycyrrhizic acid and glycyrrhetinic acid can also inhibit the production of free radicals and lipid peroxides and have antioxidant effects.
Effect of 10.6 on pathogenic microorganisms The decoction of Radix Paeoniae Alba has inhibitory effect on many pathogenic bacteria, such as Shigella dysenteriae, Escherichia coli, Staphylococcus, Pseudomonas aeruginosa and so on. It also has inhibitory effect on many fungi and direct antiviral effect. The water extract of Rehmannia glutinosa has inhibitory effect on tinea pedis and other fungi. Ophiopogon japonicus can inhibit a variety of bacteria, such as Staphylococcus albus, Bacillus subtilis, Escherichia coli, typhoid Bacillus and so on. Schisandra chinensis has inhibitory effects on Staphylococcus aureus, pneumonia, intestinal salmonella and Pseudomonas aeruginosa. Glycyrrhiza uralensis Fisch not only has inhibitory effect on some of the above bacteria, but also has inhibitory effect on Streptococcus B, Pseudomonas aeruginosa and Helicobacter pylori, and also has broad-spectrum antiviral effect. Glycyrrhrizae Radix polysaccharide also has inhibitory effects on vesicular stomatitis virus, herpes simplex virus type I and vaccinia virus. Glycyrrhizic acid has a strong inhibitory effect on coxsackie virus, adenovirus and syncytial virus. Monoamine glycyrrhizinate can inhibit HIV, and glycyrrhizin can inhibit hepatitis virus as well as the above virus. The hot water extract of Glycyrrhiza uralensis Fisch can kill Clonorchis sinensis, while Glycyrrhiza uralensis Fisch can kill mycobacterium tuberculosis, amoeba and trichomonas.
Body surface area calculator body mass index calculation and evaluation of female safety period calculator expected date calculator normal weight gain during pregnancy medication safety classification (FDA) five elements and eight characters adult blood pressure evaluation body temperature level evaluation diabetes diet suggestion clinical biochemical common units conversion basal metabolic rate calculation sodium supplement calculator iron supplement calculator prescription common Latin abbreviations quick check pharmacokinetics common symbols quick check effective plasma osmotic pressure calculator alcohol intake calculator.
Encyclopedia of medicine, count now!
10.7 on the function of digestive system. Paeonia lactiflora has protective effect on various experimental liver injuries, can resist eosinophilic degeneration and necrosis of liver tissue, and also has protective effect on immune liver injury; Shaoyao Gancao Decoction can inhibit pancreatic amylase activity, paeoniflorin and paeonol can inhibit gastric acid secretion, and have anti-ulcer effect, which has synergistic effect when combined with Glycyrrhiza FM 100. Paeonia lactiflora and Glycyrrhiza uralensis Fisch can inhibit the release of acetylcholine from parasympathetic nerve endings and have obvious spasmolytic effects. Rehmannia decoction can also protect liver cells, prevent glycogen reduction and protect gastric mucosa from damage. Maimendong decoction can inhibit gastrointestinal propulsion. Biejiajian Pill has anti-hepatic fibrosis effect. Hemp seed has the functions of benefiting gallbladder, promoting bile secretion and resisting ulcer. Oyster can inhibit gastric acid secretion, reduce pH value and pepsin activity, and has anti-ulcer effect. Schisandra decoction has protective effect on liver injury. Schisandra chinensis can promote the biosynthesis of protein and glycogen in hepatocytes and accelerate the repair and regeneration of hepatocytes. Schisandrin A, Schisandrin B and Schisandrin C can significantly increase the content of cytochrome P450 in liver microsomes, promote the synthesis of liver drug enzymes, and enhance the activity of liver drug enzymes, thus enhancing the detoxification ability of liver. Schisandra chinensis can improve the activities of SOD and CAT in liver, improve the function of glutathione oxidation system in liver, reduce the damage of oxygen free radicals to liver cells, inhibit lipid peroxidation in liver microsomes, reduce the production of MDA, protect the structural integrity and normal function of liver cell membrane, enhance the function of adrenal cortex and reduce the inflammatory reaction of liver cells. Therefore, Schisandra chinensis can significantly reduce hepatocyte necrosis, prevent hepatic steatosis, resist hepatic fibrosis, reduce ALT and AST, and significantly improve liver function. At the same time, schisandrin A can inhibit gastric acid secretion. Licorice, glycyrrhizic acid, glycyrrhetinic acid, glycyrrhizin and other drugs. Has liver protecting effect, and can inhibit hepatic steatosis and hepatic fibrosis; It can promote bile secretion and has anti-ulcer and antispasmodic effects. Glycyrrhiza FM 100 has papaverine-like spasmolytic effect.
1 1 Song Formula Dading Black Chicken, and then add and subtract Fumai Decoction; The compatibility of Sanjia and Schisandra chinensis, nourishing yin and calming wind, is a wonderful prescription. [ 1]
12 source