Different business scope: Bookstore is a publishing organization integrating editing, printing, publishing and distribution; Bookstores mainly sell books.
There are different kinds of books: publishing houses generally publish textbooks for primary and secondary schools, ancient books, various scientific, literary and artistic works and reference books; Bookstores usually offer a wider range of books, including novels, comics and other types of books.
Different in nature: bookstores mainly publish books; Bookstores are for profit.