Legend originated from Shennong and was handed down from generation to generation. It was compiled into a book in the Eastern Han Dynasty. The book was not written in a moment, and the author was not alone. Many medical scientists in Qin and Han dynasties collected, summarized and sorted out the monographs on pharmaceutical experience at that time, which was the first book in China to systematically summarize traditional Chinese medicine. Most theories and compatibility laws of TCM and the principle of "seven emotions in harmony" have played a great role in the practice of medication for thousands of years and are the source of the development of TCM theory.