Contents 1 Pinyin 2 Standards issued by the Ministry of Traditional Chinese Medicine 2.1 Pinyin name 2.2 Standard number 2.3 Preparation method 2.4 Properties 2.5 Inspection 2.6 Content determination 2.7 Functions and indications 2.8 Usage and dosage 2.9 Specifications 2.10 Storage Appendix: 1 Wild medicinal herbs in ancient books Papaya injection 1 Pinyin
yě mù guā zhù shè yè 2 Standard issued by the Ministry of Traditional Chinese Medicine 2.1 Pinyin name
Yemugua Zhusheye 2.2 Standard number
WS3B400398
This product is a sterilized aqueous solution extracted from wild papaya. 2.3 Preparation method
Take 2500g wild papaya, add water and boil it three times, 2 hours each time, combine the decoctions, filter, concentrate the filtrate under reduced pressure to 1000ml, add 5000ml ethanol, mix well, refrigerate, and let stand Precipitate, filter, recover the ethanol under reduced pressure of the filtrate, add water to 500ml; adjust the pH value to 2.0 with 6mol/L hydrochloric acid solution, refrigerate, and leave to precipitate, filter, adjust the pH value of the filtrate to neutral with 20% sodium hydroxide solution, Concentrate under reduced pressure into a thick paste, add 8 times the amount of ethanol, mix well, refrigerate, leave to precipitate, filter, recover the ethanol from the filtrate under reduced pressure, add 500ml of water for injection, and adjust the pH to 7.0~ with 8 sodium hydroxide solution 7.5, add 10g polysorbate 80 and 10ml benzyl alcohol, add water for injection to 1000ml, add 2g activated carbon, stir, filter, pot, and sterilize, and it is ready.
2.4 Properties
This product is a brown clear liquid. 2.5 Check
The pH value should be 5.5~7.0 (Appendix VII G). Hemolysis test: Take 0.3ml of this product, add 2.2ml of physiological saline and 2.5ml of 2.0 rabbit red blood cell physiological saline suspension, shake well, place in a constant temperature water bath of 36.5℃±0.5℃, observe for half an hour, and there should be no hemolysis. Others should comply with the relevant regulations under injections (Appendix I U). 2.6 Content determination
Preparation of the reference solution: Precisely weigh 100 mg of the rutin reference substance that has been dried under reduced pressure at 120°C to a constant weight, place it in a 100 ml measuring bottle, add 70 ml of 60 ethanol, and place it on a water bath to heat slightly. Dissolve, let cool, dilute to volume with 60% ethanol, and shake well. Precisely measure 10ml, place it in a 50ml measuring bottle, add water to the mark, shake well, and you have it (each 1ml contains 0.2mg anhydrous rutin).
Preparation of the standard curve: Precisely measure 0.0, 1.0, 2.0, 3.0, 4.0, 5.0 and 6.0ml of the reference solution into 25ml measuring bottles, add water to each to 6ml, and add 1ml of 5 sodium nitrite solution , mix well, leave for 6 minutes, add 1ml of 10 aluminum nitrate solution, shake well, leave for 6 minutes, add 10ml of sodium hydroxide test solution, add water to the mark, shake well, leave for 15 minutes, and measure spectrophotometry (Appendix V B ), measure the absorbance at a wavelength of 500 nm, and draw a standard curve with the absorbance as the ordinate and the concentration as the abscissa.
Measurement method: Precisely measure 5ml of this product, place it in a 25ml measuring bottle, follow the method under the standard curve preparation section, starting from "add water to each to 6ml", and measure the absorbance according to the law. Dilute 5 ml of the test sample with water to 25 ml as a blank, and measure the absorbance according to the law. Read the weight (μg) of rutin in the test sample from the standard curve and calculate it.
Each 1ml of this product contains total flavonoids calculated as rutin (C27H30O16), which shall not be less than 0.12mg. 2.7 Functions and indications
It can dispel wind and relieve pain, relax muscles and activate collaterals.
Used for trigeminal neuralgia and sciatica caused by wind evil blocking collaterals. 2.8 Usage and dosage
Intramuscular injection, 2 to 4 ml at a time, twice a day. 2.9 Specifications
2ml each 2.10 Storage
Sealed and shielded from light.
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