2 English reference Fangfeng [Xiangya Medical Dictionary]
Saposhnikovia root [Xiangya Medical Dictionary]
Saposhnikovia root [Xiangya Medical Dictionary]
Fangfeng [Chinese Medicine Terminology Committee]. Terminology of Traditional Chinese Medicine (2004)]
Fangfeng [Chinese Medicine Terminology Review Committee]. Terminology of Traditional Chinese Medicine (2004)]
3. National essential drugs and the retail guidance price information of essential drugs related to Fangfeng.
Essential drug serial number
DirectoryNo. Drug name, dosage form and specification Retail unit refers to
Remarks Price category 55 5 Fangfeng Tongsheng Pill 6g package 0.65 Chinese patent medicine part * 56 5 Fangfeng Tongsheng Pill Shuiwan 12g bag 1 .2 Chinese patent medicine part 57 5 Fangfeng Tongsheng Pill Water Pill 30g bottle 2.9 Chinese patent medicine part 58 5 Fangfeng Tongsheng Pill Water Pill 36g bottle 3.4 Chinese patent medicine part 59 5 Fangfeng Tongsheng Pill Water Pill 48g bottle 4.5 Chinese patent medicine part 60 5 Fangfeng Tongsheng Pill Water Pill 50g bottle 4.6 Chinese patent medicine part 6 1.5 Fangfeng Tongsheng Pill Water Part 62 5 Fangfeng Tongsheng Pill Water 120g bottle/ Kloc-0/.4 Chinese patent medicine part 63 5 Fangfeng Tongsheng Pill Water 300g bottle 24.3 Chinese patent medicine part 64 5 Fangfeng Tongsheng Pill Concentrated Pill 200 pill bottle 7.3. Patent part *△ 65 5 Fangfeng Tongsheng Granule 3g bag 1.7 Chinese patent medicine part * Note:
1. The dosage form specifications marked with "*" in the remarks column in the table are representative products.
2. Specifications of dosage forms with "△" in the remarks column in the table, and other specifications of the same dosage form are tentative prices.
3. The dosage form specifications are indicated in the remarks column. The prices of other specifications in this dosage form are based on the same usage and dosage, and are calculated according to the drug price comparison rules.
4. The "honey pills" marked in the column of dosage form in the form include small honey pills and big honey pills.
4 Summary Saposhnikovia divaricata is the name of traditional Chinese medicine, which comes from Shennong Herbal Classic [1]. It is the dry root of windbreak. )Schischk。 Umbelliferae [2].
Pharmacopoeia of People's Republic of China (PRC) (20 10 edition) records the pharmacopoeia standard of this Chinese medicine.
5 Latin scientific name Fangfeng (La) (terminology of traditional Chinese medicine (2004))
6. English name Fangfeng (Chinese Medicine Terminology (2004))
7 Windproof alias screen [1], Windproof Pass [1], Windproof East.
Source and place of origin: the root of Saposhnikovia divaricata. )Schischk。 [1] of Umbelliferae. Location: Jilin, Heilongjiang, Inner Mongolia, Hebei and other places [1].
9 plant morphology windbreak perennial herbs. Stem solitary, dichotomous. The basal leaves divide pinnately for 2 ~ 3 times, the terminal lobes are lanceolate, and the petiole is 2 ~ 6.5 cm long; The terminal leaves are simplified and the leaf sheaths are enlarged. Compound umbel; There is no total bract, at least 1 piece; Umbrella width 5 ~ 9; Involucral bracts 4 ~ 5; Pedicel 4 ~ 9; These flowers are yellow. Double bilberry is oblong, broadly ovoid, flat and winged on the side. The flowering period is August-September, and the fruiting period is 9-65438+1October.
10 habitat Fangfeng is born in grassland and dry hillside.
1 1 Collect radix Saposhnikoviae, dig in spring and autumn, remove fine roots and dry in the sun.
The root of 12 is cylindrical or rectangular, with a length of 15 ~ 30cm and a diameter of 0.5~2cm. The surface is grayish brown with longitudinal grooves, transverse lenticels and punctate root marks. There are dense connections at the head of the root, and there are brown hairy residual leaves at the base. The body is light and loose, the section is uneven, the skin is dark brown and cracked, and the wood is light yellow. The smell is special and the taste is slightly sweet.
13 is pungent, sweet and slightly warm [1]. Enter bladder meridian, lung meridian, liver meridian and spleen meridian [1].
The main functions of 14 are expelling wind, relieving exterior syndrome, eliminating dampness, relieving pain, relieving spasm and relieving itching [1]. It can be used for treating common cold, headache, body pain, facial paralysis, rheumatic joint pain, acute quadriplegia, abdominal pain and diarrhea, intestinal wind bleeding, wind sores and scabies, skin itching and tetanus. Stir-fry until brown, treat diarrhea; Treatment of hematochezia and metrorrhagia by frying charcoal [1].
Saposhnikovia divaricata is a commonly used medicine for expelling wind and cold in ophthalmology, which has the effects of expelling wind and removing dampness, relieving itching and pain, dispersing stagnation and regulating qi.
(1) Saposhnikovia divaricata is widely used for headache, eyelid sore, pepper sore, tears in the wind, sudden heat, dark circles and nebula caused by wind evil. It is often combined with Schizonepeta and Notopterygium to dispel pathogenic wind, such as Notopterygium and Shengfeng Decoction. If it is used to disperse wind-heat or eye diseases caused by wind-heat, it is often used with Forsythia suspensa and Scutellaria baicalensis to dispel wind and clear heat, for example, to dissipate heat and sterilize drinks.
(2) Saposhnikovia divaricata is used to treat eye itching and even nymph itching caused by wind evil. It is often combined with Schizonepeta Spike and Chuanxiong, such as Qufeng Ziyi Powder.
(3) windproof is used for wind-induced strabismus. This product can dispel wind and affect liver meridian. It is often used with Rhizoma Typhonii, Arisaema cum bile and Bombyx Batryticatus to dispel wind and resolve phlegm, such as Zheng Rong Decoction.
(4) Saposhnikovia divaricata can enter the liver and kidney meridians, connect them, and moisten the eyes. Cataract ophthalmopathy is mostly caused by deficiency of liver and kidney, inability to inherit and loss of support. Therefore, when tonifying liver and kidney, Saposhnikovia divaricata is often used as a medicine for inducing menstruation, which is helpful to enhance the drug effect and improve the therapeutic effect.
15 Saposhnikovia divaricata usage and dosage: decocted for 5 ~ 10g [1].
16 use Fangfeng: decoction to treat wind-heat sweating [1]. Saposhnikovia divaricata: decoction for abdominal pain, limb cramps and joint pain [1].
The chemical constituents of 17 root contain chromogen, Cimicifuga foetida, citrus lactone, psoralen, volatile oil, mannitol, picroside and so on [1].
18 The pharmacological effects of Saposhnikovia divaricata decoction and alcohol infusion have antipyretic effects on rabbits, as well as enhancing immune function, anti-tumor and anticonvulsant effects [1].
19 Pharmacopoeia standard Fangfeng 19. 1 is called Fangfeng.
19.2 Source This product is the dried root of Saposhnikovia divaricata. )Schischk。 Umbelliferae. In spring and autumn, the roots of plants without flower stems are dug, fibrous roots and sediments are removed, and then dried.
19.3 features: this product is oblong, conical or cylindrical, the lower part is tapered and slightly curved, with a length of 15 ~ 30cm and a diameter of 0.5~2cm. The surface is grayish brown and rough, with longitudinal wrinkles, and most of them have transverse lenticels and punctate fine root marks. There are obvious dense annual rings on the root crown, and some annual rings have brown hairy leaf bases. Light weight, loose, easily broken, uneven section, light brown skin, cracked, light yellow wood. The smell is special and the taste is slightly sweet.
19.4 Identification (1) Cross section of this product: the cork layer is 5 ~ 30 rows of cells. The inner layer of the plug is very narrow and has a large oval tube. The phloem is wide, with many round tubes, surrounded by 4 ~ 8 secretory cells, and golden yellow secretions can be seen in the tubes; Most of the rays are curved, and cracks often form on the outside. The cambium is obvious. There are many xylem vessels, which are arranged radially. The root head has pith, and occasionally there are stone cells in parenchyma.
The powder is light brown. Tubing diameter 17 ~ 60μ m, full of golden yellow secretion. Leaf-base vascular bundles are usually accompanied by fiber bundles. The diameter of reticular duct is 14 ~ 85μ m, with few stone cells, yellow-green, oblong or rectangular, and thick wall.
(2) Take 65438 0 g of this product powder, add 20ml of acetone, perform ultrasonic treatment for 20 minutes, filter, evaporate the filtrate, and add 65438±0ml of ethanol to dissolve the residue as the test solution. Another reference medicinal material, Saposhnikovia divaricata 1g, was prepared into reference medicinal material solution by the same method. Then, take cimicifugoside reference substance and 50- methyl misoprostol reference substance, and add ethanol to make a mixed solution containing 1ml as reference substance solution. According to the thin-layer chromatography test (appendix ⅵ b), 65438 00μ l of the above three solutions were absorbed, respectively spotted on the same silica gel GF254 thin-layer plate, developed with chloroform and methanol (4: 1), taken out, dried and examined under an ultraviolet lamp (254nm). In the chromatogram of the test sample, spots with the same color appear at the positions corresponding to the chromatograms of the reference medicinal materials and the reference substance.
19.5 Check that the water content of 19.5. 1 shall not exceed 10.0% (appendix ⅸ H first method).
19.5.2 the total ash content shall not exceed 6.5% (appendix ⅸ k).
19.5.3 the acid-insoluble ash content shall not exceed 1.5% (appendix ⅸ k).
19.6 the extract shall be determined by the hot soaking method under the alcohol-soluble extract determination method (appendix X A), with ethanol as the solvent, which shall not be less than 13.0%.
The content of 19.7 was determined by HPLC (Appendix VI D).
19.7. 1 chromatographic conditions and system applicability test: octadecylsilane bonded silica gel is used as filler; Methanol-water (40: 60) is the mobile phase; The detection wavelength is 254 nm. According to the peak of Cimicifuga, the theoretical plate number should be not less than 2000.
19.7.2 preparation of reference solution: take appropriate amounts of cimicifugoside reference substance and 50- methyl visamethasone reference substance, weigh them accurately, and add methanol to make a solution containing 60μg per 1ml.
19.7.3 preparation of test solution take about 0.25g of this product fine powder, weigh it accurately, put it in a conical flask with a stopper, add 10ml of methanol accurately, weigh it, reflux it in a water bath for 2 hours, let it cool, weigh it again, make up the weight loss with methanol, shake it evenly, filter it, and take the filtrate.
19.7.4 determination method Accurately suck 3μl of control solution and 2μl of test solution respectively, and inject them into liquid chromatograph for determination.
The total content of Cimicifuga foetida (C22H280 1 1) and 50- methylmisoprostol (C22H280 10) shall not be less than 0.24%.
19.8 Saposhnikovia divaricata pieces 19.8. 1 Processing to remove impurities, washing, fully wetting, cutting into thick slices and drying.
This product is a round or oval thick tablet. The outer skin is grayish brown with longitudinal wrinkles, and some transverse lenticels-like protrusions, kiln rings or residual hairy leaf bases can be seen. The cut skin is light brown with cracks, and the wood is light yellow with radial texture. The smell is special and the taste is slightly sweet.
19.8.2 Identification, inspection, extract and content determination are the same as those of the medicinal materials.
19.8.3 Sexual taste and channel tropism are pungent, sweet and slightly warm. It belongs to bladder meridian, liver meridian and spleen meridian.
19.8.4 Functions and indications: expelling wind, relieving exterior syndrome, eliminating dampness, relieving pain, and relieving spasm. Used for common cold and headache, rheumatic joint pain, rubella itching and tetanus.
19.8.5 Usage and dosage 5 ~ 10g.
19.8.6 Store in a cool and dry place to prevent insects from eating.
19.9 source: People's Republic of China (PRC) pharmacopoeia (20 10)
20