2 English reference Ganmai Jujube Soup [2 1 Century Bilingual Dictionary of Science and Technology]
Ganmai Jujube Soup [Terminology Committee of Traditional Chinese Medicine]. Terminology of Traditional Chinese Medicine (2004)]
3. Summarize the name of Ganmai Jujube Decoction, which is the alias of Ganmai Jujube Decoction recorded in Synopsis of the Golden Chamber [1]. Experimental research shows that this prescription has obvious sedative and anticonvulsant effects [1].
34 cases of intractable neurasthenia were treated with this prescription in clinic, and 30/34 cases were effective without any western medicine. The effective rate was 88%, with an average dose of 4-6, and the average dose of 13.9 was basically cured [2]. The therapeutic mechanism of this prescription, especially the therapeutic mechanism of the monarch drug wheat, deserves further discussion [2].
4 alias Ganmai jujube soup Ganmai jujube soup [1].
5. Three liang of licorice, one liter of wheat and ten jujubes [1].
9g licorice, wheat 15g, 7 jujubes [3].
9g licorice, 15 ~ 30g wheat, 5 jujubes [4].
Three liang of licorice, one liter of wheat and ten jujubes [5].
6 Usage of Ganmai Jujube Soup: Take it in water and take it three times [1].
Add appropriate amount of water to the above three herbs, decoct with slow fire, take the decoction twice and mix well [3]. Warm clothes in the morning and evening [3].
Take six liters of water, boil three liters, and warm for three times [5]
7 The effect of Ganmai Jujube Decoction is mainly to nourish the heart, soothe the nerves and relieve anxiety [1]. Treat women who are dirty, impatient, happy, sad, want to cry and count less. It is often used in patients with neurosis, hysteria, depression and so on [1].
It has the effect of nourishing the heart, calming the nerves and relieving anxiety [3].
Ganmai jujube decoction is used to treat visceral mania (equivalent to neurosis in modern medicine) [3]. Symptoms include trance, sadness, crying, upset, unable to make a decision, restless sleep, frequent yawning, memory loss, intolerance to thinking, insomnia, night sweats, less red tongue coating and rapid pulse [3].
Ganmai Jujube Decoction for Menopause Syndrome [3].
Among the 8 prescriptions, wheat is sweet and slightly cold, nourishing the heart and calming the nerves; Take licorice. And Zhong Jiyu is the minister of history; Take jujube as a supplement [1]. The combination of three herbs is sweet, nourishing, calming and urgent, which is a combination of clearing and tonifying [1].
This prescription is mainly used to treat the disorder caused by excessive anxiety, heart yin damage and liver-qi disorder, and the treatment is mainly to nourish the heart and soothe the nerves, and the harmony is urgent [3]. This prescription of wheat is sweet and slightly cold, which is the monarch drug for nourishing yin, calming the heart and calming the nerves [3]. Licorice is relieved by its sweetness; Jujube tonic, nourishing blood and calming the nerves, is an adjuvant medicine [3]. 3 the combination of things, * * * plays a nourishing role, nourishing the heart and calming the nerves, and calming the anxiety [3].
A disease of visceral mania is mostly caused by excessive anxiety, damage of heart yin and disharmony between liver and qi [4]. Deficiency of heart yin, mental dystrophy, trance, restless sleep and upset mood; If the liver-qi is not harmonious and the excretion is abnormal, then you will feel sad and want to cry, unable to make a decision, or act rashly [4]. Wheat is sweet and cool, nourishing the liver and heart, calming the heart and calming the nerves, which is the monarch medicine [4]. Ganping licorice, nourishing the heart, is a minister medicine [4]. Jujube is warm and moist, benefiting qi, harmonizing middle energizer and moistening dryness, which is an adjuvant medicine [4]. 3 drug combination, nourishing the heart and regulating the liver, * * * playing, nourishing the heart and calming the nerves, balancing priorities [4].
9 Clinical Application of Ganmai Jujube Decoction Ganmai Jujube Decoction is a representative prescription for treating visceral mania and climacteric syndrome [3]. The main points of clinical medication are sadness, trance, out of control and irritability [3].
Add and subtract: If insomnia symptoms are serious, or menstrual flow is less, the color is pale and dripping is endless, Guipi Decoction can be added and subtracted; If the tongue coating is less red and the internal heat due to yin deficiency is obvious, it can be combined with Liuwei Dihuang Pill. Xu Ruo is fidgety and dreamy, dizzy, with thin pulse and liver blood deficiency, which can be used with Ziziphus Spinosae Seed Decoction; If the mind is in a trance, forgetfulness, insomnia symptoms are obvious, the tongue is red with little fur, the pulse is thready, the heart yin is insufficient, and the heart and kidney are not harmonious, it can be used with Tianwang Buxin Dan; If the symptoms of insomnia are obvious, the tongue coating is yellow and there is phlegm heat, it can be combined with Wendan Decoction; If you are in a bad mood, upset, often yawning, and liver depression is obvious, you can use it with Xiaoyaosan or Danzhi Xiaoyaosan [3]. ? If you are upset and insomnia, your tongue is red and less coated, and your yin deficiency is obvious, add Radix Rehmanniae and Lily to nourish your heart and yin; For patients with dizziness, thready pulse and liver blood deficiency, Semen Ziziphi Spinosae and Radix Angelicae Sinensis are added to nourish the liver and replenish blood, and calm the nerves [4].
Note: It is not suitable for those who are wet and have excessive heart fire [3].
Modern indications of 10 Ganmai Jujube Decoction [4]
Ganmai Jujube Decoction is suitable for patients with hysteria, climacteric syndrome and deficiency of both heart and yin and disharmony between liver and qi.
10. 1 menopausal syndrome menopausal syndrome is perimenopausal syndrome. The disease refers to a period of time before and after menopause, including from approaching menopause age or appearing endocrine, biological and clinical features related to menopause to after the last menstruation 1 year, which is a series of physiological and psychological symptoms caused by the decrease of sex hormones. The main endocrine changes are: ovarian function decreases, estrogen secretion decreases, and low-level estrogen is transformed from adrenal cortex and ovarian tissue; During the menopausal transition, luteal phase dysfunction, progesterone secretion decreased, and postmenopausal secretion disappeared; During the transition period of menopause, the level of follicular * * * increased and luteinizing hormone remained in the normal range. Due to the decrease of estrogen level, the hypothalamus is induced to secrete gonadotropin-releasing hormone, so that the pituitary gland releases more follicles and luteinizing hormone, and the inhibin decreases, which inhibits the hypothalamus from secreting prolactin inhibitory factor, thus increasing the prolactin level. Gonadotropin releasing hormone increased and inhibin decreased. The overall level of androgen decreased after menopause, and androstenedione mainly came from adrenal gland. The main clinical manifestations are menstrual disorder, unstable vascular function, mental and neurological symptoms, cardiovascular diseases, changes in bone mineral content and osteoporosis.
10.2 The etiology and pathogenesis of hysteria are still unclear, and it should be a neurosis, and its attack is often related to external gods. More common in young women, each attack is induced by external factors, and patients often have multiple attacks. The reason and attack form of each attack are probably the same, and the attack forms are diverse, suggesting that you can terminate or attack. The common ones are: ① hysterical convulsion, limb convulsion with irregular duration, no change in pupil and breathing during the attack, which can be aggravated or terminated by suggestion, and no abnormal changes in EEG and other examinations. (2) Hysterical disorder, such patients have quite special hysterical personality, high emotions, strong suggestibility, self-centeredness and rich imagination. The manifestations are: a. mental disorder, especially in an embarrassing state; In addition, there are emotional outbursts, which can break into a furious rage for subtle reasons, make a scene, beat one's chest and feet, tear clothes, comfort and then smile through tears; It can also be characterized by paralysis and numbness. Dyskinesia, such as grand mal in hyperactivity, decreases with paralysis or aphonia. C. sensory disorders, such as blindness and hearing loss. Autonomic nerve dysfunction, such as vomiting, hiccups, hiccups, dyspnea, etc.
1 1 pharmacological action of Ganmai jujube decoction [6]
The monarch medicine wheat contains starch, protein, sugar, fat, crude fiber, fatty oil and plant lectin. Traditional Chinese medicine believes that wheat is specially used to treat rashness, while modern medicine believes that it can treat anxiety, irritability and insomnia. Dirty dryness is a trance-like state, which is often sad and crying, unable to make decisions, uneasy, restless in sleep, even speech disorder, and often yawning. This is a symptom of hysteria and neurasthenia in modern medicine. Both of them are due to external factors and the particularity of patients' individual qualities, especially huge mental disorders and trauma, which make people's nervous and endocrine functions disorder. Under severe stress, the secretion of norepinephrine can be higher. The mechanism of wheat in treating hysteria is whether some special components in wheat play a role or produce new effective compounds with other drugs during processing, which deserves further discussion. FM 100 contained in Glycyrrhiza uralensis Fisch has analgesic and anticonvulsant effects, and can promote the synthesis of corticosteroids. Glycyrrhetinic acid is similar to corticosteroids in structure, which can competitively inhibit the metabolic inactivation of corticosteroids in the liver, thus indirectly increasing the plasma concentration of corticosteroids. Glycyrrhiza uralensis Fisch is similar to corticosteroids in structure and has a direct corticosteroid-like effect, so it has a corticosteroid-like effect. Moreover, licorice can improve the endocrine regulation ability of the body by exciting the hypothalamus-pituitary-adrenal cortex axis. Locus coeruleus-noradrenergic neuron/sympathetic adrenal medullary system (CCINE) is closely related to the limbic system of the brain, and mainly descends to the lateral corner of the spinal cord, which regulates the sympathetic adrenal medullary system. The main central effect of this system is related to anxiety and tension caused by stress. Hypothalamus-pituitary-adrenocortical hormone system (HPA) is widely interrelated with nerve fibers, hippocampus and marginal cortex of amygdala complex, and it is also interrelated and regulated with pituitary and adrenal cortex through corticotropin-releasing hormone (CRH). Under pressure, HPA axis stimulates the release of CRH and ACTH, which further leads to the secretion of glucocorticoid (GC). Under severe stress, it will cause mental disorders such as anxiety and depression. The secretion of GC increases, which first "allows" the mobilization of catecholamine and glucagon; ② Inhibit all kinds of inflammatory mediators; ③ Maintain the normal reaction of catecholamine in circulation; ④ Chronic stress growth hormone was inhibited, which made the target cells resistant to insulin-like growth factor ⅰ (IGF ⅰ). In addition to growth retardation, they may have abnormal behavior and insulin resistance. ⑤ The continuous increase of GC leads to the inhibition of gonad axis, which makes gonads resistant to sex hormones and causes sexual dysfunction and menstrual disorder; ⑥ Inhibit thyroid axis and prevent T4 from transforming into T3. The effective regulation of licorice on HPA and LC/NE can restore its balance, which may be the main mechanism of its treatment of neurasthenia, menopausal syndrome and other diseases. Especially, only moderate excitement of HPA axis can help to maintain good cognitive learning ability and good mood. In addition, licorice extract can antagonize norepinephrine, and intravenous drip of glycyrrhizic acid can improve the activities of mitochondrial ATPase and lactate dehydrogenase after ischemia-reperfusion and alleviate brain edema. The auxiliary jujube contains protein, organic acid, mucus, vitamin C, vitamin D, trace elements, calcium, phosphorus, iron and various amino acids. Chinese medicine believes that jujube has the functions of invigorating the middle energizer, nourishing blood and calming the nerves. Modern medical research on jujube and jujube polysaccharide shows that jujube polysaccharide can improve the phagocytic function of mononuclear phagocytes, significantly enhance the ability of macrophages to secrete TNFα, IL 1 and NO, promote hemolysin and hemolytic plaque, and promote lymphocyte proliferation. At the same time, it has the functions of protecting the liver, strengthening muscle strength and increasing weight. How it works in neurasthenia, climacteric syndrome and hysteria is not recorded in the relevant literature. The author analyzes the possible mechanisms of jujube: ① A large number of catecholamine and glucocorticoid will inevitably inhibit the immune function during continuous stress, and the immune system will participate in stress regulation in turn besides being regulated by nerve and endocrine reactions, and at the same time, the immune system can also produce various nerve, endocrine hormones and cytokines. The nervous and endocrine systems can perceive these indecipherability. In addition, some cytokines produced by immune cells also have nerve and endocrine hormone-like effects, such as interferon (INF) can combine with opioid receptors to produce opioid analgesia; TNF can induce hypothalamus to secrete CRH and act on adrenal cortex to produce ACTH-like GC secretion. IL 1 can directly act on the central nervous system, increase body temperature and metabolism, promote the release of CRH, GH and TSH, and inhibit the secretion of prolactin and LH. IL-2 can promote the release of CRH, ACTH and endorphins, indicating that the immune system has feedback regulation on the nervous and endocrine systems. Jujube may produce a series of factors regulating the neurological and endocrine disorders by improving the phagocytic function of mononuclear phagocytes. ② Catecholamines, such as norepinephrine and epinephrine, increase obviously during stress, while tyrosinase hydroxylase is the rate-limiting enzyme, and Fe2+ is an important element for its rate-limiting, thus reducing the production of catecholamines. At the same time, hysteria is often complicated with alkalosis, which reduces blood Ca2+. Ca2+ is the stress factor of neuromuscular diseases. Jujube and licorice both contain Fe2+ and Ca2+, which can inhibit neuromuscular diseases. In addition, jujube has significant sedative and hypnotic effects. Jujube polysaccharide can scavenge free radicals in blood, and it has the strongest scavenging ability on reactive oxygen radicals in whole blood chemiluminescence. It can improve the activity of SOD and CAT in brain, reduce the content of MDA and LPO, and prevent brain atrophy and brain aging, which may have a certain positive effect on neurasthenia, climacteric syndrome and hysteria.
In addition, licorice can also enhance the activity of reticuloendothelial system, activate lymphocyte proliferation and significantly increase antibody production; Glycyrrhizin can increase the secretion of IL-2 by lymphocytes and inhibit the release of histamine by mast cells. Diammonium glycyrrhizinate can increase the level of serum INFγ, while glycyrrhetinic acid can increase the lymphocyte ratio, which may play a certain feedback regulation role in the nervous and endocrine systems.
12 melody licorice wheat jujube soup, the woman's dirty impatience is abnormal; The spirit is trance and sad, and the liver and spleen are naturally healthy [3].
13 source