Compendium of Materia Medica written by Li Shizhen, a medical scientist in Ming Dynasty, not only quoted the records of Ganoderma lucidum in ancient books, but also made textual research and comments on it. Regarding the efficacy of Ganoderma lucidum, Li Shizhen said, "It is mainly used for treating deafness, benefiting joints, protecting spirit, benefiting qi, strengthening bones and muscles, preserving complexion, keeping fit for a long time, prolonging life, treating fatigue and treating hemorrhoids". These effects have been confirmed by current pharmacological research. In the book "Flower Mirror" (1688) in Qing Dynasty, Chen introduced in detail the artificial cultivation methods of Ganoderma lucidum, such as "cultivating Ganoderma lucidum by Taoist method, mashing glutinous rice every time, adding realgar and deer blood, wrapping dried bamboo shoots and piling them in the soil from winter to sun", or "pouring the bacteria into the rotten place of old trees after the thunderstorm the next year to get various Ganoderma lucidum"
There are many discussions about the homology of medicine and food of Ganoderma lucidum. Li Shizhen pointed out: "In the past, Siliang medicinal materials were collected and eaten by immortals, and auricularia was edible, so it was moved into the vegetable department." . Tao Hongjing also pointed out: "Anyone who gets Cao Zhi only eats it, and there is nothing superfluous, so he does not follow the law." Su Jing believes: "Wisdom is rare, and you get one or two, but you are not convinced for a long time." In ancient times, there were few natural ganoderma lucidum, which not only improved its value, but also limited its wider application.