2 English reference to Angelica sinensis [Landau Chinese-English Dictionary]
Angelica sinensis, root [Xiangya Medical Dictionary]
Committee on terminology of traditional Chinese medicine. Terminology of Traditional Chinese Medicine (2004)]
Angelica sinensis [Chinese medicine terminology Committee]. Terminology of Traditional Chinese Medicine (2004)]
3 Overview Angelica is the name of traditional Chinese medicine, which comes from Shennong Herbal Classic [1]. It is the dried root of Angelica sinensis. ) Diels of Umbelliferae [2].
People's Republic of China (PRC) Pharmacopoeia (20 10 edition) records the pharmacopoeia standard of this Chinese patent medicine.
4 Latin name Angelica sinensis (La) (Chinese medicine terminology (2004))
5 English name Angelica sinensis (Chinese medicine terminology (2004))
6 The aliases of Angelica sinensis are Shi Gui and Qin Gui [1].
7 Source and place of origin Angelica sinensis (Oliv. ) Diels of Umbelliferae [1]. Location: Sichuan, Yunnan, Gansu [1].
8 Sexual taste is sweet, pungent and warm [1]. Enter the heart, liver and spleen meridians [1].
9 Functional indications should be attributed to nourishing blood and activating blood, regulating menstruation and relieving pain, moistening dryness and smoothing intestines [1].
1. Treat irregular menstruation, amenorrhea, dysmenorrhea, chronic pelvic inflammatory disease, postpartum abdominal pain and metrorrhagia [1].
2. Treat anemia, blood deficiency, headache, dizziness, intestinal dryness and constipation [1].
3. Treat abdominal mass accumulation, rheumatic joint pain, lumbar muscle strain, carbuncle swelling and ulceration, and traumatic injury [1]. Decocting: 6 ~ 15g [1]. Angelica injection is currently used to treat acute ischemic stroke, arrhythmia, early sudden deafness and osteoarthritis [1].
Angelica sinensis is a commonly used blood-enriching drug in ophthalmology, which has the effects of nourishing blood, moistening dryness, promoting blood circulation and relieving pain.
(1) is used for dizziness, headache, decreased vision, tears, itchy eyes and wind bias caused by blood deficiency. It is often used with Radix Rehmanniae Preparata and Radix Paeoniae Alba.
(2) It is used for bleeding inside and outside the eyes, which belongs to blood deficiency and blood stasis. It is often used with Eclipta prostrata, Radix Paeoniae Rubra and Rhizoma Chuanxiong.
(3) It can be used for eyelid swelling and pain, erythema, etc. It can be used with safflower, dandelion and scutellaria baicalensis.
10 chemical composition This product contains ligustilide, ferulic acid, camphoric acid, sebacic acid, myrcene, angelica acid, safrole, carvacrol, p-cresol, sphingomyelin, phosphatidylinositol, vanillic acid, neoangelica lactone, succinic acid, nicotinic acid, uracil and vitamin B 12.
Pharmacological action 1 1 Its volatile components can inhibit uterus; Non-volatile components can excite uterus [1]. Decoction or alcohol extract mainly excites the uterus in vivo and makes it contract slowly and rhythmically, which is the pharmacological basis for treating dysmenorrhea [1]. Angelica sinensis fluid extract has antiarrhythmic and antihypertensive effects [1]. It can resist myocardial ischemia and hypoxia when returning [1]. Aqueous solution can inhibit platelet aggregation and prevent thrombosis [1]. Polysaccharide can promote hematopoiesis and has anti-pernicious anemia effect [1]. It has a certain protective effect on aortic lesions in experimental atherosclerotic rats [1]. Polysaccharide can also enhance immune function [1]. The decoction has anti-inflammatory, analgesic, cholagogic and hepatoprotective effects [1]. Ligustilide can relieve asthma [1]. The extract can resist pulmonary fibrosis [1]. Polysaccharide can resist tumor [1]. The volatile oil is antimicrobial [1]. The decoction can resist oxidation and free radicals [1].
12 preparation of angelica sinensis fluid extract
13 Chinese angelica pharmacopoeia standard 13. 1 named Chinese angelica.
Chinese angelica
Chinese angelica
13.2 Source: Angelica sinensis (Oliv. ) A plant of Umbelliferae. Digging in late autumn, removing fibrous roots and sediment, slightly evaporating water, tying it into small bundles, putting it on the shed, and slowly smoking it with fireworks.
13.3 product is slightly cylindrical, with more than 3-5 branches at the lower part, and the length is 15-25 cm. The surface is yellow-brown to brown with longitudinal wrinkles and transverse lenticels. The diameter of the root head (homing head) is 1.5 ~ 4 cm, which is annular, blunt at the upper end, or has several obvious prominent rhizome marks, and purple or yellow-green stems and leaf sheaths remain; The surface of the main root (back body) is uneven; The root (tail) of the branch is 0.3 ~ lcm in diameter, thick on the top and thin on the bottom, twisted, with a few fibrous root marks. Flexible, yellow-white or yellow-brown in cross section, thick skin, cracks and most brown punctate secretory cavities, light wood color, yellow-brown cambium ring. Strong aroma, sweet, pungent and slightly bitter.
Those who are strong in firewood, dry and oil-free, or whose cross section is green and brown are not allowed to be used as medicine.
13.4 Identification (1) Cross section of this product: the cork layer is a series of cells. The inner layer of the plug is narrow and there are several oil chambers. The phloem is wide, with many cracks, and the oil chamber and tubing are round, with a diameter of 25 ~ 160μ m, with a large outside and a small inside, surrounded by 6 ~ 9 secretory cells. Form a layer, form a ring. The ray width of xylem is 3 ~ 5 rows of cells; Catheters are scattered individually or 2 ~ 3 together and arranged radially; Parenchyma cells contain starch granules.
The powder is yellowish brown. The phloem parenchyma cells are spindle-shaped, with a slightly thicker wall, and the surface has a very fine diagonal texture, and sometimes a thin membrane can be seen. Trapezoidal catheter and reticular catheter are common, with a diameter of about 80 μ m, and sometimes oil chamber fragments can be seen.
(2) Take 0.5g of this product powder, add 20ml of ether, perform ultrasonic treatment for 65438 00 minutes, filter, evaporate the liquid, and dissolve the residue with 65438±0ml of ethanol as the test solution. In addition, 0.5g of Angelica sinensis was taken to prepare a control drug solution in the same way. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia Part I, 20 10), respectively absorb the above two solutions 10μl on the same silica gel G thin-layer plate, use ethyl acetate and n-hexane (4: 1) as developing agent, unfold, take out, dry and check under ultraviolet lamp (365nm). In the chromatogram of the test sample, fluorescent spots with the same color appear at the positions corresponding to the chromatogram of the control medicinal materials.
(3) Take 3g of this product powder, add 50ml of 1% sodium bicarbonate solution, perform ultrasound 10 min, centrifuge, take supernatant, adjust the pH value to 2-3 with dilute hydrochloric acid, shake, extract with ether twice, 20ml each time, combine ether solutions, evaporate, and add 1ml methanol to dissolve. In addition, methanol was added to ferulic acid reference substance and ligustilide reference substance to prepare a solution containing 1mg per 1ml as reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia I, 20 10), the above three solutions 10μl were absorbed on the same silica gel G thin-layer plate, and cyclohexane dichloromethane ethyl acetate formic acid (4: 1: 1) was used as the developing agent. In the chromatogram of the test sample, fluorescent spots with the same color appear in the position corresponding to the chromatogram of the control sample.
The water content of 13.5.1shall not exceed 15.0% (appendix ⅸ H, second method of Pharmacopoeia I, 20 10).
13.5.2 The total ash content shall not exceed 7.0% (Appendix ⅸ k of Pharmacopoeia 20 10).
13.5.3 the acid-insoluble ash content shall not exceed 2.0% (appendix ⅸ k, part I of Pharmacopoeia 2010).
13.6 extract shall be determined by the hot soaking method under the alcohol-soluble extract determination method (Appendix X A of Pharmacopoeia I, 20 10), with 70% ethanol as the solvent, not less than 45.0%.
13.7 content determination 13.7. 1 the volatile oil was determined according to the volatile oil determination method (Appendix XD B of Pharmacopoeia 20 10).
This product contains no less than 0.4% (ml/g) of volatile oil.
13.7.2 ferulic acid was determined by high performance liquid chromatography (Appendix VI D, Pharmacopoeia I, version 20 10).
13.7.2. 1 chromatographic conditions and system applicability test with octadecylsilane bonded silica gel as filler; Acetonitrile 0.085% phosphoric acid solution (17: 83) was used as the mobile phase. The detection wavelength is 316 nm; ; The column temperature is 35℃. The theoretical plate number should be not less than 5000 calculated by ferulic acid peak.
13.7.2.2 preparation of reference substance solution take a proper amount of ferulic acid reference substance, weigh it accurately, put it in a brown volumetric flask, and add 70% methanol to make a solution containing 12μg per 1ml.
13.7.2.3 preparation of test solution take about 0.2g of this product powder (pass through No.3 sieve), weigh it accurately, put it in a conical flask with a stopper, add 20ml of 70% methanol accurately, plug it, weigh it, heat and reflux it for 30 minutes, let it cool, weigh it again, make up the weight loss with 70% methanol, and shake it evenly.
13.7.2.4 determination method accurately absorb 10μl control solution and test solution respectively, inject them into liquid chromatograph, and determine.
The product contains ferulic acid (C 10H 1004) not less than 0.050% in terms of dry product.
13.8 angelica decoction pieces 13.8. 1 processing 13.8. 1 angelica sinensis, removing impurities, washing, moistening thoroughly, slicing, sun drying or low-temperature drying.
This product is round, oval and irregular. The skin is tan to brown. The section is yellowish white or light brown, flat and cracked, with light brown cambium ring in the middle, mostly brown oil spots. Strong aroma, sweet, pungent and slightly bitter.
13.8. 1. 1 identify (except cross section), test and extract the same medicinal materials.
13.8.10.2 take clean slices of angelica sinensis and cook them according to the method of wine decoction (appendix 2 d of Pharmacopoeia I, 20 10).
This product is shaped like angelica tablets. Slices are dark yellow or light brown with slight focal spots. Strong aroma, slightly alcoholic.
The extract of13.8.1.2.1is the same as the medicinal materials, and shall not be less than 50.0%.
The same medicine.
This product is round or irregular, with light brown ring lines on the cross section, elastic, dark yellow and slightly burnt. Sweet, slightly bitter, rich in aroma, with wine aroma. [3]
13.8.2 Sexual taste and sweet, pungent and warm meridian tropism. Liver, heart and spleen meridians entered.
13.8.3 Functions and indications: enriching blood and promoting blood circulation, regulating menstruation and relieving pain, moistening intestines and relaxing bowels. Can be used for treating blood deficiency and sallow, dizziness and palpitation, menoxenia, amenorrhea and dysmenorrhea, abdominal pain due to deficiency of cold, rheumatalgia, traumatic injury, carbuncle swelling and ulceration, intestinal dryness and constipation. Wine, angelica, promoting blood circulation and regulating menstruation. Used for amenorrhea, dysmenorrhea, rheumatalgia, and traumatic injury.
13.8.4 Usage and dosage 6 ~ 12g.
13.8.5 stored in a cool and dry place, protected from moisture and moth.
13.9 source: People's Republic of China (PRC) Pharmacopoeia (20 10).
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