Panda Po (Jack Black) is recognized as the laziest animal in Peace Valley. When a powerful enemy invades the Peace Valley, all the animals in the valley hold a martial arts conference to select a martial arts master to lead everyone to fight against the foreign enemies and defend their homeland. When Po accidentally broke into the martial arts competition, the experts present were shocked to find that this seemingly useless panda was actually the destined "bear" who was about to save the entire Peace Valley!
Dustin Hoffman will lend his voice to Panda Po’s master, a stubborn and rule-abiding kung fu master. The master had to face the headache of Po, an unmotivated student, and train him to become a kung fu master. Apo is also accompanied by the Monkey Master (Jackie Chan), a warrior with great martial arts skills and agility. His mission is to constantly remind Apo of his worthlessness. Po's other master, Master Viper (Lucy Liu), has even more mysterious kung fu: not only can he constantly change his gender, but he can also exert great power in an instant.
Can Apo become a martial arts master and defeat powerful enemies under the guidance of his masters? The future of Peace Valley is still unknown...