Can I draw cartoons with calligraphy ink?

Yes, but I want to ask you if your pen is a comic pen tip or an ordinary pen tip dipped in water. Or just a pen?

if you use the ink for writing calligraphy, it needs to be mixed with water in a proper amount. Moreover, the water needs to be used as soon as possible, and it is easy to have flocs or precipitate impurities in it after a period of time, which affects the fluency of drawing lines.