The main component of Rosuvastatin Calcium Tablets is rosuvastatin, and the pharmacological effects of Rosuvastatin Calcium Tablets are mainly through rosuvastatin. Rosuvastatin is a selective and competitive HMG-CoA reductase inhibitor. HMG-CoA reductase is the rate-limiting enzyme in the conversion of 3-hydroxy-3-methylglutaryl-CoA into mevalonate, the precursor of cholesterol. Rosuvastatin is highly uptaken by the liver and is selective. The liver is the target organ for lowering cholesterol. Moreover, rosuvastatin can increase the number of hepatic LDL receptors on the cell surface, thereby enhancing the uptake and catabolism of LDL, and inhibiting hepatic VLDL synthesis, thereby reducing the total number of VLDL and LDL particles. So,? Rosuvastatin is a selective and competitive HMG-CoA reductase inhibitor. Therefore, rosuvastatin calcium tablets are generally prohibited from being used by the following people in the treatment of primary hypercholesterolemia: 1. Those who are allergic to rosuvastatin or any ingredient in rosuvastatin calcium tablets. 2. Patients with active liver disease, including patients with unexplained persistent elevation of serum aminotransferase and any increase in serum aminotransferase exceeding 3 times the upper limit of normal (ULN). 3. Patients with severe renal impairment (creatinine clearance