"There is no greater sorrow than the death of the heart." From "Zhuangzi?6?1 Tian Zifang".
"There is no greater sorrow than a dead heart." That is, the greatest sorrow is to be depressed and depressed to the point of being unable to extricate yourself.
"There is no greater sorrow than lack of ambition" from "Zhuangzi?6?1 Tian Zifang".
It means that the greatest sorrow is to have no ambition and be so depressed that you cannot extricate yourself. No ambition means no ambition