Chinese alias: 1-(4- fluorophenyl) -(3R)-[3-(4- fluorophenyl) -(3S)- hydroxypropyl ]-(4S)-(4- hydroxyphenyl) -2- propiolactam; Etimibe Yi Zhe Maibu
English name: Ezetimibe
English alias: 1-(4- fluorophenyl) -3-[3-(4- fluorophenyl) -3- hydroxy-propyl ]-4-(4- hydroxyphenyl)-azetidine -2- one; Zetia; ezetimibe ezetimibec 24h 2 1f2n 03
Si Nuo. : 163222-33- 1
Molecular formula: C24H2 1F2NO3.
Molecular weight: 409.43
Density:1.334g/cm3
Melting point: 164- 166℃
Boiling point: 654.9 degrees Celsius at 760 mm Hg.
Flash point: 349.9℃
Steam pressure: 4.83 e-18 mmhg at 25 C.
R36/37/38: Irritating to eyes, respiratory tract and skin.
Hyperlipidemia is one of the high risk factors of coronary heart disease. The drugs for treating hyperlipidemia mainly include cholesterol synthesis inhibitors (such as statins), phenoxyacids (such as fibrates), bile acid chelating agents (such as coleenamine) and others (such as nicotinic acid analogues). Ezetim- ibe is a new cholesterol absorption inhibitor jointly developed by Schering-Plough and Merck. It was approved by FDA in June 2002 under the trade name Zetia. The chemical name is (1- (4- fluorophenyl) -(3R)-[3-(4- fluorophenyl) -(3S)- hydroxypropyl ]-(4s)-(4- hydroxyphenyl) -2- azetidinone), and the molecular formula is c24h21.