Are Li Xin related to Li Si?

There is no family blood relationship but they are all ministers of the Qin State

Li Xin, a famous general of the Qin State at the end of the Warring States Period, (date of birth and death unknown), named Youcheng, Huaili (now Shaanxi) He was born in Xingpingdong, Xianyang [1]. His ancestor Li Zong was a senior official in the Wei State. From Li Xin to Li Xin, he was a minister or general for ten generations. His grandfather Li Chong was the prefect of Longxi in the Qin State and was granted the title of Nanzheng Gong; his father Li Yao was the prefect of Nanjun in the Qin State and was granted the title of Didaohou. He made great contributions in the battle to destroy the Yan Kingdom. Later, he led an army of 200,000 to attack the Chu State. He was victorious at first, but was defeated by the Chu general Xiang Yan. After that, Li Xin's whereabouts were not found in the history books. In addition, Li Xin is the ancestor of Li Guang, the "Flying General" of the Han Dynasty.

Li Si (approximately 284 BC - 208 BC), Li family name, Si, courtesy name Tonggu. At the end of the Warring States Period, he was a native of Shangcai, Chu State (today's Shangcai, Henan Province) [1]. A famous politician, writer and calligrapher in the Qin Dynasty.