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The concepts of essence, qi and spirit in Taoist Neidan originated from pre-Qin philosophy and medicine. I ching said: "essence is a thing, wandering souls are a change, which means knowing the true state of ghosts and gods." It means that delicate gas condenses into a physical shape, and the wandering of gas soul causes change. By investigating the changes of the shapes of things, we can know the true state of ghosts and gods. In ancient philosophy, Zhuangzi Lieyukou used the word "spirit" to describe the life state of "Zhiren". In Zhuangzi, "God" refers to the human mind. Since the Warring States Period, "physicians" have used the concepts of essence and spirit, such as Huang Wen's theory of anger against heaven, the so-called "yin" refers to the viscera containing essence, and "yang" refers to the peripheral tissues that protect the viscera. In Su Wen's view, the zang-fu organs must be peaceful, while the peripheral tissues must be firm and cannot leak. If zang-fu organs and surrounding tissues can't cooperate, essence can't dissipate and survive.