"Being in a high position and indifferent to fame and fortune" means that although a person is in a high position and has power and status, he is not persistent in the pursuit of fame and fortune and can maintain his inner indifference and peace. This attitude embodies a realm of transcending the secular and pursuing spiritual freedom. It is not influenced by power and money, but pays attention to inner cultivation and moral improvement.
"Being in a high position has great responsibilities" means that if a person is in a high position, that is, holding a more important position or role, then his or her responsibilities will be correspondingly great. This sentence emphasizes that people in high positions should be aware of their great responsibilities, always be vigilant, fulfill their tasks dutifully, and never slack off.