2 English reference sinomenine Rhed. Landau Chinese-English dictionary
Sinomenine [Xiangya Medical Dictionary]
Caulis Sinomenii [Xiangya Medical Dictionary]
Sinomenine [Xiangya Medical Dictionary]
Sinomenine [Xiangya Medical Dictionary]
Oriental vine [2 1 century bilingual dictionary of science and technology]
Committee on terminology of traditional Chinese medicine. Terminology of Traditional Chinese Medicine (2004)]
Committee on terminology of traditional Chinese medicine. Terminology of Traditional Chinese Medicine (2004)]
3 Overview Sinomenium Sinomenium is the name of traditional Chinese medicine. See Annals of Traditional Chinese Medicine. It's the dried stem of sinomenine. )Rehd。 Etwils。 And sinomenine. )Rehd。 Etwils。 var。 Cinereum Rehd。 Etwils。 Menispermaceae [1].
Pharmacopoeia of People's Republic of China (PRC) (20 10 edition) records the pharmacopoeia standard of this Chinese medicine.
4 Latin name Sinomenine (La) (Chinese medicine terminology (2004))
5 English name orientvine vine (Chinese Medicine Terminology (2004))
Six synonyms of ivy: ivy, ivy, ivy, ivy [2].
7. sinomenine. )Rehd。 Etwils。 Or ivy. )Rehd。 Etwils。 Var。 The movie Rem Reid. Etwils。 [2].
8 Origin Sinomenine is mainly produced in Hubei, Jiangsu, Zhejiang and other places [2].
9. Sexual taste is bitter, pungent and flat. Liver and spleen meridians [2].
10 efficacy and indications Sinomenium has the functions of expelling wind and dredging collaterals, removing dampness and relieving pain, and can be used for treating rheumatism, joint pain, leg paralysis, itching, edema, beriberi swelling and pain, sciatica and trigeminal neuralgia [2].
Sinomenine 1 1 decoction usage and dosage: 9 ~ 15g [2].
12 chemical constituents of sinomenine The stems and roots of sinomenine contain alkaloids such as Stephanine, Bat Jacky Ge, 8, 14 dihydropapaverine, sinomenine, sinomenine and sinomenine, as well as syringol, β sitosterol and stigmasterol [2
Pharmacological effects of sinomenine 13 sinomenine has analgesic, sedative, antitussive, antihypertensive and anti-inflammatory effects on many animals, but it also has obvious side effects of releasing histamine [2]. Dogs and monkeys often have mild gastrointestinal adverse reactions after oral administration [2].
14 sinomenine pharmacopoeia standard 14. 1 is called sinomenine.
Qingfengteng
Sinomenium sinomenium
14.2 The source of this product is the dried rattan stem of Sinomenine. )Rehd。 Etwils。 And sinomenine. )Rehd。 Etwils。 Var。 The movie Rem Reid. Etwils。 Menispermaceae Cut, bundle or cut into long sections in late autumn and early winter, and dry.
14.3 properties this product is long and cylindrical, often slightly curved, with a length of 20 ~ 70 cm or longer and a diameter of 0.5 ~ 2 cm. The surface is greenish brown to brownish brown, some are grayish brown, with thin longitudinal stripes and lenticels. Nodes are slightly enlarged and branched. Light, hard and brittle, easily broken, uneven section, grayish yellow or grayish brown, thin skin, radial arrangement of wood rays, yellowish white or yellowish brown pulp. Slight breathing and bitterness.
14.4 Identification (1) Cross section of this product: the outermost layer is the thick stratum corneum or cork layer of epidermis. There are scattered fibers and stone cells in the cortex. The fiber bundle of stele sheath is crescent-shaped, and its inner side is often 2 ~ 5 rows of stone cells, which extend tangentially and connect with the stone cell group in radiation to form a ring. External toughness of vascular cambium. The phloem rays gradually widened outward, and conical or branched stone cells could be seen. Most phloem cells are decadent, and some of them have 1 ~ 3 fibers scattered. Xylem vessels are scattered or connected tangentially. The pith cell wall is slightly thicker with obvious pits. The parenchyma cells contain starch granules and calcium oxalate needles.
The powder is yellowish brown or grayish brown. Epidermal cells are yellow or yellow-brown, and the cross section is round or rectangular, with a diameter of 24 ~ 78 microns and covered with stratum corneum. Stone cells are light yellow or yellow, square, spindle, oval or irregular, with thick walls and obvious holes and grooves. The cortical fibers are yellowish or yellow, with a diameter of 27 ~ 70μ m, extremely thick walls and narrow cell cavities. The needle-like crystals of calcium oxalate are fine and exist in thin-walled Burmese cells.
(2) Take 2g of this product powder, add 25ml of ethanol, heat and reflux for 65,438+0h, filter, evaporate the filtrate, and add 65438±0ml of ethanol to dissolve the residue as the test solution. Another sinomenine reference substance was added with ethanol to prepare a solution containing 1mg per 1ml as the reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b), absorb 5μl of the above two solutions, respectively, and spot them on the same silica gel G thin-layer plate, with the upper solution of toluene-ethyl acetate-methanol-water (2: 4: 2: 1) below/kloc-0℃ as the developing agent, and put them in an unfolding cylinder which is pre-saturated with concentrated ammonia solution for 20 minutes. In the chromatogram of the test sample, spots with the same color appear in the position corresponding to the chromatogram of the control sample.
The water content of 14.51shall not exceed 13.0% (appendix ⅸ H first method).
14.5.2 the total ash content shall not exceed 6.0% (appendix ⅸ k).
The content of 14.6 was determined by HPLC (appendix ⅵ d).
14.6. 1 chromatographic conditions and system applicability test with octadecylsilane bonded silica gel as filler; The mobile phase is methanol monophosphate buffer (0.005mol/L disodium hydrogen phosphate solution, 0.005mol/L sodium dihydrogen phosphate to adjust the pH value to 8.0, and then adjust the pH value to 9.0 with 1% triethylamine) (55: 45). The detection wavelength is 262 nm. Calculated by sinomenine peak, the theoretical plate number should not be less than 1500.
14.6.2 preparation of reference substance solution: take an appropriate amount of sinomenine reference substance, weigh it accurately, and add methanol to make a solution containing 0.5mg per 1ml.
14.6.3 preparation of test solution take about 0.5g of this product powder (pass through No.3 sieve), weigh it accurately, put it in a conical flask with a stopper, add 20ml of 70% ethanol accurately, plug it tightly, weigh it, perform ultrasonic treatment (power 250W, frequency 20 khz) for 20 minutes, let it cool, weigh it again, and use 70.
14.6.4 determination method accurately suck 5μl of control solution and 5 μ l of test solution respectively, inject them into liquid chromatograph, and determine them.
This product contains sinomenine (C 19H23NO4) at least 0.50% in terms of dry product.
14.7 sinomenine decoction pieces 14.7. 1 processing to remove impurities, microbubble, moisten thoroughly, cut into thick slices, and dry.
This product is a round thick tablet. The outer surface is green-brown to brown, some are grayish brown, with longitudinal stripes, and some are visible lenticels. The section is grayish yellow to grayish yellow, the bark is narrow, the wood has obvious radial texture, there are many small holes inside, and the pith is yellowish white to brownish yellow. Slight breathing and bitterness.
14.7.2 Check that the water content is the same as that of the medicinal materials, and shall not exceed 9.0%.
14.7.3 Identification of the same medicinal materials (except cross section).
14.7.4 inspection (total ash) is the same as that of medicinal materials.
The content determination of 14.7.5 is the same as that of medicinal materials.
14.7.6 Bitter in nature and taste, pungent, and flat in the channel. Entering the liver and spleen meridians.
14.7.7 Functions and indications: expelling wind and removing dampness, dredging channels and promoting diuresis. Used for rheumatism, joint pain, joint swelling, paralysis and itching.
14.7.8 Usage and dosage 6 ~ 12g.
14.7.9 Store in a dry place.
14.8 Source