2 English reference Guayeju Repanda, Senecio scandens Sham [Landau Chinese-English Dictionary]
Senecio scandens [Xiangya Medical Dictionary]
3. Senecio scandens, a plant of Compositae, is the name of traditional Chinese medicine, which comes from materia medica [1].
climbing groundsel
3. 1 Senecio Senecio alias Senecio Senecio, Senecio, Jiuliming and Yisaoguang [1].
Jiuliming, Huanghuamu, Jiulongguang, Jiulingliang.
3.2 Source and origin of Senecio scandens. Ham, compositae. Distributed in Shaanxi and East China, Central South and Southwest China [1].
3.3 The plant is a perennial herb with woody climbing stems, 1 ~ 5m high, slightly hairy, and then falls off. Leaves alternate, ovate-triangular or elliptic-lanceolate, 4 ~ 12 cm long and 2 ~ 6 cm wide, with tapered apex, wedge-shaped to truncated base, irregularly dentate or microwave-like or nearly entire, and sparse hairs on both sides. Inflorescence terminal, arranged in an umbrella; Involucre tubular, involucre 1 layer; The flowers are yellow, the tongue-shaped flowers are female, and the tubular flowers are bisexual. Achene is cylindrical, with longitudinal grooves, short hair and white crown hair. Autumn and winter to the following spring are the flowering and fruiting periods.
Born on hillsides, under sparse forests, beside forests, roadsides, and grasslands beside ditches. Produced in Jiangsu, Zhejiang, Guangxi and Sichuan.
3.4 Harvest in summer and autumn. At this time, the branches and leaves are lush, the flowers are about to open, and the harvest is dry.
3.5 Bitter taste and cold [1].
3.6 Function: clearing away heat and toxic materials, killing insects and improving eyesight [1].
① Treating upper respiratory tract infection, tonsillitis, pharyngolaryngitis, pneumonia, bacillary dysentery, enteritis, appendicitis, icteric hepatitis, cholecystitis and leptospirosis. Decocting: 15 ~ 30g [1].
② Treating conjunctivitis and keratitis, decocting and making eye drops; Furuncle, acute lymphangitis, erysipelas, decoction and tamping; Eczema, dermatitis, hemorrhoids, fire and water burns, decoction and washing [1].
Senecio scandens is an antipyretic commonly used in ophthalmology, which has the effects of clearing away heat and toxic materials, clearing liver and improving eyesight.
(1) is used for toxic carbuncle and swelling of eye sore, and is compatible with dandelion and chrysanthemum indicum.
(2) It is used for red eyes and swelling caused by excessive fire poison, and is often used with Prunella vulgaris and Chrysanthemum indicum.
(3) External use: It can be made into 10% Senecio Senecio eye drops, which can be used to treat wind-heat, red-eye sky, pepper sore and black-eyed nebula.
3.7 Chemical composition: flavins, chrysanthemums, flavonoids, tannins, alkaloids, etc.
This product contains Senecio scandens, Senecio scandens, hydroquinone, p-hydroxybenzoic acid, vanillic acid, salicylic acid, pyromucic acid, choline and tannin [1].
3.8 pharmacological effects hydroquinone and p-hydroxybenzoic acid have antibacterial effects on influenza Bacillus. The decoction not only has broad-spectrum antibacterial effect on leptospira and trichomonas, but also has anticancer effect [1].
4 Pharmacopoeia Standard of Senecio scandens 4. 1 Name Senecio scandens
climbing groundsel
Climbing Senecio scandens
4.2 Source This product is the dry aboveground part of Radix Cynanchi. Ham. Compositae plants Can be harvested all year round, remove impurities and dry in the shade.
4.3 Characteristics The stem of this product is thin and cylindrical, slightly curved, with branches on the upper part; The surface is gray-green, yellow-brown or purple-brown, with longitudinal edges and densely gray-white pilose. Leaves are alternate, withered and broken. After flattening, the whole leaf is oval-lanceolate or Yangtze Delta-shaped, sometimes with 1 ~ 6 lobes, with irregular serrations at the edge, halberd-shaped or truncated at the base, and villous on both sides. Head flower; Involucre bell-shaped; The flowers are yellow to brown and the crown is white. Slight breathing and bitterness.
4.4( 1) Identification of leaf surface: The vertical peripheral wall of upper epidermal cells is microwave-like or wavy; The cells in the lower epidermis are irregular in shape, and the vertical wall is deeply wavy and curved. Stomatal infinitive or inequality, 3 ~ 6 accessory cells. Non-glandular hair 2 ~ 12 cells, the apical cells are gradually pointed or obtuse and curved, and the cells often contain light yellow oil, with slightly thickened walls and warty processes.
(2) Take 2g of this product powder, add 50ml of anhydrous ethanol containing 0.36% hydrochloric acid, leave it for 65438 0 hours, heat and reflux for 3 hours, let it cool, filter, take 40ml of continuous filtrate, evaporate to dryness, add 25ml of 2% pantothenic acid solution to the residue, filter, add concentrated ammonia solution to the filtrate, and adjust the pH value to10 ~. In addition, 2g of Senecio scandens was taken to prepare a control drug solution in the same way. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia Part I, 20 10), absorb each 10μ l of the above two solutions, spot them on the same silica gel G thin-layer plate, use isopropyl ether-formic acid monohydrate (90: 7: 3) as developing agent, pre-saturate the thin-layer plate for 40 minutes, unfold, take it out and dry it. In the chromatogram of the test sample, the spots with the same color appear at the positions corresponding to the chromatogram of the control medicinal materials.
4.5 Check that the moisture in 4.5. 1 shall not exceed 14.0% (the first method in Appendix VII H of Pharmacopoeia 20 10).
4.5.2 The total ash content shall not exceed 10.0% (Appendix ⅸ K of Pharmacopoeia 20 10).
4.5.3 The acid-insoluble ash content shall not exceed 2.0% (Appendix ⅸ k of Pharmacopoeia I, 20 10).
4.5.4 High performance liquid chromatography-mass spectrometry (Pharmacopoeia 20 10, Appendix ⅸ J) was used to determine p-acetanilide.
4.5.4. 1 chromatographic and mass spectrometry conditions and system applicability test with octadecylsilane bonded silica gel as filler; Using acetonitrile 0.5% formic acid solution (7: 93) as mobile phase; In the positive ion mode of electrospray ionization (ESI), ions with mass-to-charge ratio (m/z) of 366 were selected by a single-stage quadrupole mass spectrometer. The theoretical plate number should be not less than 8000 calculated by Adonivalin base peak.
The output of monocrotaline reference substance was determined by 4.5.4.2 correction factor, accurately weighed, and 0.5% formic acid solution was added to make a solution containing 0.2μg per 1ml as the internal standard solution. Take an appropriate amount of acetanilide reference substance, weigh it accurately, and add 0.5% formic acid solution to make a solution containing 0. 1μg per 1ml as reference substance solution. Accurately measure 2ml of the reference solution, put it in a 5ml volumetric flask, add the internal standard solution Iml accurately, add 0.5% formic acid solution to the scale, shake it evenly, absorb 2μl, and inject it into the liquid chromatography-mass spectrometer to calculate the correction factor.
4.5.4.3 determination method: take about 0.2g of this product powder (pass through No.3 sieve), weigh it accurately, put it in a conical flask with a stopper, add 50ml of 0.5% formic acid solution accurately, weigh it, perform ultrasonic treatment (power 250W, frequency 40 kHz) for 40 min, let it cool, weigh it again, make up the weight loss with 0.5% formic acid solution, shake it evenly, filter it, and measure it accurately. Accurately add 1ml internal standard solution, add 0.5% formic acid solution to the scale, shake well, suck 2ul, and inject it into liquid chromatography-mass spectrometry for determination.
Calculated by dry product, the product contains no more than 0.004% of p-acetanilide (C 18H23NO7).
4.6 The content was determined by high performance liquid chromatography (Appendix ⅵ D of China Pharmacopoeia I, 20 10).
4.6. 1 chromatographic conditions and system applicability test: octadecylsilane bonded silica gel is used as filler; Acetonitrile 0.2% acetic acid solution (18: 82) was used as the mobile phase. The detection wavelength is 360 nm. According to the hyperoside peak, the theoretical plate number should be no less than 8000.
4.6.2 Preparation of reference substance dissolved wave Take a proper amount of hyperoside reference substance, weigh it accurately, and add 75% methanol to make a solution containing 40ug per 1ml.
4.6.3 Preparation of test solution Take the powder of this product (passing through No.2 sieve) about 1g, weigh it accurately, put it in a conical flask with a stopper, add 25ml of 75% methanol accurately, weigh it, heat and reflux it for 65,438 0 hours, let it cool, weigh it again, make up the weight loss with 75% methanol, shake it evenly, filter it, and then weigh it.
4.6.4 Determination method Accurately absorb 20 μ l of control solution and 20μl of test solution respectively, inject them into liquid chromatograph, and determine to obtain the product.
This product contains hyperin (C2 1H200 12) which shall not be less than 0.030% in terms of dry product.
4.7 Sexual taste and channel tropism are bitter and cold. Enter lung meridian and liver meridian.
4.8 Indications: clearing away heat and toxic materials, improving eyesight and promoting diuresis. It can be used for treating carbuncle, sore, common cold, fever, red eyes, swelling and pain, diarrhea and dysentery, and skin eczema.
4.9 Usage and dosage 15 ~ 30g. Appropriate amount for external use, decocted in water and smoked.
4. 10 is stored in a ventilated and dry place [2].
4. 1 1 Source Pharmacopoeia of China 20 10 Edition.
5 Alias of Abalone Senecio is the name of traditional Chinese medicine, which comes from Compendium of Materia Medica. It is an alias of concha Haliotidis recorded in A Bie Lu [1].
5. 1 Source "Compendium of Materia Medica": "Nine-hole snail ("Rihuazi Materia Medica "), the shell name is Senecio scandens. Shi Zhen said: Cassia seed and Senecio scandens are very famous. The nine-hole snail is also named after its shape. "
5.2 Senecio Senecio alias: abalone shell, nine-hole snail, Senecio Senecio [3]
5.3 Source and place of origin Haliotis diversicolor, Haliotis diversicolor, Haliotis diversicolor, Haliotis diversicolor, Haliotis diversicolor, Haliotis diversicolor, Haliotis diversicolor, Haliotis diversicolor, and shells of Haliotis diversicolor. Location: Guangdong, Fujian, Liaoning and Shandong.
5.4 Sexual taste is salty and flat. Into the liver and kidney meridian [3].
5.5 Functions are indicated for calming the liver and suppressing yang, clearing away heat and improving eyesight [3].
1. Treat headache, dizziness and convulsion caused by hypertension. Eye redness and swelling, blurred vision, glaucoma, cataract, tuberculosis fever, hemoptysis and vomiting blood. Decocting: 9 ~ 30g. Crush first and then fry [3].
2. Treat ulcers and traumatic bleeding [3].
5.6 The usage and dosage of Senecio scandens should be calcined, and the affected area should be carefully studied [3].
5.7 Chemical Composition This product mainly contains calcium carbonate [3].
5.8 pharmacological effects of Senecio scandens