2 English reference Ma Ziren Wan [2 1 Century Bilingual Dictionary of Science and Technology]
Maziren Pill [Chinese Medicine Terminology Committee]. Terminology of Traditional Chinese Medicine (2004)]
In Treatise on Febrile Diseases, Ma Zi Ren Wan was recorded. It consists of 500g of hemp seed, 250g of white peony root, 250g of immature bitter orange, 500g of rhubarb, 250g of magnolia officinalis and 250g of almond. It has the functions of moistening intestines, clearing heat, promoting qi circulation and relaxing bowels, and is mainly used for treating spleen deficiency syndrome caused by stomach dryness and heat, spleen and stomach deficiency and cold, and qi stagnation. It is often used to treat habitual constipation, drug constipation and modern constipation.
The prescription in Treatise on Febrile Diseases of Maziren Pill can be said to be a symptomatic treatment for constipation, but its fundamental treatment is to regulate cardiovascular and hemorheological functions, improve the circulation disorder of rectal cushion vein, resist infection and inflammation, improve postpartum infection and laceration of birth canal, and regulate immune function, which is called treating both the symptoms and root causes in traditional Chinese medicine. [ 1]
4. 1 Maziren Pills are alias Maren Pills (Volume 15 of Huojing), Maren Pills with Spleen Rupture (Volume 6 of Taiping Huimin Heji Prescription), Maren Zipi Pills [2] and Spleen Rupture Pills [2].
4.2 The prescription is two liters of Fructus Cannabis, half a catty of Paeonia lactiflora, half a catty of Fructus Aurantii Immaturus (fried), one catty of Radix et Rhizoma Rhei (peeled), one foot of Cortex Magnolia Officinalis (fried, peeled) and one liter of almond (peeled, boiled, without fat) [3].
Two liters of Fructus Cannabis, half a catty of Paeonia lactiflora, half a catty of Fructus Aurantii Immaturus (fried), one catty of rhubarb (peeled), one foot of Magnolia officinalis (fried, peeled) and one liter of almonds (peeled and fried) [2].
500g of seedless seeds, 250g of white peony root, 250g of immature bitter orange (fried), 500g of rhubarb (peeled), 250g of magnolia officinalis (fried and peeled) and 250g of almond (peeled, pointed and boiled without fat).
500 grams of Fructus Cannabis, 250 grams of Paeonia lactiflora, 250 grams of Fructus Aurantii Immaturus, 500 grams of rhubarb, 250 grams of Magnolia officinalis and 250 grams of almonds [4].
20g of hemp seed, 9g of peony, 9g of immature bitter orange, 9g of rhubarb12g, 9g of magnolia officinalis and 9g of almond10g [5].
4.3 The preparation method is the end, and the honey is refined into pills, such as buttonwood [3].
6 flavors are the end, refined honey is the pill, such as the size of a buttonwood tree, each time 10 pill, three times a day, gradually increasing, with softness and easy discharge as the degree. [5]
4.4 Efficacy and Indications Maziren Pill in Treatise on Febrile Diseases has the effects of moistening intestines, clearing away heat, promoting qi circulation and relaxing bowels. Indications: Spleen deficiency syndrome caused by dryness-heat of spleen and stomach, spleen fluid deficiency and qi stagnation, with symptoms of gastrointestinal dryness-heat, body fluid deficiency, constipation, frequent urination, epigastric pain, thirst and bad breath, red tongue with thin yellow fur and rapid pulse [4].
Maziren Pill has the function of moistening intestines and relaxing bowels [2]. Treatment of spleen deficiency, hard stool, frequent urination, yang pulse floating astringent [2].
4.5 The usage and dosage of Hemp Seed Pills are ten capsules three times a day, step by step, with knowledge as the degree [3].
The medicine is ground into powder and honey is refined into pills. 9g each time, 1 ~ 2 times a day, taken with warm water. It can also be decocted, and the dosage is reduced according to the original proportion. [4]
4.6 Fang Jie Ma Zi Wan Ren regarded this syndrome as hypersplenism. It is caused by dryness and heat in the stomach and deficiency of spleen and body fluid. Spleen is the stomach that circulates body fluids. Now the stomach is hot and dry, and the spleen is restrained. Body fluids cannot be distributed four times, but the bladder is lost, so frequent urination occurs; Dryness and heat damage body fluids, and the intestines lose water, so constipation is caused. It is advisable to moisten the intestines, purge heat, promote qi and relax bowels. [6]
Hemp seed is the main medicine in the prescription, which is rich in fat, nourishing spleen and moistening intestines, moistening dryness and relaxing bowels. Rhubarb tastes bitter, cold and hot, and has a laxative effect. Almonds benefit the lungs and reduce qi, moistening dryness and relaxing bowels; Radix Paeoniae Alba nourishes yin and astricts body fluid, softens liver and regulates spleen, and * * * is a minister medicine. Fructus Aurantii Immaturus decomposes qi stagnation, and Cortex Magnolia Officinalis removes fullness, so as to strengthen the power of catharsis. Moisten dryness and smooth intestines with honey, and reconcile various medicines. Throughout the whole prescription, hemp seed is used to tonify the spleen and moisten the intestines, and rhubarb, immature bitter orange and magnolia officinalis are used to treat heat depression, forming a combination of attack and reinforcement. It can make the fu-organs smooth and the body fluid sufficient, and the body fluid in the lower body does not hurt the healthy qi. It is mainly used for spleen hyperactivity due to deficiency of spleen and body fluid and stomach heat. [6]
Maziren Pill is prepared from Xiaochengqi decoction, Fructus Cannabis, almond, Radix Paeoniae Alba and honey. Xiaochengqi decoction is also used to relieve gastrointestinal dryness and heat stagnation, but the actual dosage is very small. Moreover, sesame seeds and almonds, which are moist and fatty foods, can not only nourish yin, moisten dryness and relax bowels, but also slow down the attack of Xiaochengqi decoction so that it does not hurt. Moreover, this prescription only takes 10 pills, and the dose is gradually increasing, which shows that this prescription is a soothing agent. [6]
In the prescription of hemp seed pill, hemp seed is moist and fatty, moistening the intestines and relaxing the bowels; Almonds reduce qi and moisten intestines; Peony nourishes yin and harmonizes; Radix et Rhizoma Rhei, Cortex Magnolia Officinalis, and Fructus Aurantii Immaturus (i.e. Xiaochengqi Decoction) clear away heat and remove stagnation; Honey moistens dryness and smoothes intestines [2]. Combined into pills, it has the function of moistening intestine, relaxing bowels and stopping diarrhea [2]
4.7 Clinical application of Maziren Pill is a common prescription for treating constipation caused by stomach heat and intestinal dryness. Constipation, frequent urination, abdominal distension, abdominal pain, thirst, halitosis, red tongue, thin yellow fur and rapid pulse can be treated with this recipe. [4]
4.7. 1 Add and subtract If you see hemorrhoid bleeding caused by gastrointestinal dryness and heat, add Flos Sophorae Immaturus and Sanguisorba officinalis; For patients with hemorrhoid constipation, Semen Persicae and Radix Angelicae Sinensis are added; Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, etc. If the stool is dry and hard, mirabilite can be added to soften and dissipate the hard stool, purging heat and relaxing bowels. [4]
4.7.2 Pregnant women with contraindications, the elderly and constipation due to blood deficiency and body fluid deficiency should use Maziren Pill with caution [4].
4.8 Modern indications Maziren Pills are often used for habitual constipation, elderly people and postpartum constipation [7].
4.8. 1 Habitual constipation refers to dry stool and difficulty in defecation. The common causes of simple constipation are less food intake and less residue, and digestive juice is absorbed by the intestine; The food composition is unreasonable, protein has more carbohydrates and less, the fermentation effect of intestinal flora on intestinal contents is reduced, and the stool is alkaline; Or there are few vegetables and too little cellulose in the food; In addition, malnutrition or decreased intestinal muscle tension, decreased contractility, slow peristalsis, and easy to cause constipation; Rickets, hypercalcemia, dermatomyositis, dementia, congenital myasthenia, etc. Constipation is often caused by muscle weakness and intestinal wall dysfunction; Anal fissure, * * stenosis, spina bifida or tumor compression ponytail can also cause constipation; Some drugs, such as anticholinergic drugs, antacids, some anticonvulsants, diuretics and iron agents, can also reduce intestinal peristalsis and induce constipation; Irregular life, mental disorder, low immune function and untimely defecation are also common causes of constipation. The same mechanism is that intestinal peristalsis is damaged, intestinal water absorption increases and secretion decreases. [7]
4.8.2 Due to age factors, the elderly with senile constipation have weakened metabolic function, intestinal peristalsis and absorption dysfunction, heart and circulation functions are often blocked, intestinal circulation function is insufficient, and peristalsis and secretion functions can also be limited. Kidney deficiency in the elderly is mainly manifested as insufficient body fluid and functional failure, which is common in senile diseases, especially the elderly who drink less water, are weak and exercise less. [7]
4.8.3 Postpartum constipation is mostly caused by * * and perineal laceration during delivery. If the laceration reaches the third degree, it will damage the external sphincter, and the rectal septum and rectal wall mucosa will be damaged in the fourth degree. It can also be caused by puerperal infection, especially pelvic inflammatory disease and pelvic thrombophlebitis, which will lead to congestion of inferior rectal vein, obstruction of reflux, postpartum fatigue, intestinal peristalsis dysfunction and intestinal absorption. [7]
4.8.4 Pain and bleeding caused by dry stool after other operations are often used to treat * * * diseases, which belong to patients with stomach dryness and insufficient body fluid. [7]
4.9 Pharmacological Effects of Maziren Pills [8]
4.9. 1 Effects on the functions of liver, gallbladder and gastrointestinal tract; the monarch drug, Equus equisetifolia, contains fatty oil, which has the function of moistening intestines. At the same time, fatty acids are produced when the intestine meets alkaline intestinal juice, which enhances intestinal peristalsis. Its alcohol extract has the functions of promoting bile secretion and anti-ulcer. The water extract of Paeonia lactiflora and total glucosides of Paeonia lactiflora have obvious protective effects on liver injury, and at the same time reduce the degeneration and necrosis of hepatocytes and ALT. Paeonia lactiflora has a certain effect on habitual constipation, which can increase mucus secretion of large intestine, promote the propulsion of large intestine and small intestine, and increase the water content of large intestine and small intestine. The main diarrhea-inducing components of rhubarb are sennoside, aloe-emodin and rhein. Sennoside is converted into rhein anthrone by intestinal bacteria, which acts on the middle and distal colon, increasing tension, strengthening exercise and inhibiting the absorption of Na+ and water. At the same time, the three components of rhubarb also inhibit the absorption of glucose by small intestine and colon, and directly enhance the electrical excitability of intestinal smooth muscle cells, thus promoting intestinal peristalsis, increasing intestinal volume, discharging loose stool, and the effect of emodin on intestinal tract. Rhubarb has obvious protective effect on liver injury, which can reduce the swelling, necrosis and degeneration of liver cells and reduce ALT. Rhubarb can promote RNA synthesis of hepatocytes, liver regeneration, blood circulation of liver, dredge capillary bile duct, relax sphincter of bile duct, promote gallbladder contraction and promote bile secretion. At the same time, it inhibits gastric acid secretion, promotes PGE production in gastric mucosa and enhances the barrier function of gastric mucosa, thus having anti-ulcer effect. Houpu decoction stimulates the intestine in a large dose and inhibits the intestine in a small dose. Amygdalin can promote the proliferation of hepatocytes, and the water-soluble part of almond can inhibit the increase of ALT and AST, which has the function of lubricating and relaxing bowels. The auxiliary medicine Fructus Aurantii Immaturus can increase the rhythm of intestinal contraction, not only excite gastrointestinal tract, enhance peristalsis, but also reduce the tension of intestinal smooth muscle, which has spasmolytic effect. At high concentration, Fructus Aurantii Immaturus has inhibitory effect on intestinal smooth muscle, and at low concentration, it shows excitatory effect after short-term inhibition. When pathological sexual function is hyperactive, such as intestinal spasm and diarrhea, it shows inhibitory effect, which can relieve spasm, diarrhea and pain; But when the function is low, such as bloating, gastroptosis, gastrointestinal weakness, intestinal obstruction, etc., it is exciting. This biphasic regulation can effectively regulate gastrointestinal dysfunction and restore gastrointestinal movement to normal. At the same time, the hot water extract of Fructus Aurantii Immaturus and its volatile oil can significantly reduce gastric juice secretion and pepsin activity, and have anti-ulcer effect. Magnolol contained in Magnolia Officinalis as adjuvant has anti-hepatitis virus effect, which can reduce the substantial pathological damage such as degeneration and necrosis of hepatocytes, reduce ALT, obviously prevent the formation of liver fibrosis and cirrhosis, improve the activity of SOD in plasma of immune liver fibrosis and reduce the content of LPO. Houpu decoction can inhibit hypersecretion of gastric acid and has anti-ulcer effect; Volatile oil from Magnolia officinalis can reflect and increase the secretion of digestive gland; Houpu decoction has an exciting effect on gastrointestinal smooth muscle. Honey can promote liver cell regeneration, has anti-ulcer effect, can obviously promote intestinal propulsion, and reflexively inhibit gastric juice secretion.
It can be seen that this prescription has the functions of protecting liver, resisting cirrhosis and ulcer, especially promoting gastrointestinal movement and facilitating defecation.
4.9.2 Effects on heart, circulatory system and hemorheology. The monarch drug Sagittarius can lower blood pressure, prolong coagulation time and inhibit thrombosis. Radix Paeoniae Alba extract and total glucosides of Radix Paeoniae Alba have protective effects on myocardial ischemia. Paeonia lactiflora can dilate blood vessels, coronary arteries, increase myocardial nutritional blood flow, increase myocardial contractility, resist myocardial ischemia caused by pituitrin, inhibit platelet aggregation caused by ADP and arachidonic acid, reduce the wet weight of platelet thrombosis, and have antithrombotic effect. Rhubarb has a short-term hypotensive effect by inhibiting angiotensin converting enzyme, and has a blood lipid/phospholipid ratio and cholesterol lowering effect on hypercholesterolemia. It has obvious hemostatic effect on internal bleeding and external bleeding, shortens coagulation time, reduces capillary permeability and promotes platelet production; Rhubarb can inhibit Ca2+ influx and platelet aggregation. Rhubarb can improve hemorheology, inhibit Na+K+ATPase activity of cell membrane, increase plasma osmotic pressure and dilute blood, thus reducing blood viscosity and improving microcirculation disturbance. Rhubarb also has cardiotonic effect. Trace element chromium contained in almonds can reduce cholesterol deposition and inhibit arteriosclerosis, and unsaturated fatty acids contained in almonds can also reduce blood lipids. The auxiliary material Fructus Aurantii Immaturus injection can excite the heart, enhance myocardial contractility, increase cardiac output, significantly reduce coronary resistance, increase coronary blood flow, reduce myocardial oxygen consumption, improve myocardial metabolism, and at the same time have the effects of boosting blood pressure and resisting shock. Magnolin or magnolol contained in Magnolia officinalis can lower blood pressure, and magnolol can inhibit platelet aggregation by inhibiting the production of thromboxane A2(TXA2) and intracellular calcium transport. Honey can lower blood pressure, dilate coronary artery, increase coronary blood flow, increase myocardial contractility, and has a cardiotonic effect. It can be seen that this prescription can not only enhance myocardial function and improve coronary blood supply, but also improve hemorheology and prevent thrombosis. Most of its effects on blood pressure are hypotensive, and only Fructus Aurantii Immaturus can boost blood pressure, which can also prevent blood pressure from dropping too much, which is beneficial to improve constipation caused by circulatory disorder in the elderly and pregnant women.
4.9.3 Anti-pathogenic microorganism effect This prescription has anti-pathogenic microorganism effect except hemp seed. Shaoyao gancao decoction has inhibitory effect on a variety of pathogenic bacteria, with strong antibacterial power and wide antibacterial spectrum. It can inhibit staphylococcus aureus, hemolytic streptococcus, green streptococcus, streptococcus pneumoniae, typhoid and paratyphoid bacilli, Shigella, staphylococcus, Escherichia coli, Pseudomonas aeruginosa and some fungi such as Trichophyton purpurea, Trichophyton concentric, Epidermophyton rubrum, Nocardia stellata and Microsporum wool, and has direct antiviral effect. Rhubarb also has inhibitory effect on most Gram-positive bacteria and Gram-negative bacteria, except for some of the above bacteria, it is sensitive to hemolytic streptococcus, Neisseria gonorrhoeae, diphtheria, Bacillus subtilis, anthrax and typhoid, and has inhibitory effect on Bacteroides fragilis, most fungi, Helicobacter pylori, influenza virus, cytomegalovirus, herpes simplex virus, coxsackie virus and hepatitis B virus, as well as amoeba and trichomonas. Almond oil can inhibit ascaris lumbricoides, hookworm, typhoid fever and paratyphoid Bacillus. Naringin and hesperidin contained in Fructus Aurantii Immaturus have inhibitory effects on most of the above bacteria and have antiviral effects, especially on HIV virus. Magnolia officinalis decoction and magnolol contained in it have broad-spectrum antibacterial effect. Except for most of the above bacteria, it has obvious antibacterial effect on Gram-positive bacteria, acid-fast bacteria, pneumococcus, Staphylococcus aureus, common pathogenic skin fungi and dental caries bacteria, and has antiviral effect, especially on hepatitis virus. Honey has inhibitory effect on most of the above bacteria, such as low concentration bacteriostasis and high concentration sterilization, in addition to mycobacterium tuberculosis and Brucella. This is especially important for constipation caused by various infectious diseases caused by maternal and puerperal fever. It can also prevent and treat infectious diseases caused by decreased immune function of the elderly.
4.9.4 Influence on immune function The official drug Radix Paeoniae Alba has biphasic regulation on various immune responses. First, total glucosides of paeony have a biphasic regulation effect on humoral immunity by regulating TH and TS, thus maintaining the normal level of antibodies in vivo; At the same time, it has a negative regulatory effect on b cells by promoting the release of PGE2 from macrophages; Total glucosides of paeony have a biphasic regulatory effect on T cell function in a function and concentration-dependent manner, which can promote the induction of specific and nonspecific regulatory cells. Total glucosides of paeony also have two-way regulation on macrophages, which can induce interferon and activate reticuloendothelial system. Rhubarb can protect bone marrow cells from immunosuppressive agents, and emodin can activate monocytes to secrete IL-2 and IFNγ-γ by cooperating with phytohemagglutinin, so it has immune enhancement effect. Rhubarb can exert various immunomodulatory effects on intestinal mucosal cells and brain cells. Amygdalin can obviously promote the functions of Kupffer cells, lung macrophages and peritoneal macrophages, and at the same time, amygdalin can obviously promote the proliferation of mitogen on spleen T lymphocytes and enhance the activity of spleen NK cells. At the same time, it promotes the T lymphocyte transformation of PHA. The water extract of Fructus Aurantii Immaturus and its hesperidin and hesperidin can inhibit the release of histamine from mast cells induced by compound 48/80, and hesperidin can inhibit type I allergic reaction. Magnolia officinalis can also effectively improve the body's immune function, improve the body's cellular immune function, and has anti-allergic effect. Honey can enhance humoral immune function and increase the number of antibody-secreting cells. It can be seen that this prescription can make the immune function of the body reach normal through immune promotion and biphasic regulation, which is especially important for the elderly and parturient.
4.9.5 Anti-inflammatory, antioxidant and antiallergic effects The alcohol extract of Fructus Cannabis has the effects of inhibiting the increase of inflammatory capillary permeability, eliminating edema and relieving pain. Paeoniflorin and paeonol contained in Paeonia lactiflora have obvious anti-inflammatory effect, and have obvious inhibitory effect on various experimental nonspecific inflammation and immune inflammation, which reduces capillary permeability, improves exudation, edema and proliferation; At the same time, the total glycosides of Paeonia lactiflora and Paeonia suffruticosa can scavenge oxygen free radicals and hydroxyl free radicals, enhance the activities of SOD and GSHPx, reduce the levels of MDA, NO and TNF, and inhibit the excessive secretion of IL 1 and PGE2, so they have antioxidant effects. Linoside isolated from rhubarb has the same anti-inflammatory activity as aspirin. Emodin can reduce the synthesis and release of leukotriene B4 and 5- hydroxy eicosapentaenoic acid, activate monocytes to secrete TNFα, IL 1, IL6 and IL8, inhibit the secretion of these factors induced by endotoxin, and cooperate with PHA to activate monocytes to secrete IL2 and INF γ. Rhubarb can also scavenge oxygen free radicals, H2O2 and other reactive oxygen species, inhibit lipid peroxidation, and show anti-inflammatory effect. Emodin has a good antagonistic effect on early exudation of inflammation, increased capillary permeability and leukocyte migration. Rhubarb decoction has obvious inhibitory effect on acute inflammatory exudative edema. Almond also has anti-inflammatory effect, and pepsin hydrolysate of bitter almond has obvious inhibitory effect on inflammatory edema and granulation tissue proliferation. Hesperidin and naringin contained in Fructus Aurantii Immaturus have vitamin P-like activity, which can reduce capillary permeability and brittleness, thus reducing inflammatory exudation. Naringin and hesperidin have a certain inhibitory effect on non-enzymatic peroxidation and MDA production, and hesperidin also has a strong scavenging effect on oxygen free radicals. Magnolia officinalis can inhibit both type ⅰ and type ⅳ allergic reactions. These effects have therapeutic effects on parturients, especially those with laceration and pelvic inflammatory disease, thus eliminating these causes and relieving constipation.
4. 10 Song Fang Ma Ziren Pill for spleen, rhubarb Shaoxing, Park Chi; [4]
4. 165438+
5 drug description of Maziren Pill 5. 1 drug name Maziren Pill
5.2 classification of digestive system drugs >: Chinese patent medicine
5.3 honey pill dosage form, each pill weighs about 9 grams. Each box contains 10 pills.
5.4 The main components of Maziren Pill are Fructus Cannabis, Radix Paeoniae Alba, Semen Armeniacae Amarum, Fructus Aurantii Immaturus, Cortex Magnolia Officinalis and Radix et Rhizoma Rhei.
5.5 Pharmacological Effects of Hemp Seed Pills Hemp seed and almond contain fatty oil active substances, which can strengthen intestinal peristalsis and obviously moisten intestines. Rhubarb contains anthraquinones, which can enhance the peristalsis of large intestine and induce diarrhea. It has antibacterial effect on dysentery bacillus, Escherichia coli, Pseudomonas aeruginosa, streptococcus, pneumococcus and dermatophytes. Paeonia lactiflora mainly contains paeoniflorin, which has the functions of spasmolysis, sedation, analgesia, increasing peripheral white blood cells and improving lymphocyte transformation rate. Magnolia officinalis not only has exciting effect on intestinal smooth muscle, but also has antibacterial effect, and has obvious inhibitory effect on staphylococcus aureus, pneumococcus and Shigella dysenteriae. Fructus Aurantii Immaturus can strengthen the contraction rhythm of gastrointestinal movement.
5.6 The main functions of Maziren Pill are moistening intestines, clearing away heat, promoting qi circulation and relaxing bowels. Indications: gastrointestinal dryness and heat, spleen deficiency and constipation. Symptoms include dry stool, frequent urination, red face and fever, abdominal distension and abdominal pain, dry mouth and bad breath, red or yellow tongue coating and slippery pulse. It is suitable for treating constipation caused by intestinal dryness, habitual constipation, postoperative constipation and ascaris intestinal obstruction. Malnutrition and the elderly.
5.7 Usage and dosage of Hemp Seed Pill: 1 ~ 2 times, daily 1 time, 9g each time, taken with warm water.
5.8 Precautions: Patients should use it with caution.
5.9 Expert comments 1. Hemp seed and almond contain fatty oil active substances, which can strengthen intestinal peristalsis and moisten intestines obviously. Rhubarb contains anthraquinones, which can enhance the peristalsis of large intestine and induce diarrhea. It has antibacterial effect on dysentery bacillus, Escherichia coli, Pseudomonas aeruginosa, streptococcus, pneumococcus and dermatophytes. Paeonia lactiflora mainly contains paeoniflorin, which has the functions of spasmolysis, sedation, analgesia, increasing peripheral white blood cells and improving lymphocyte transformation rate. Magnolia officinalis not only has exciting effect on intestinal smooth muscle, but also has antibacterial effect, and has obvious inhibitory effect on staphylococcus aureus, pneumococcus and Shigella dysenteriae. Fructus Aurantii Immaturus can strengthen the contraction rhythm of gastrointestinal movement. Therefore, it is mainly used to treat constipation caused by intestinal dryness and stagnation in clinic. Old people and postpartum diseases such as intestinal dryness, constipation, habitual constipation, etc.
2. Clinical application: used to treat constipation due to intestinal dryness, habitual constipation, postoperative constipation, ascaris intestinal obstruction, etc. (1) Clinical observation: 47 cases of ascaris intestinal obstruction were treated with Maziren Pill plus Mume, Areca catechu and Pericarpium Citri Tangerinae, and the effective rate was 100%: (2) 500 cases of postoperative defecation difficulty were treated with Maziren Pill, and the effective rate was 95.8%; (3) The 74-year-old woman who had been treated for 20 years was cured of intractable constipation.
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