Introduction to Ginseng Yangrong Pills

Contents 1 Pinyin 2 English Reference 3 Overview 4 "Taiping Huimin Heji Bureau Prescription" Volume Five Ginseng Yangrong Pills 4.1 Prescription 4.2 Preparation method 4.3 Usage and dosage of Ginseng Yangrong Pills 4.4 Functions and Indications 4.5 Compatibility 4.6 Pharmacological effects of Ginseng Yangrong Pills 5 Ginseng Yangrong Pills in Volume 12 of "Bao Ming Ge Kuo" 5.1 Composition 5.2 Indications 5.3 Usage and dosage of Ginseng Yangrong Pills 5.4 Addition and subtraction 5.5 Preparation method 6 Pharmacopoeia standard of Ginseng Yangrong Pills 6.1 Product name 6.2 Prescription 6.3 Preparation method 6.4 Properties 6.5 Identification 6.6 Inspection 6.7 Content determination 6.7.1 Chromatographic conditions and system suitability test 6.7.2 Preparation of reference solution 6.7.3 Preparation of test solution 6.7.4 Determination method 6.8 Function and Indications 6.9 Usage and Dosage 6.10 Specifications 6.11 Storage 6.12 Version 7 Ginseng Yangrong Pills Drug Instructions 7.1 Drug Name 7.2 Drug Chinese Pinyin 7.3 Dosage Form 7.4 Properties 7.5 Main Ingredients of Ginseng Yangrong Pills 7.6 Functions and Indications of Ginseng Yangrong Pills 7.7 Ginseng Yangrong Pills Usage and dosage of pills 7.8 Precautions 7.9 Interactions between Ginseng Yangrong Pills and other drugs 7.10 Remarks 8 References attached: 1 Ginseng Yangrong Pills in ancient books* Other versions of related drug instructions for Ginseng Yangrong Pills 1 Pinyin

Ginseng Bolus for Tonification [Xiangya Medical Professional Dictionary]

renshen yangrong pills [Traditional Chinese Medicine Terminology Approval Committee. Traditional Chinese Medicine Terminology (2004) )]

renshen yangrong wan [Traditional Chinese Medicine Terminology Approval Committee. Traditional Chinese Medicine Terminology (2004)] 3 Overview

Ginseng Yangrong Pill is the name of a prescription, and there are about two prescriptions with the same name. . The main ingredients are ginseng, Atractylodes (soil-fried), Poria, roasted licorice, angelica, cooked rehmannia root, white peony root (bran stir-fried), roasted astragalus, tangerine peel, polygala root (prepared), cinnamon, Schisandra chinensis (wine steamed), fresh ginger, dahi Jujube[1]. It has the effect of warming and tonifying qi and blood. It is used for insufficiency of heart and spleen, deficiency of qi and blood, thin body and mental fatigue, less food and loose stools, and weakness after illness.

"The Pharmacopoeia of the People's Republic of China" (2010 edition) records the pharmacopoeial standards of ginseng Yangrong Pills, a Chinese patent medicine. 4 Ginseng Yangrong Pills in Volume Five of "Taiping Huimin Heji Bureau Prescriptions"

Ginseng Yangrong Pills is the name of the prescription, which is a honey pill made from ginseng Yangrong decoction. It comes from "Taiping Huimin Heji Bureau" Bureau Prescription" Volume Five. Ginseng Yangrong Decoction is also known as Yangying Decoction and Yangrong Decoction [2]. 4.1 Prescription

Three liang of white peony root, one liang each of angelica root, tangerine peel, astragalus, cassia root, ginseng, simmered atractylodes, and roasted licorice, seven and a half qian each of rehmannia glutinosa, schisandra chinensis, and poria cocos, polygala root (fried, removed Heart) half two [2]. 4.2 Preparation method

It is a coarse powder [2] 4.3 Usage and dosage of Ginseng Yangrong Pills

Take four qian per serving, add three slices of ginger, two jujubes, decoct in water and take it [2 ]. 4.4 Functions and Indications

Replenishing qi and blood, nourishing the heart and calming the mind. Treats fatigue due to overwork, sluggish limbs, shortness of breath, shortness of breath, shortness of breath, tightness in the lower abdomen, strong pain in the lower back, palpitations, dry throat, dry lips, tasteless food, weak yin and yang, excessive sadness, excessive lying down and infrequent rising, prolonged It lasts for years, sometimes as little as a hundred days, and gradually becomes emaciated, and the five internal organs are exhausted and difficult to revive. It also treats symptoms such as deficiency of the lungs and large intestine, cough and diarrhea, shortness of breath, vomiting, and phlegm and saliva [2]. 4.5 Compatibility

If there is nocturnal emission or spermatorrhea, add one or two keels; for cough, add donkey hide gelatin [2]. 4.6 Pharmacological effects

Experimental research: This prescription can significantly increase the leukocytes in the peripheral blood of experimental animals and increase the level of colony-forming factor (CSF) in their serum [2]. 5 Ginseng Yangrong Pills 5.1 in Volume 12 of "Guo Ming Ge Kuo" Composition

1 half of Atractylodes macrocephala, 1 half of Zhiqi, 1 half of white peony root, 1 half of Polygala root (boiled licorice) , 2 liang of angelica root, 2 liang of yam, 2 liang of cooked rehmannia glutinosa, 2 liang of Wuwei, 2 liang of ginseng, 2 liang of white poria, 5 qian of cornus meat, 5 qian of raw rehmannia glutinosa, 8 qian of tangerine peel (washed).

5.2 Indications

Ginseng Yangrong Pills in Volume 12 of "Bao Ming Ge Kuo" is mainly used to treat men and women with Qi and blood deficiency, lack of energy, insufficient spleen and stomach, and thin body. 5.3 Usage and dosage of Ginseng Yangrong Pills

Take 80 pills per serving, with salt soup; in the cold months, salt and wine. 5.4 Addition and subtraction

For cough, add 1 tael each of Ophiopogon japonicus, Fritillaria, aster, and winter flowers; for heat, add 1 tael each of Phellodendron and Anemarrhena; for spermatorrhea and turbidity, add 1 tael of oysters and 5 keels. Money; vomiting bloody nose, add 2 taels each of paeoniae gall bark and red peony root. 5.5 Preparation method

The above is fine powder, use 1 duck, take blood, add honey to refine, mix with medicine to make pills, as big as sycamore seeds. 6 Pharmacopoeia Standards of Renshen Yangrong Wan 6.1 Product Name

Renshen Yangrong Wan

Renshen Yangrong Wan 6.2 Prescription

Ginseng 100g, Tubaizhu 100g, Poria 75g, 100g of roasted licorice, 100g of angelica, 75g of cooked rehmannia, 100g of white peony root (stir-fried with bran), 100g of roasted astragalus, 100g of tangerine peel, 50g of polygala root, 100g of cinnamon, 75g of Schisandra chinensis (steamed with wine) 6.3 Preparation method

Above Crush the twelve flavors into fine powder, sieve and mix well. Take another 50g of ginger and 100g of jujube, add water in batches and boil until the flavor is gone, filter, and concentrate the filtrate to a clear paste with a relative density of 1.25 (80°C). For every 100g of powder, add 35-50g of refined honey, mix with ginger and jujube liquid, make pills, and dry to make water honey pills; or add 90-100g of refined honey, mix well with ginger and jujube liquid, and make honey pills. . 6.4 Properties

This product is a brown water honey pill or a large honey pill; it tastes sweet and slightly pungent. 6.5 Identification

(1) Take this product and observe it under a microscope: the irregular branched clumps are colorless and dissolve when exposed to chloral hydrate test solution; the hyphae are colorless or light brown (Poria cocos). Calcium oxalate cluster crystals have a diameter of 20 to 68 μm and sharp edges and corners (ginseng). The stone cells are round or rectangular, with a diameter of 32-88 μm and a thin wall (cinnamon) on one side. The fibers are bundled or scattered, the wall is thick, there are longitudinal cracks on the surface, and the two ends are broken into broom-like or flat sections (burned astragalus). The parenchyma cells surrounding the fiber bundle contain calcium oxalate square crystals, forming crystal fibers (Glycyrrhiza uralensis). The seed coat stone cells are light yellow or light yellow brown, with a polygonal surface, thick walls, fine pores and grooves, and a dark brown substance (Schisandra chinensis) in the cell cavity. Calcium oxalate cluster crystals have a diameter of 18 to 32 μm and are found in parenchyma cells, often arranged in rows, or one cell contains several cluster crystals (white peony root). The parenchyma cells are brown to dark brown, and the cells are mostly shriveled and contain brown nuclei (rehmannia glutinosa). Calcium oxalate needle crystals are small, 10 to 32 μm long, and are irregularly filled in parenchyma cells (Tubai Zhu). The thin-walled cells are spindle-shaped, with slightly thick walls and extremely fine diagonal staggered textures (Angelica sinensis). Calcium oxalate square crystals are present in parenchyma tissue (tangerine peel). The surface of cork cells is polygonal, almost square or almost rectangular, with thin vertical walls, pits and intermittent shapes (Polygala).

(2) Take 18g of this product, cut into pieces, add 10g of diatomaceous earth, grind evenly, fully grind and extract with 7% sulfuric acid solution 3 times (100ml, 50ml, 50ml), centrifuge, and take acid water liquid, heat and reflux for 1 hour, let cool, shake and extract with petroleum ether (30~60℃) three times, 50ml each time, combine the petroleum ether liquid, evaporate to dryness, add 0.5ml of absolute ethanol to the residue to dissolve, and use it as a test product solution. Take another reference substance of ginsengdiol and ginsenotriol and add absolute ethanol respectively to make a solution containing 1mg per 1ml as the reference solution. According to the thin layer chromatography (Appendix VI B of Pharmacopoeia 2010 edition) test, take 10 μl of the test solution and 5 μl of the reference solution, respectively, and spot them on the same silica gel G thin layer plate. Use diethyl ether-chloroform (1: 1) Use the developing agent, unfold it, take it out, dry it, spray it with 10% sulfuric acid ethanol solution, heat it at 105℃ until the spots are clearly colored, and inspect it under an ultraviolet light (365nm). In the chromatogram of the test product, fluorescent spots of the same color appear at the positions corresponding to the chromatogram of the reference substance.

(3) Take 9g of this product, cut into pieces, add 9g of diatomaceous earth, grind evenly, put it in a Soxhlet extractor, add an appropriate amount of methanol, heat and reflux to extract until the extract is colorless, and the extract is evaporated. Dry, add 30 ml of water to the residue to dissolve, shake and extract with water-saturated n-butanol three times, 20 ml each time, combine the n-butanol extracts, wash with 20 ml of water, discard the water washings, evaporate the n-butanol liquid to about 1 ml, add 2g of neutral alumina, mix well in a water bath, dry, add to the neutral alumina column (200 mesh, 2g, inner diameter 1~1.5cm), use 50ml of ethyl acetate-methanol (1:1) mixed solution Elute, collect the eluate, evaporate to dryness, add 1 ml of ethanol to the residue to dissolve, and use the supernatant as the test solution. Take another paeoniflorin reference substance, add ethanol to make a solution containing 1mg per 1ml, and use it as the reference substance solution.

According to the thin layer chromatography (Appendix VI B of the 2010 edition of the Pharmacopoeia), take 10 μl of the test solution and 5 μl of the reference solution, respectively point them on the same silica gel G thin layer plate, and use chloroform-ethyl acetate-methanol. - Formic acid (40:5:10:0.2) is used as the developing agent, unfold, take out, dry, spray with 10% sulfuric acid ethanol solution, and heat at 105°C until the spots are clearly colored. In the chromatogram of the test product, spots of the same color appear at the positions corresponding to the chromatogram of the reference substance.

(4) Take 9g of this product, cut it into pieces, put it in a round-bottomed flask, add 200ml of water, and test according to the volatile oil determination method (Appendix Until the graduated part overflows into the flask, add 2 ml of ethyl acetate, heat and reflux for 1 hour, separate the ethyl acetate layer, concentrate to about 0.25 ml, and use it as the test solution. Take another 0.5g of Angelica sinensis control medicinal material and prepare the reference medicinal material solution in the same way. Then take the cinnamic aldehyde reference substance and add ethyl acetate to make a solution containing 1μl per 1ml as the reference substance solution. According to the thin layer chromatography (Appendix VI B of Pharmacopoeia 2010 Edition) test, absorb 2 to 6 μl of the test solution, 2 μl of the control medicinal solution and the reference solution, respectively, and spot them on the same silica gel G thin layer plate, and use n-hexane to -Ethyl acetate (9:1) is used as the developing agent, unfold, take out, dry, and inspect under ultraviolet light (365nm). In the chromatogram of the test product, fluorescent spots of the same color appear at the positions corresponding to the chromatogram of the Angelica sinensis control medicinal material; spray dinitrophenylhydrazine ethanol test solution, heat until the spots are clearly colored, examine under sunlight, and compare with cinnamaldehyde At the corresponding position of the reference substance chromatogram, spots of the same color appear.

(5) Take 9g of this product, cut into pieces, add 4.5g of diatomaceous earth, add 50ml of water, grind evenly, centrifuge, discard the supernatant, add 50ml of water to the residue, repeat the same process twice. , dry at 50℃ for 3 hours, put it in a Soxhlet extractor, add 80ml of petroleum ether (60~90℃), put it on a water bath and heat to reflux for 1 hour, discard the petroleum ether, evaporate the residue, add 80ml of methanol, and put it in a water bath Heat and reflux until the extract is colorless, let cool, filter, and concentrate the filtrate to about 1 ml, which is used as the test solution. Take another 0.5g of tangerine peel control medicinal material, add 5 ml of methanol, ultrasonicate for 5 minutes, filter, and the filtrate is used as the control medicinal material solution. Then take the hesperidin reference substance and add methanol to make a saturated solution, which is used as the reference substance solution. According to the thin layer chromatography (Appendix VI B of the 2010 edition of the Pharmacopoeia) test, absorb 0.5 μl of each of the above three solutions, and place them on the same silica gel G thin layer plate prepared with 0.5% sodium hydroxide solution. Use ethyl ester-methanol-water (100:17:13) as the developing agent, spread it to about 3cm, take it out and dry it; then use the upper layer solution of toluene-ethyl acetate-formic acid-water (20:10:1:1) As a developing agent, unfold it to a spreading distance of about 8cm, take it out, dry it, spray it with aluminum trichloride test solution, and inspect it under a UV lamp (365nm). In the chromatogram of the test product, fluorescent spots of the same color appear at positions corresponding to the chromatogram of the control medicinal material and the chromatogram of the reference substance. 6.6 Inspection

It should comply with the relevant regulations under pills (Appendix I A of the 2010 edition of the Pharmacopoeia). 6.7 Content determination

Determine according to high performance liquid chromatography (2010 edition of Pharmacopoeia, Appendix VI D). 6.7.1 Chromatographic conditions and system suitability test

Use octadecylsilane bonded silica gel as the filler; use methanol-0.11% acetic acid solution (40:60) as the mobile phase; the detection wavelength is 283nm . The number of theoretical plates should not be less than 2000 based on the hesperidin peak. 6.7.2 Preparation of reference substance solution

Take an appropriate amount of hesperidin reference substance, weigh it accurately, and add methanol to make a solution containing 30 μg per 1 ml. 6.7.3 Preparation of the test solution

Take an appropriate amount of water honey pills of this product, grind it, take about 0.8g, and weigh it accurately; or take the large honey pills under the weight difference item, cut into pieces, and mix Evenly, take about 1g, weigh it accurately, put it in a stoppered Erlenmeyer flask, add 50ml of methanol accurately, stop it tightly, weigh it, ultrasonic treatment (power 250W, frequency 33kHz) for 1 hour, let it cool, and weigh it again. Use methanol to make up for the lost weight, shake well, filter, and take the remaining filtrate to get it. 6.7.4 Determination method

Precisely draw 10 μl of the reference solution and 5 to 10 μl of the test solution, inject them into the liquid chromatograph, and measure.

This product contains tangerine peel. Calculated as hesperidin (C28H34O15), every 1g of Shuimi Pills should not be less than 2.0mg; each pill of Damei Pills should not be less than 13mg. 6.8 Functions and indications

Warm and nourish qi and blood. It is used for insufficiency of heart and spleen, deficiency of qi and blood, thin body and mental fatigue, less food and loose stools, and weakness after illness. 6.9 Usage and dosage

Take orally. Water honey pills are 6g at a time, and big honey pills are 1 pill at a time, 1 to 2 times a day. 6.10 Specifications

Each pill of Dami Pills weighs 9g. 6.11 Storage

Sealed.

6.12 version

"The Pharmacopoeia of the People's Republic of China" 2010 Edition 7 Ginseng Yangrong Pills Drug Instructions 7.1 Drug Name

Ginseng Yangrong Pills 7.2 Drug Chinese Pinyin

Renshen Yangrong Wan 7.3 Dosage Form

Each pill of Dami Pills weighs 9g 7.4 Properties

Renshen Yangrong Wan is a brown water honey pill or Dami Pill; it tastes sweet and slightly pungent. 7.5 The main ingredients of Ginseng Yangrong Pills

Ginseng, Atractylodes, Angelicae Sinensis, Astragalus, cinnamon, tangerine peel, white peony root, Poria cocos, Rehmannia glutinosa, Schisandra chinensis, licorice, etc. 7.6 Functions and Indications of Ginseng Yangrong Pills

Warming and nourishing qi and blood. It is used for insufficiency of heart and spleen, deficiency of qi and blood, thin body and mental fatigue, less food and loose stools, and weakness after illness. 7.7 Usage and dosage of Ginseng Yangrong Pills

Take orally. Water honey pills are 6g at a time, and big honey pills are 1 pill at a time, 1 to 2 times a day. 7.8 Precautions

1. Avoid foods that are difficult to digest.

2. Patients with colds and fever should not take it.

3. People with serious chronic diseases such as high blood pressure, heart disease, liver disease, diabetes, and kidney disease should take it under the guidance of a physician.

4. Children, pregnant women, and lactating women should take it under the guidance of a physician.

5. If the symptoms are not relieved after taking the medicine for 4 weeks, you should go to the hospital for treatment.

6. People who are allergic to Ginseng Yangrong Pills should not use it, and those with allergies should use it with caution.

7. It is prohibited to use Ginseng Yangrong Pills when their properties change.

8. Children must use it under adult supervision.

9. Please keep Ginseng Yangrong Pills out of reach of children.

10. If you are using other drugs, please consult your physician or pharmacist before using Ginseng Yangrong Pills. 7.9 Drug interactions

Drug interactions may occur if used together with other drugs. Please consult your physician or pharmacist for details.

7.10 Remarks