Professor, Head of Department of Medicinal Chemistry, School of Medicine, Xi Jiaotong University, Doctor of Science, Senior Member of Chinese Pharmaceutical Society, Member of chinese chemical society, Member of American Chemical Society. In recent three years, he has undertaken undergraduate professional teaching and experimental courses such as pharmaceutical chemistry, pharmaceutical technology curriculum design, chemical pharmaceutical technology and new drug design; At the same time, in the past three years, lectures have been held to help undertake postgraduate courses such as contemporary organic drug synthesis, introduction to new drug research, and quantitative pharmacology. He won the third prize of bilingual teaching of Xi Jiaotong University twice, presided over the postgraduate education reform project of Xi Jiaotong University, and studied 1 contemporary organic drug synthesis teaching materials.
Chinese name: Meng Ge
Nationality: China.
Ethnic group: Han nationality
Place of birth: Kaifeng, Henan
Date of birth: 1968.03
Occupation: Professor
Graduate institutions: Shandong University and Fudan University.
Masterpiece: Translation of Guide to Organic Synthesis
Basic situation
Editor of international professional academic journals "Molbank" and "International Journal Alofhiv/Aidsand Research" (IHR), and reviewer of international professional journal "Bioorg". Medical chemistry and biomedical chemistry letters
Business experience
2011.07-20112, University of Vienna, Austria, doing research work in the Department of Medicine and Natural Products Synthesis.
From March 2008 to March 2009, I visited Michigan Institute of Technology as a postdoctoral fellow to study the synthesis of near infrared fluorescent molecular probes.
From June 2004 to July 2006, he conducted postdoctoral research in Tsinghua University, mainly engaged in the synthesis of heterocyclic drug intermediates;
1992.07-1999.05438+0, engaged in teaching and scientific research in the Department of Pharmacy, Medical College of Henan University, as a teaching assistant and lecturer;
learn from others'experience
1985.09- 1989.07, majoring in chemistry, Department of Chemistry, Henan University, bachelor of science degree;
1989.09- 1992.07, majoring in medicinal chemistry, Department of Pharmacy, Shandong Medical University, Master of Science;
1999.09-2003 5438+0, majoring in organic drug synthesis, Fudan University, with a doctor of science degree;
Teaching and scientific research
Published 42 academic papers in professional journals at home and abroad, of which 16 were included in SCI or EI. Participate in domestic and international 14 professional academic exchange conferences, and receive papers, wall newspaper exhibitions or oral reports respectively. He presided over 3 basic research projects, international horizontal cooperation projects 1, applied basic research projects 1 and horizontal technology development projects 1. He won the 1 international paper award, national paper award, provincial scientific research achievement award and bureau-level paper award respectively, and won two teaching competition awards. * * * Editor-in-chief of 2 textbooks, co-editor of 2 textbooks, and independent translation of monographs 1 department.
research project
The research fields and topics mainly include the following two aspects:
1) Study on the synthetic route and process improvement of contemporary new drugs.
Some new drugs listed in recent years are selected as the research objects of synthesis process, and new methods and reagents of contemporary organic synthesis are adopted to optimize their processes and study environmental protection. In recent years, the drugs concerned are: non-steroidal anti-inflammatory drug loxoprofen sodium; Multi-target tyrosine kinase inhibitors, such as sunitinib, sorafenib, repafen, verofinib, dasatinib, etc. Anti-Alzheimer's drugs, such as memantine hydrochloride, oxiracetam and edaravone. New hypoglycemic drugs, such as rosiglitazone, pioglitazone, and cycloglitazone. Anti-anxiety drugs, such as olanzapine and escitalopram. And ibandronic acid as an adjuvant therapy for tumor.
2) Design, synthesis and structure-activity relationship of selective enzyme inhibitors.
Taking the enzymes related to major diseases as the drug design goal, based on the basic nucleus and other active structural fragments of natural active nitrogen-containing alkaloids, with the help of computer-aided drug design (CADD), small molecular inhibitors with nitrogen-containing or sulfur-containing heterocyclic structures were designed and optimized, and the biological activity data obtained from related enzyme activity inhibition screening experiments were used to further study their structure-activity relationship (SAR). Quantitative structure-activity relationship (QSAR, such as CoMFA, CoMSIA, HQSAR, etc. ) and pharmacophore model (GASP, DISCO, etc.) were studied. ) is summarized. In recent years, the targets of attention are: HIV- 1 reverse transcriptase, protein tyrosine phosphatase (PTP 1B), Raf kinase, etc.
project
Published papers
Papers published in recent three years
Winning record
Won the second prize of Shaanxi University Science and Technology Award.