Treatise on febrile diseases is a landmark work with epoch-making significance in the history of the development of febrile diseases in traditional Chinese medicine, and it is a prominent embodiment of the original thinking of traditional Chinese medicine theory and new methods of clinical verification. Wu Youke in Ming Dynasty is divided into two volumes, which was written in the fifteenth year of Chongzhen in Renwu (1642). Wu Youke created the theory of "sudden anger" in Treatise on Epidemic Febrile Diseases, emphasizing that epidemic febrile diseases are completely different from typhoid fever, and clearly pointing out that "epidemic febrile diseases are diseases, not wind, cold, summer heat and dampness, but different gas senses between heaven and earth". The thinking mode of exterior-interior syndrome differentiation treatment was established, and effective prescriptions for treating febrile diseases such as Dayuanyin were created. It has had a far-reaching impact on the formation and development of epidemic febrile diseases in later generations.
According to the Records of Wujiang County, at the time of writing Treatise on Epidemic Febrile Diseases, there were epidemics in Wuxian county for years, with more than 100 households in one lane, and none of them were spared. There are dozens of mouths in a door, and none of them survive. Wu Youke said in the original preface of Treatise on Epidemic Febrile Diseases that "Chongzhen is new, epidemic gas is prevalent, and there are many people who feel it. May and June are very beneficial, or contagious. At the time of its origin, every time I saw it, the teacher mistakenly treated the rule of law with positive typhoid fever. No one is in danger ... the doctor is at a loss and the patient's life is dying. The more urgent the illness, the more chaotic the medical care. Don't die of illness, but die of medicine; I didn't die from medicine, but from the forgetting of ancient books. " Under such circumstances, he deeply felt the shortage of medicine at that time, and lamented that "keeping the ancient law is not suitable for today's disease, giving up today's disease without searching for ancient books, and medication is ineffective ... For thousands of years, his misfortune in Sheng Min has been like this". Therefore, clinically, he "meditated without observing his feelings, entered his door, reached his place, and changed with his husband" and wrote Epidemic Fever.