The collation and publication of ancient books is a major event that concerns future generations, and it should not only serve the present, but also serve future generations. To sort out ancient books, we must first preserve their original appearance as much as possible and improve the sorting level; Secondly, further innovate collating forms and methods, strengthen quality management, and comprehensively improve the overall level of collating and publishing ancient medical books. The arrangement and publication of ancient medical books is different from the publication of general books, and its quality involves copying, photocopying, collating, punctuation, annotation, indexing and other factors. However, in recent years, with the rise of "TCM fever" at home and abroad, traditional ancient medical books have been favored, and some non-professional publishing houses are also eager to publish books. The phenomenon of disorderly labeling, annotation and translation of ancient medical books is serious, the collation style is inconsistent, and the editing style is neither fish nor fowl. A large number of classic medical books are repeatedly published at a low level, which affects the overall quality level of the collation and publication of ancient medical books. In view of the above situation, the author makes the following discussion on the related issues affecting the quality of the collation and publication of ancient Chinese medicine books, so as to sum up the experience and lessons and improve the level of the collation and publication of ancient Chinese medicine books.