2 English reference Ive Nuangong Pill [2 1 Century Bilingual Dictionary of Science and Technology]
Aifu Nuangong Pill [Chinese Medicine Terminology Committee]. Terminology of Traditional Chinese Medicine (2004)]
Chinese medicine terminology committee. Terminology of Traditional Chinese Medicine (2004)]
3. National essential drugs and information on retail guidance prices of national essential drugs related to Aifu Nuangong Pills.
Essential drug serial number
DirectoryNo. Drug name, dosage form and specification Retail unit refers to
Remarks on price category 977 84 Aifu Nuangong Pill 9g pill 0.8 Chinese patent medicine part * 978 84 Aifu Nuangong Pill 54g bottle 4.2 Chinese patent medicine part 979 84 Aifu Nuangong Pill 6g bag 0.96 Chinese patent medicine part 980 84 Aifu Nuangong Pill 45g bottle 7.2 Chinese patent medicine part 98 1 84 Aifu Nuangong Pill 54g bottle 8.6 Chinese patent medicine part 982 84 Aifu Nuangong Pill 6000.
1. The dosage form specifications marked with "*" in the remarks column in the table are representative products.
2. Specifications of dosage forms with "△" in the remarks column in the table, and other specifications of the same dosage form are tentative prices.
3. The dosage form specifications are indicated in the remarks column. The prices of other specifications in this dosage form are based on the same usage and dosage, and are calculated according to the drug price comparison rules.
4. The "honey pills" marked in the column of dosage form in the form include small honey pills and big honey pills.
4 Overview Aifu Nuangong Pill is the prescription name, and there are about five kinds of prescriptions with the same name.
The main components of Aifu Nuangong Pill are Folium Artemisiae Argyi (charcoal), Rhizoma Cyperi (fried with vinegar), Fructus Evodiae (processed), Cortex Cinnamomi, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Alba (fried with wine), Radix Rehmanniae, Radix Astragali (fried with honey) and Radix Dipsaci [1]. Has the effects of regulating qi and nourishing blood, warming uterus and regulating menstruation. It can be used for treating menoxenia and dysmenorrhea caused by deficiency of blood and qi stagnation and deficiency of cold in lower energizer, with symptoms such as menoxenia, scanty menstruation, blood clot, abdominal pain, abdominal pain during menstruation, abdominal pain, waist and knee pain, etc.
People's Republic of China (PRC) Pharmacopoeia (20 10 edition) records the pharmacopoeia standard of this Chinese patent medicine.
5 Renzhai Zhi Zhi Fang Lun Volume 26 Aifu Nuangong Pill 5. 1 Consists of Rhizoma Cyperi (vinegar) 62, Folium Artemisiae Argyi, Radix Angelicae Sinensis (washed with wine) 32, Radix Astragali, Fructus Evodiae, Rhizoma Chuanxiong, Radix Paeoniae Alba (fried with wine) 22, Radix Rehmanniae (steamed with wine) 12, laurel 52, and Radix Dipsaci one and a half []
5.2 The preparation method is that the medicine is powder, the vinegar paste is pill, and the plane tree is big [2].
5.3 Usage and dosage of Aifu Warm Palace Pills: 50 ~ 70 pills each time, and vinegar soup is far away [2].
5.4 Function Indications: Aifu Nuangong Pill in the 26th prescription of Renzhai Zhi Zhi Prescription has the functions of warming uterus, regulating menstruation and relieving pain [2]. Indications: cold in the uterus, leukorrhagia, sallow complexion, aching limbs, listlessness, anorexia, irregular meridians, dull complexion, abdominal pain, infertility due to long marriage [2].
6. Prescription of Aifu Nuangong Pill (26 prescriptions) in Appendix to Renzhai Zhi 6. 1: 90g of Folium Artemisiae Argyi (with leaves removed, branches removed and stems removed), and 80g of Rhizoma Cyperi1(timely harvested, boiled in vinegar 1l in a stone jar for one day and night, mashed into cakes, and.
3 taels of Folium Artemisiae Argyi (defoliation and stem removal), 6 taels of Rhizoma Cyperi (adding 5 liters of vinegar, boiling in a crock for 65,438+0 days and nights, mashing into cakes and baking with slow fire), 2 taels of Evodia rutaecarpa (stem removal), 2 taels of Rhizoma Chuanxiong (with birds) and 2 taels of Radix Paeoniae Alba (fried with wine).
6.2 Preparation method * * * is fine powder, and rice vinegar is pasted into pills, which are as big as buttonwood.
6.3 The main function is Aifu Nuangong Pill, the 26th prescription of Renzhai Zhixue Attached, which has the effects of warming meridians and officials, nourishing blood and preventing miscarriage. Indications: cold uterus, leucorrhea, sallow complexion, limb pain, fatigue, anorexia, irregular menstruation, colorless blood, abdominal pain, and long-term infertility. (infertility)
6.4 Usage and dosage of Aifu Nuangong Pills: Take 50 ~ 70 pills each time, and take them with light vinegar soup on an empty stomach.
Take 5070 capsules each time, and send light vinegar soup before eating.
6.5 Pay attention to avoid irritation and cold during medication.
Avoid anger and indifference.
6.6 Source "Ren Zhai Zhi Attached Legacy" Volume 26
7 "Rejuvenation of All Diseases" Volume 7. 1 Liumian Aifu Warm Palace Pill Prescription: South Cyperus rice 1 kg (4 in vinegar, 4 in soup, 4 in toilet, 4 in wine, each in kloc-0/night, baked), and North Artemisia argyi leaves (baked and mashed).
7.2 The preparation method is fine powder and vinegar paste is pill, such as buttonwood.
7.3 Function Indications: Six-party Aifu Nuangong Pill is used to indicate women's uterine deficiency, irregular menstruation, abdominal pain and leucorrhea with red and white discharge.
7.4 Usage and dosage of Aifu Nuangong Pills: 7080 capsules each time, with hollow rice soup; The wine is very good.
7.5 Source "Rejuvenation of All Diseases" Volume 6
8 "Gynecology Essentials" Volume II Aifu Warm Palace Pill 8. 1 Prescription: Folium Artemisiae Argyi, Rhizoma Cyperi (four series), Rhizoma Corydalis, Radix Rehmanniae Preparata and Radix Glycyrrhizae.
8.2 The preparation method is the end, and the vinegar paste is a pill, which is as big as a buttonwood.
8.3 Functional indications: Volume II of Gynecology Essentials "Aifu Nuangong Pill" is the indication for blood addiction; Deficiency cold of uterus, irregular menstruation, abdominal pain, leucorrhea with red and white discharge.
8.4 Aifu Nuangong Pills Usage and Dosage: 80 capsules each time, and rice soup is taken.
8.5 Source "Gynecology Essentials" Volume II
9 "Guide to Ancient and Modern Medication" Volume 1 1 Aifu Nuangong Pill 9. 1 prescription Nanxiangfu (hair removal net) 1 kg (divided into four systems: soaked in wine for 4 liang, soaked in vinegar for 4 liang, soaked in salt soup for 4 liang, and soaked in children's excrement for 4 or 3 days, which is fine powder).
9.2 The preparation method is the end, and the vinegar paste is a pill, which is as big as a buttonwood.
9.3 The main function is Aifu Nuangong Pill, which has eleven prescriptions in ancient and modern medical records, and has the effects of regulating qi, enriching blood, regulating menstruation and regulating seeds. Treating all diseases of women; The woman's menstruation is irregular, and she has pain before leaving. Her uterus is cold and she can't get pregnant.
9.4 Usage and dosage of Aifu Nuangong Pills: 80 capsules each time, with light vinegar soup.
9.5 Schools discuss 1. "Medical Forest Compilation": Four things are proud of liver and blood, love and warm palace, and they are collected with vinegar to avoid mistakes. Nourishing beads with warmth is the foundation of living things.
2. "Easy to read": Where women regulate menstruation, they must first adjust their qi, and the qi will be smooth, and the blood will be smooth. Husband and blood, like warmth and hate cold, cold is dystocia, and warmth is easy to get pregnant. Therefore, it is suitable to treat the above syndromes by regulating qi with Rhizoma Cyperi and warming uterus with Folium Artemisiae Argyi.
9.6 Source: Ancient and Modern Medical Records 1 1
10 Pharmacopoeia Standard of Aifu Warm Palace Pills 10. 1 is called Aifu Warm Palace Pills.
Aifu Nuangong Pill
10.2 Prescription: Folium Artemisiae Argyi (charcoal)120g, Rhizoma Cyperi vinegar 240g, Evodia rutaecarpa preparata 80g, Cortex Cinnamomi 20g, Radix Angelicae Sinensis120g, Rhizoma Chuanxiong 80g, Radix Paeoniae Alba (stir-fried with wine) 80g, Radix Rehmanniae 40g, Radix Astragali preparata 80g, Radix Astragali preparata 80g.
10.3 Prepare the above ten medicinal materials, pulverize them into fine powder, sieve them and mix them evenly. Every 100g powder is added with refined honey 1 10 ~ 130 g to make small honey pills or large honey pills.
10.4 characteristics this product is a small honey pill or a big honey pill, with a dark brown to black color; Slight gas, sweet and bitter taste, spicy.
10.5 Identification (1) Take this product and observe it under the microscope: T-shaped hair is brown or dark brown, curved and has 2-4 cells (mugwort leaves). Non-glandular hair 2 ~ 6 cells, some of which are filled with reddish-brown substances; The head of glandular hair is multicellular, oval, containing brownish yellow to brownish red, and the stalk is 2 ~ 5 cells (Evodia rutaecarpa). The secretory cells are round and contain yellowish brown to reddish brown secretions, and the surrounding cells are radially arranged (vinegar Cyperus rotundus). Thin-walled cells are spindle-shaped, with slightly thicker walls and extremely fine oblique staggered textures (Angelica sinensis). Calcium oxalate cluster crystals are about 45μm in diameter and exist in pale brown shriveled parenchyma cells, with a constant number and arranged in rows (dipsacus asperata). The fiber diameter is 1.5 ~ 35 microns, the wall thickness is slightly lignified, and there are large round holes (peony). Fibers are bundled or scattered, with thick walls and longitudinal cracks on the surface, and both ends are broken into broom-like or relatively flat segments (roasted astragalus). Stone cells are square or round with thin walls (cinnamon).
(2) Take 9g of this product, chop it up, add 20ml of ether, perform ultrasonic treatment for 20min, filter, evaporate the filtrate, and add 0.5ml of n-hexane to the residue to make it dissolve, so as to serve as the test solution. In addition, α-cyperone was taken as reference substance, and n-hexane was added to make a solution containing 2μl per kloc-0/ml as reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia I, 20 10), 20μl of the test solution and 10μl of the reference solution were respectively absorbed on the same silica gel GF254nm thin-layer plate, and ethyl benzene acetate (19: 1) was used as the developing agent, and then unfolded and taken out. In the chromatogram of the test sample, spots with the same color appear in the position corresponding to the chromatogram of the reference sample; Spray dinitrophenylhydrazine ethanol test solution and let it stand for a while, and the spots gradually turn orange-red.
(3) Take 4.5g of this product, chop it up, add 65438±00ml of ethanol, heat and reflux it for 65438 0 hours, let it cool, filter it, and take the filtrate as the test solution. In addition, 0.2g of Evodia rutaecarpa was taken as the control medicinal material, and the control medicinal material solution was prepared by the same method. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia I, 20 10), absorb the above two solutions 10μl, spot them on the same silica gel G thin-layer plate respectively, and use the upper solution of n-butanol-acetic acid-water (2: 1: 1) as the developing agent, unfold and take them out. In the chromatogram of the test sample, fluorescent spots with the same color appear at the positions corresponding to the chromatogram of the control medicinal materials.
(4) Take 9g of this product, cut it into pieces, soak it in 5ml of water, add 30ml of water-saturated n-butanol, shake it evenly, perform ultrasonic treatment for 65438 00 minutes, filter it, evaporate the filtrate, and dissolve the residue in 2ml of ethanol as the test solution. In addition, paeoniflorin reference substance was added with ethanol to prepare a solution containing 2mg per 1ml as reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia I, 20 10), absorb 5 ~ 10μ l of the above two solutions, spot them on the same silica gel G thin-layer plate, and use chloroform-ethyl acetate-methanol-formic acid (40: 5: 10: 0.2) as the developing agent. In the chromatogram of the test sample, spots with the same color appear in the position corresponding to the chromatogram of the control sample.
(5) Take 9g of this product, cut it into pieces, soak it in 5ml of water, add 30ml of water-saturated n-butanol, shake it evenly, perform ultrasonic treatment for 65438 00 minutes, filter it, wash the filtrate with ammonia solution twice, 30ml each time, discard the ammonia solution, evaporate the n-butanol solution, and add 65438±0ml of methanol to dissolve the residue as the test solution. Another astragaloside IV reference substance was added with methanol to prepare a solution containing 0.5mg per kloc-0/ml as the reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia I, 20 10), respectively absorb 10μl test solution and 5μl reference solution on the same silica gel G thin-layer plate, and use chloroform-methanol-water (13: 7: 2) lower solution as developing agent, unfold, take out and dry. In the chromatogram of the test sample, fluorescent spots with the same color appear in the position corresponding to the chromatogram of the control sample.
10.6 the inspection shall comply with the relevant provisions under pills (appendix 1A of China Pharmacopoeia I, 20 10).
The content of 10.7 was determined by high performance liquid chromatography (appendix ⅵ D of Pharmacopoeia I, 20 10 edition).
10.7. 1 chromatographic conditions and system applicability test: octadecylsilane bonded silica gel is used as filler; Acetonitrile -0. 1% phosphoric acid solution (12: 88) was used as the mobile phase; The detection wavelength is 230 nm. The theoretical plate number should be not less than 3000 calculated by paeoniflorin peak.
10.7.2 preparation of reference substance solution take a proper amount of paeoniflorin reference substance, weigh it accurately, and add 50% methanol to make a solution containing 50μg per 1ml.
10.7.3 preparation of test solution take this product as honey pill, chop it up, take 2g, and weigh it accurately; Or take honey pills with different weight, cut into pieces, take 2g, accurately weigh them, put them in a conical bottle with a stopper, accurately add 25ml of 50% methanol, plug them, weigh them, perform ultrasonic treatment (power 300W, frequency 50kHz) for 40min, let them cool, weigh them again, make up the lost weight with 50% methanol, shake them evenly, and filter them.
10.7.4 determination method Accurately suck the control solution and the test solution 10μl respectively, inject them into the liquid chromatograph, and determine to obtain the product.
This product contains paeoniflorin (C23H28O 1 1), and Xiaomi pill shall not be less than 0.45 mg per1g; Damivan should not be less than 4.0 mg per pill.
10.8 function and main governing qi and nourishing blood, warming uterus and regulating menstruation. It can be used for treating menoxenia and dysmenorrhea caused by deficiency of blood and qi stagnation and deficiency of cold in lower energizer, with symptoms such as menoxenia, scanty menstruation, blood clot, abdominal pain, abdominal pain during menstruation, abdominal pain, waist and knee pain, etc.
10.9 Administration and dosage taken orally. 9g of small honey pills once, 9 g of big honey pills once 1 capsule, 2 ~ 3 times a day.
10. 10 honey pills each weigh 9g.
10. 1 1 storage seal.
10. 12 Edition People's Republic of China (PRC) Pharmacopoeia 20 10 Edition
1 1 drug description of Aifu Nuangong Pill 1 1. 1 drug type Chinese medicine
1 1.2 Drug name: Aifu Nuangong Pill
1 1.3 Chinese phonetic alphabet of drugs 1 1.4 English name of drugs 1 1.5 components 1 1.6 characters1/kloc. It can be used for treating menoxenia and dysmenorrhea caused by blood deficiency and qi stagnation, and deficiency and cold of lower energizer, with symptoms such as menoxenia, scanty menstruation, blood clot, abdominal pain, abdominal pain during menstruation, abdominal pain, waist and knee pain, etc.
Usage and dosage 1 1.9 specification 1 1. 10 Iv Nuangong Pills for oral administration. 9 grams of honey pills each time, 2 ~ 3 times a day.
11.11contraindications1.12 Adverse reactions1.13 Precautions. Avoid cold food and take a cold bath.
2. Patients with cold and fever should not take it.
3. People suffering from serious chronic diseases such as hypertension, heart disease, liver disease, diabetes and kidney disease should take it under the guidance of a doctor.
Adolescent girls and menopausal women should take it under the guidance of a doctor.
People with normal menstruation, sudden hypomenorrhea, menstrual disorder or irregular bleeding should go to the hospital.
6. To treat dysmenorrhea, it is advisable to start taking medicine 3 ~ 5 days before menstruation, taking 1 week. If you have fertility requirements, you should take it under the guidance of a doctor.
7. If the dysmenorrhea is not relieved after taking the medicine, or it is very serious, you should go to the hospital for treatment.
8. Treatment of irregular menstruation. After taking the medicine 1 month, the symptoms have not been relieved, so you should go to the hospital.
9. It is forbidden for those who are allergic to this product, and should be used with caution for those who are allergic.
10. It is forbidden to use this product when its properties change.
1 1. Please keep this product out of the reach of children.
12. If you are using other drugs, please consult a doctor or pharmacist before using this product.
1 1. 14 If used with other drugs, drug interactions may occur. Please consult a doctor or pharmacist for details.
1 1. 15 Pharmacological effects of Aifu Nuangong Pills 1 1. 16 Remarks