2 English reference Biyan tablets [Committee of Traditional Chinese Medicine Terminology. Terminology of Traditional Chinese Medicine (2004)]
Biyan Tablet [Committee of Terminology of Traditional Chinese Medicine]. Terminology of Traditional Chinese Medicine (2004)]
Overview Biyan Tablet is a Chinese patent medicine, and its main components are Xanthium sibiricum, Flos Magnoliae, Radix Saposhnikoviae, Fructus Forsythiae, Flos Chrysanthemi Indici, Fructus Schisandrae Chinensis, Radix Platycodi, Radix Angelicae Dahuricae, Rhizoma Anemarrhenae, Herba Schizonepetae, Radix Glycyrrhizae, Cortex Phellodendri, Herba Ephedrae and Asari [1]. Has the effects of expelling pathogenic wind, dispersing lung qi, and clearing away heat and toxic materials. It is used for acute and chronic rhinitis with wind-heat accumulating in lung, with symptoms of nasal congestion, runny nose, fever and headache.
Some pharmacopoeia standards are recorded in People's Republic of China (PRC) Pharmacopoeia (20 10 edition).
4 efficacy and indications Biyan tablets have the effects of expelling wind and dispersing lung, clearing away heat and detoxifying. It is used for acute and chronic rhinitis with wind-heat accumulating in lung, with symptoms of nasal congestion, runny nose, fever and headache. (People's Republic of China (PRC) Pharmacopoeia (20 10 Edition))
Biyan tablets have the effects of expelling wind and clearing heat, dispersing lung qi and inducing resuscitation, and are mainly used to treat rhinitis [2].
The pharmacopoeia standard of Biyan tablets is 5. 1.
Biyan tablets
5.2 Prescription Xanthium sibiricum, Flos Magnoliae, Radix Saposhnikoviae, Fructus Forsythiae, Flos Chrysanthemi Indici, Fructus Schisandrae Chinensis, Radix Platycodi, Radix Angelicae Dahuricae, Rhizoma Anemarrhenae, Herba Schizonepetae, Radix Glycyrrhizae, Cortex Phellodendri, Herba Ephedrae and Asari.
5.3 Prepare the above fourteen medicines, and pulverize Radix Angelicae Dahuricae, Radix Platycodi and part of Cortex Phellodendri into fine powder; Distilling Flos Magnoliae, Flos Chrysanthemi Indici, Asari and Herba Schizonepetae to extract volatile oil, and collecting the distilled aqueous solution in another container; Pulverizing Herba Ephedrae, Rhizoma Anemarrhenae and Fructus Schisandrae into coarse powder, percolating with 60% ethanol as solvent, collecting percolate, and recovering ethanol; Decocting the other four herbs, such as Cortex Phellodendri and Fructus Xanthii, in water for 2 hours each time, mixing decoctions, adding distilled aqueous solution and percolate, concentrating to a relative density of about 65,438+/-0.25, spray drying into fine powder, adding the above fine powder, mixing, granulating, drying, spraying the above volatile oil, pressing into tablets, and sugar coating small tablets; You can get a large piece of film-covered clothes.
5.4 Characteristics This product is a sugar-coated tablet or a film-coated tablet, which is brown after the coating is removed; The smell is sweet and the taste is bitter.
5.5 Identification (1) Take this product and observe it under the microscope: the starch granules are composed of 8 ~ 12 fractions (angelica dahurica). The diameter of the milk-separating tube is 65438 0.4 ~ 25 microns, and it contains pale yellow granules (Platycodon grandiflorum).
(2) Take 20 sugar-coated tablets or 12 film-coated tablets of this product, remove the coating, grind, add 60ml of diethyl ether, perform ultrasonic treatment for 20 minutes, filter, volatilize diethyl ether from the filtrate, and add ethyl acetate 1ml to the residue to make it dissolve, so as to serve as the test solution. In addition, 0.5g of Radix Angelicae Dahuricae was taken as the control medicinal material, and 20ml of ether was added to prepare the control medicinal material solution in the same way. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia Part I, 20 10), respectively absorb 5μl of the above two solutions on the same silica gel G thin-layer plate, use petroleum ether (60 ~ 90℃)- diethyl ether (3: 2) as developing agent, unfold, take out, dry and check under ultraviolet lamp (365nm). In the chromatogram of the test sample, the fluorescent main spots with the same color are displayed at the positions corresponding to the chromatogram of the control medicinal materials.
(3) Take 20 sugar-coated tablets or 12 film-coated tablets of this product, remove the coating, grind, add 60ml of ether, reflux extract 1 hour, filter, take the filtrate, wash it with 5% sodium carbonate solution for three times, use 15ml each time, discard the sodium carbonate solution, and use/kloc-0 again. In addition, 65438 0 g of Fructus Forsythiae was taken as the control medicinal material, and the control medicinal material solution was prepared by the same method. According to the test of thin-layer chromatography (appendix ⅵ b of China Pharmacopoeia, Part I, 20 10), the test solution 10μl and the control medicinal solution 2μl were absorbed respectively, and the samples were mixed in the same silica gel G prepared with 2% sodium hydroxide solution and chloroform-ethyl acetate-methanol (10: 5: 1).
(4) Take 0/0 sugar-coated tablets or 6 film-coated tablets of this product, remove the coating, grind, add 30ml of ethyl acetate, perform ultrasonic treatment for 30 minutes, filter, evaporate the filtrate, add a proper amount of methanol to dissolve the residue, and add it to a neutral alumina column (100 ~ 200 mesh, 3g, inner diameter/kloc-0. In addition, the magnolin reference substance was added with methanol to prepare a solution containing 1μl as the reference substance solution. According to the thin-layer chromatography test (Appendix ⅵ b of Pharmacopoeia I, 20 10), respectively absorb 5μl of test solution10 and reference solution on the same silica gel H thin-layer plate, and use chloroform-ether (5: 1) as the developing agent, unfold, take out, dry and spray 65438+. In the chromatogram of the test sample, the same purple-red spots appear in the position corresponding to the chromatogram of the control sample.
5.6 The content was determined by high performance liquid chromatography (Appendix ⅵ D of China Pharmacopoeia I, 20 10).
5.6. 1 chromatographic conditions and system applicability test: octadecylsilane bonded silica gel is used as filler; Acetonitrile water (38: 62) was used as the mobile phase; The detection wavelength is 278 nm. According to the peak of magnolin, the theoretical plate number should not be less than 7000.
5.6.2 Preparation of reference solution Take an appropriate amount of magnolin reference substance, weigh it accurately, and add methanol to make a solution containing 6μg per kloc-0/ml.
5.6.3 Preparation of test solution Take this product 10 tablet, remove the coating, weigh it accurately, grind it, take about 1g, weigh it accurately, put it in a conical flask with a stopper, add 25ml of methanol accurately, plug it, weigh it, and perform ultrasonic treatment (power 150W, frequency 20W). Accurately measure 5ml of continuous filtrate, put it on neutral alumina column (2g, inner diameter 100 ~ 200 mesh, packed in column by wet method, pre-washed with methanol), elute with appropriate amount of methanol, collect the eluate in a 10ml volumetric flask, collect it until it is close to 10ml, and add methanol to the scale.
5.6.4 Determination method: Accurately absorb 20μ l of control solution and 20μ l of test solution respectively, inject them into liquid chromatograph, and determine to obtain the product.
Each tablet of this product contains Magnoliaceae (C23H28O7), and the sugar-coated tablet shall not be less than 60μ g; Film-coated tablets shall not be less than 0. 10mg.
5.7 Function indications: expelling wind and dispersing lung, clearing away heat and toxic materials. It is used for acute and chronic rhinitis with wind-heat accumulating in lung, with symptoms of nasal congestion, runny nose, fever and headache.
5.8 Oral administration and dosage. 3 ~ 4 tablets (sugar-coated tablets) or 2 tablets (film-coated tablets) at a time, 3 times a day.
5.9 specification diaphragm? Each tablet weighs 0.5g.
5. 10 storage seal.
5. 1 1 Edition People's Republic of China (PRC) Pharmacopoeia 20 10/Edition.
6 Biyan Tablet Drug Instructions 6. 1 Drug Name Biyan Tablet
6.2 Chinese Pinyin of Biyan Tablets
6.3 dosage form film-coated tablets: each tablet weighs 0.5g
6.4 Biyan tablets are sugar-coated tablets or film-coated tablets, which turn brown after removing the coating; The smell is sweet and the taste is bitter.
6.5 Biyan Tablet is mainly composed of Xanthium sibiricum, Flos Magnoliae, Radix Saposhnikoviae, Fructus Forsythiae, Flos Chrysanthemi Indici, Fructus Schisandrae, Radix Platycodi, Radix Angelicae Dahuricae, Rhizoma Anemarrhenae, Herba Schizonepetae, Radix Glycyrrhizae, Herba Ephedrae, Asari and Cortex Phellodendri.
6.6 Biyan Tablet is mainly used for expelling wind and dispersing lung, clearing away heat and toxic materials. It is used for acute and chronic rhinitis with wind-heat accumulating in lung, with symptoms of nasal congestion, runny nose, fever and headache.
6.7 Usage and dosage of Biyan tablets are taken orally. 3 ~ 4 tablets (sugar-coated tablets) or 2 tablets (film-coated tablets) at a time, 3 times a day.
6.8 Precautions 1. Avoid alcohol, tobacco, spicy and fishy food.
2. It is not advisable to take nourishing Chinese medicine at the same time during medication.
3. Patients with hypertension and heart disease should use it with caution. Patients with serious chronic diseases such as liver disease, diabetes and kidney disease should take it under the guidance of a doctor.
4. Children, pregnant women, lactating women, the elderly and the infirm, and loose stool with spleen deficiency should be taken under the guidance of a doctor.
5. Take it in strict accordance with the usage and dosage. This product is not suitable for long-term use.
6. If the symptoms are not relieved after taking the medicine for 3 days, you should go to the hospital.
7. It is forbidden for those who are allergic to Biyan tablets, and should be used with caution for those who are allergic.
8. When the nature of Biyan tablets changes, it is forbidden to use them.
9. Children must use it under the supervision of adults.
10. Please keep this product out of the reach of children.
1 1. If you are using other drugs, please consult a doctor or pharmacist before using this product.
6.9 Drug Interaction If used together with other drugs, drug interaction may occur. Please consult a doctor or pharmacist for details.
6. 10 Remarks