Contents 1 Pinyin 2 English reference 3 Overview 4 Latin name 5 English name 6 Alias ??of Phellodendron 7 Origin 8 Original plant form 9 Origin 10 Harvesting and initial processing 11 Crude drug properties 12 Meridian tropism of nature and flavor 13 Phellodendron’s Efficacy and Indications 14 Chemical composition of Cortex Phellodendron 15 Pharmacopoeia standard of Cortex Phellodendri 15.1 Product name 15.2 Source 15.3 Characteristics 15.4 Identification 15.5 Inspection 15.5.1 Moisture content 15.5.2 Total ash 15.6 Extract 15.7 Content determination 15.7.1 Berberis chinensis 15.7.2 Phellodendron cypress 15.8 Cortex Phellodendron decoction pieces 15.8.1 Preparation 15.8.1.1 Phellodendron Cortex 15.8.1.1.1 Identification, inspection, and content determination 15.8.1.2 Salted Phellodendron Cortex 15.8.1.2.1 Identification, inspection, and content determination 15.8.1.3 Phellodendron Cortex charcoal 15.8.2 Nature, flavor, and meridians 15.8.3 Functions and indications 15.8.4 Usage and dosage 15.8.5 Storage 15.9 Source 16 Attached reference materials: 1 Prescriptions using the Chinese medicine Cortex Phellodendron 2 Chinese patent medicines using the Chinese medicine Cortex Phellodendron 3 Cortex Phellodendri in ancient books* Cortex Phellodendri drug instructions 1 Pinyin < /p>
huáng bǎi 2 English reference
amoorcorn tree bark [Xiangya Medical Professional Dictionary]
cortex phellodendri [Xiangya Medical Professional Dictionary]
phellodendri cortex [Xiangya Medical Professional Dictionary]
Phellodendron amurense [Xiangya Medical Professional Dictionary]
corktree bark [Xiangya Medical Professional Dictionary] < /p>
Cortex Phellodendri (LA) [Traditional Chinese Medicine Terminology Approval Committee. Traditional Chinese Medicine Terminology (2004)]
amur corktree [Traditional Chinese Medicine Terminology Approval Committee. Traditional Chinese Medicine Terminology (2004)] 3 Overview
Phellodendron
Cortex Phellodendri is the name of a traditional Chinese medicine, published in "Compendium of Materia Medica". It is the dried bark of Phellodendron chinense Schneid. or Phellodendron amurense Rupr. of the Rutaceae plant [1].
"The Pharmacopoeia of the People's Republic of China" (2010 edition) records the pharmacopoeia standards of this traditional Chinese medicine. 4 Latin name
Cortex Phellodendri (La) ("Terms of Traditional Chinese Medicine (2004)") 5 English name
amur corktree ("Terms of Traditional Chinese Medicine (2004)") 6. Alias
Guan Huangbai.
Barberry, Barberry bark, Barberry wood[2]. 7 Sources
Phellodendron is the dried bark of Phellodendron chinense Schneid. or Phellodendron amurense Rupr. [1] of the Rutaceae plant.
Phellodendron chinense Schneid. Phellodendron chinense Schneid. or Phellodendron P. amurense Rupr. bark[2].
Phellodendron is the bark of the Rutaceae plant Phellodendron amurense Rupr. The bark of the same plant, P. chinense Schneid. (commonly known as "Sichuan Phellodendron") has the same effect as Cortex Phellodendron. 8 Original plant form
Tree, 10~25m high. The bark is light yellowish brown or light gray, the cork layer is thick and soft, and there are regular deep longitudinal fissures. The leaves are opposite, pinnately compound, with 5 to 13 leaflets, ovate or ovate-lanceolate, 5 to 12cm long, 3 to 4.5cm wide, with finely serrated or wavy edges, dark green above and pale below. color. The panicle is terminal, dioecious, with small and numerous flowers, yellow-green. The berry-like drupe is spherical, purple-black, and fragrant. The flowering period is from May to June, and the fruiting period is from September to October.
Born in deep mountains, riversides, and forests beside streams.
9 Origin
Cortex cypress is mainly produced in Liaoning, Jilin, and Hebei.
The species derived from Huangbark tree is commonly called Sichuan Phellodendron and is mainly produced in Sichuan [2];
The species derived from Cork Barberry is commonly called Guan Phellodendron and is mainly produced in Northeast China [2]. 10 Harvesting and initial processing
Peel off the bark from March to June, scrape off the rough bark while it is fresh, and dry it in the sun, which is called "Guan Huangbai". 11 Crude drug properties
The bark of Phellodendron cork is in the form of flakes, and most of the cork has been removed, with a thickness of 1.5~4mm. The outer surface is greenish-yellow with irregular longitudinal ridges and grooves; the inner surface is grayish-yellow. The texture is tough, the broken surface is thorny and bright yellow, and the fiber layer can be peeled off in pieces. Slightly aromatic, extremely bitter and sticky. 12 Meridian distribution of nature and flavor
Cortex Cortex is bitter in taste and cold in nature; it enters the kidney, bladder, and large intestine meridians [2]. 13 Efficacy and Indications of Cortex Phellodendri
Cortex Phellodendri has the effects of clearing away heat and drying dampness, purging fire and removing steam, detoxifying and treating sores. It is used for damp-heat diarrhea, jaundice, leucorrhea, hot stranguria, athlete's foot, bone steam and labor fever. , night sweats, spermatorrhea, sores and swelling.
Cortex Phellodendron has the effects of purging fire, detoxifying, clearing away heat and drying dampness [2]:
Phellodendron Cortex cures damp-heat diarrhea, jaundice, stranguria, vaginal discharge, hemorrhoids, swelling and pain in the feet and knees, Damp-heat paralysis, yin deficiency and excessive fire, bone steaming and labor-heat, nocturnal emissions and vaginal discharge: decoct and take, 4.5-9g [2].
Eye drops of cork extract can be used to treat red, swollen and painful eyes [2].
Grind Cortex Phellodendri into powder and apply it to treat eczema, yellow water sores, aphtha, carbuncles, and burns [2].
The fruit of Cortex Phellodendron is called Huangboluoguo, which has the effect of relieving cough and eliminating phlegm [2].
Cortex Phellodendri is commonly used in ophthalmology as a heat-clearing and damp-drying medicine. It has the effects of clearing away heat and drying dampness, purging fire and detoxifying, and reducing deficiency heat:
(1) This product clears away heat and dampness, purges fire and detoxifies. Its effects are similar to those of Scutellaria baicalensis and Coptis chinensis. They are often used in conjunction with each other to treat various eye diseases caused by dampness, heat and fire poison.
(2) This product can clear away heat, and is used for internal and external eye diseases caused by insufficient kidney yin and excessive fire due to yin deficiency. It is often used in conjunction with Anemarrhenae, such as Zhibai Dihuang Pills. 14 Chemical composition of Cortex Phellodendri
Phellodendron Cortex mainly contains Berberis, and also contains palmatine, jatrorrhizine, phellodendrine, menisperine, and Baiqiao. Candicine, obacunone, etc.
The bark of the yellowbark tree contains biological agents such as barberry and phellodendron, as well as sterols, lactones, mucilage, etc. [2].
The bark of Phellodendron cypress contains biological agents such as Berberis berberii, Cortex Phellodendron, Medicinal Root Cortex, Palm Leaf Fanggena, and Pueraria lobata, as well as Obaculactone, β-sitosterol, etc. It also contains limonoids, corkone, milk tree alcohol, etc. [2].
Cortex Phellodendri can produce significant and lasting antihypertensive effects when injected intravenously or intraperitoneally into anesthetized animals [2].
Huangbaiquan has an inhibitory effect on the central nervous system [2].
Phellodendron lactone can reduce blood sugar in rabbits[2].
Cortex Phellodendron preparations have inhibitory effects on a variety of bacteria, pathogenic skin fungi, Leptospira and Trichomonas [2].
Bat Gerenquan has a curare-like muscle relaxant effect [2].
Barberry has mild choleretic, serum cholesterol lowering, and anti-inflammatory effects; it has also been reported to have antipyretic, antidiuretic, local anesthetic, sedative, analgesic, mild anticancer, and antiradiation properties. Function[2]. 15 Pharmacopoeia Standards for Phellodendron Cortex 15.1 Product Name
Phellodendron Cortex
Huangbo
PHELLODENDRI CHINENSIS CORTEX 15.2 Source
This product is Rutaceae plant Huangbo
The dry bark of the tree Phellodendron chinense Schneid. It is commonly known as "Sichuan Huangbai". After peeling the bark, remove the rough bark and dry it in the sun. 15.3 Properties
This product is in the shape of a plate or a shallow groove, with different lengths and widths, and a thickness of 1 to 6mm. The outer surface is yellow-brown or yellow-brown, flat or with longitudinal grooves, and sometimes lenticel marks and remaining gray-brown rough skin can be seen; the inner surface is dark yellow or light brown, with fine longitudinal ribs. The body is light, hard, the cross-section is fibrous, lobed and layered, dark yellow. The smell is slight, the taste is extremely bitter, and it is sticky when chewed. 15.4 Identification
(1) The powder of this product is bright yellow. The fibers are bright yellow, with a diameter of 16-38 μm, and are often bundled. The surrounding cells contain calcium oxalate square crystals, forming crystal fibers; the crystal-containing cell walls are woody and thickened. The stone cells are bright yellow, round or spindle-shaped, with a diameter of 35-128 μm. Some are branch-shaped, with sharp branch ends, thick walls, and obvious layering. Some large fibrous stone cells can be seen, up to 900 μm long. . There are many square crystals of calcium oxalate.
(2) Take 0.2g of this product powder, add 40ml of 1% acetic acid in methanol solution, ultrasonicate at 60°C for 20 minutes, filter, and concentrate the filtrate to 2ml as the test solution. Take another 0.1g of Phellodendron cork control medicinal material, add 1% acetic acid methanol 20ml, and prepare a reference medicinal material solution in the same way.
Then take Phellodendron hydrochloride reference substance and add methanol to make a solution containing 0.5mg per 1ml as the reference solution. According to the thin layer chromatography (Appendix VIB) test, draw 3 to 5 μl of each of the above three solutions, place them on the same silica gel G thin layer plate, and use the lower solution of chloroform, methanol and water (30:15:4) as the development agent, place it in a development cylinder saturated with ammonia vapor, unfold it, take it out, dry it, and spray it with dilute bismuth potassium iodide test solution. In the chromatogram of the test product, spots of the same color appear at the positions corresponding to the chromatogram of the control medicinal material and the reference substance. 15.5 Inspection 15.5.1 Moisture content
shall not exceed 12.0% (Appendix IXH Method 1). 15.5.2 Total ash content
shall not exceed 8.0% (Appendix IXK). 15.6 Leaching substance
Determine according to the cold soak method under the alcohol-soluble leachable determination method (Appendix X? A), using dilute ethanol as the solvent, not less than 14.0%. 15.7 Content determination 15.7.1 Berberis
Determination according to high performance liquid chromatography (Appendix VI B).
Chromatographic conditions and system suitability test? Use octadecylsilane bonded silica gel as filler; use acetonitrile 0.1% phosphoric acid solution (50:50) (add sodium dodecyl sulfonate per 100ml 0.1g) is the mobile phase; the detection wavelength is 265nm. The number of theoretical plates should not be less than 4000 based on the peak value of Berberis hydrochloride.
Preparation of reference substance solution? Take an appropriate amount of Berberis hydrochloride reference substance, weigh it accurately, add mobile phase to make a solution containing 0.1mg per 1ml, and you have it.
Preparation of test solution? Take about 0.1g of this product powder (passed through No. 3 sieve), weigh it accurately, put it in a 100ml measuring bottle, add 80ml of mobile phase, and ultrasonicate (power 250W, frequency 40kHz) for 40 minutes, let cool, dilute to volume with mobile phase, shake well, filter, and take the remaining filtrate to obtain.
Measurement method? Precisely draw 5 μl of the reference solution and 5 to 20 μl of the test solution, inject them into the liquid chromatograph, and measure.
Calculated as a dry product, this product contains berberine, calculated as berberine hydrochloride (C20H17NO4?HCl), which shall not be less than 3.0%. 15.7.2 Huangbaiquan
Determination according to high performance liquid chromatography (Appendix VD).
Chromatographic conditions and system suitability test? Use octadecylsilane bonded silica gel as filler; use acetonitrile 0.1% phosphoric acid solution (add 0.2g sodium dodecyl sulfonate per 100ml) (36 :64) is the mobile phase; the detection wavelength is 284nm. The number of theoretical plates should not be less than 6,000 based on the peak value of Huangbaihuo hydrochloride.
Preparation of reference substance solution? Take an appropriate amount of Phellodendron hydrochloride reference substance, weigh it accurately, add mobile phase to make a solution containing 0.1mg per 1m1, and you have it.
Preparation of test solution? Take about 0.5g of this product powder (passed through No. 4 sieve), weigh it accurately, place it in a stoppered conical flask, add 25ml of mobile phase accurately, weigh it, and ultrasonic Process (power 250W, frequency .40kHz) for 30 minutes, let cool, weigh again, use mobile phase to make up for the lost weight, shake well, filter, and take the filtrate to obtain.
Measurement method? Precisely draw 5μl each of the reference solution and the test solution, inject them into the liquid chromatograph, and measure.
Calculated as a dry product, this product contains Phellodendron, calculated as Phellodendron hydrochloride (C20H23NO4?HCl), which shall not be less than 0.34%. 15.8 Cortex Phellodendron decoction pieces 15.8.1 Processing 15.8.1.1 Phellodendron Cortex
Remove impurities, spray with water, moisten, cut into shreds and dry.
This product is in the shape of silk strips. The outer surface is yellowish brown or yellowish brown. The inner surface is dark yellow or light brown with longitudinal ribs. The cut surface is fibrous, lobed and layered, dark yellow. Very bitter taste. 15.8.1.1.1 Identification, inspection and content determination
Same as medicinal materials. 15.8.1.2 Salted Cortex Cortex
Take Cortex Cortex slivers and fry them dry according to the salt water method (Appendix IID).
This product is shaped like cypress silk, with a dark yellow surface and occasional burnt spots. The taste is extremely bitter and slightly bitter. 15.8.1.2.1 Identification, inspection and content determination
Same as medicinal materials. 15.8.1.3 Phellodendron charcoal
Take cork cypress and fry it according to the charcoal frying method (Appendix IID) until the surface is burnt black.
This product is shaped like cypress silk, with a burnt black surface and dark brown or brown-black interior. It is light, brittle and easy to break. Bitter taste. 15.8.2 Nature, flavor and meridians
Bitter, cold. Returns to the kidney and bladder meridians. 15.8.3 Functions and indications
Clear away heat and dry dampness, purge fire and remove steam, detoxify and treat sores. It is used for damp-heat diarrhea, jaundice and red urine, vaginal itching, hot stranguria and astringent pain, athlete's foot, fatigue and fever, night sweats, spermatorrhea, sores, swollen and poisonous sores, and eczema. Salt cork nourishes yin and reduces fire. Used for yin deficiency and excessive fire, night sweats and bone steaming. 15.8.4 Usage and dosage
3～12g.
Appropriate amount for external use. 15.8.5 Storage
Store in a ventilated and dry place, away from moisture.
15.9 Source
"The Pharmacopoeia of the People's Republic of China" 2010 Edition 16