With the development of feudal society, Huai 'an's former glory reached its peak in the prosperous period of Kanggan in Qing Dynasty. From a cultural point of view, Qiu Xiangsheng and Qiu Xiangsheng's brothers formed the Qiu literary family in Shunzhi and Kangxi periods of Qing Dynasty, and later Ruan literary family represented by Ruan Xuehao, Ruan Kuisheng and Ruan Zhisheng appeared.
During the Daoxian period of Qing Dynasty, Huai 'an experienced five hundred years of vicissitudes and five hundred years of cultural precipitation. In the cultural and academic circles, Pan Deyu, Lu Yitong, Ding Yan and Gao Yan, a fourth-generation scholar, appeared. In the same year, famous scholars and Duan appeared again. As a cultural phenomenon, after Wu Jutong, a large number of doctors emerged in Yang Shan Medical College, represented by Liu Jinfang. At the same time, painting, calligraphy and publishing have also made great progress.
Economic development promotes cultural development, and cultural development stimulates economic development. At this time, Huai 'an formed a large family of Ding, Wei, He and Si Xu with high political status, strong economic strength and profound cultural accomplishment.
During the light years of Qing Dynasty, the four most prosperous Huai 'an families declined rapidly and were replaced by Qin, Yang, Ye and Fan. Qin lives in the east of Xiaoyu market in the city, with the former Dazhaimen, and the Yang family is in the east of Genglou, represented by eight brothers, including Yang and Yang Shiqian. Ye's residence in Xingwen Street has been completely demolished, and Chuzhou Hotel has been built, while Fan's ancestral home is in Dingguang Bridge and later in Xichang Street. The original residence has also been destroyed, and Yuehu Community has been built.