Who should not eat rosuvastatin calcium tablets? What if I accidentally eat them?
The main component of rosuvastatin calcium tablets is rosuvastatin, and the pharmacological action of rosuvastatin calcium tablets is mainly through rosuvastatin. Rosuvastatin is a selective and competitive hmg-coa reductase inhibitor. Hmg-coa reductase is the rate-limiting enzyme in the process of transforming 3- hydroxy -3- formyl-CoA into cholesterol precursor mevalonate. Rosuvastatin has high uptake rate and selectivity in the liver, which is the target organ for lowering cholesterol. Moreover, rosuvastatin can increase the number of ldl receptors on the surface of liver cells, thus enhancing the uptake and catabolism of ldl and inhibiting the synthesis of vldl in liver, thus reducing the total number of vldl and ldl particles. So? Rosuvastatin is a selective and competitive hmg-coa reductase inhibitor. Therefore, the use of rosuvastatin calcium tablets in the treatment of primary hypercholesterolemia is generally prohibited for the following groups: 1. People who are allergic to rosuvastatin or any ingredient in rosuvastatin calcium tablets. 2. Patients with active liver disease, including patients whose serum transaminase continues to increase for unknown reasons, and the increase of serum transaminase exceeds the upper limit of normal value (ULN) by more than 3 times. 3. Patients with severe renal insufficiency (creatinine clearance rate