1. Give it to the bar girl "Korean celadon incense burner" (North 36 East 126), and she will open it for you when you enter the pub again;
2. When the African power value is 1000, St. George's Trade Association invites Hedram to crusade against the Mediterranean pirate Julius Fermir, and the guild will help you open it after the completion.
Destroying or coercing Espinosa (which is also ineffective and will die), the first time African forces enter Sofala, will lead to a plot. Angry people will execute Espy Nosha, and Serra will recognize him as the murderer of his people. After the story is over, Sheila can go to the kitchen. Sofala residents asked Hederam to find King Solomon's treasure, that is, the axe gun (North 64 West 15), and when it was finished, he could get the "lower part of the mysterious stone tablet" of Sofala.
Are you sure Sierra MM and Charlie/Manuel are in the main fleet?